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Abscisic acid signalling
Signalling of abscisic acid (ABA) in plants is characterized by an amazing number of secondary messengers that are part of the pathway or modulate...
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Oxidative stress signalling
Oxidative stress arises from an imbalance in the generation and removal of reactive oxygen species (ROS) within cells. ROS are produced during...
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Modelling signalling pathways – a yeast approach
MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as...
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Molecular genetics of genotoxic stress signalling in plants
Cells are under constant threat by endogenous and exogenous factors affecting DNA integrity. In response, complex signalling networks are activated...
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Signalling
Signalling is a non-biological paradigm for information processing. Biologists borrowed concepts from foreign disciplines, e.g. mechanical...
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Dysregulated Gab1 signalling in triple negative breast cancer
BackgroundBreast cancer is the most common cancer in women worldwide. Triple-negative breast cancer (TNBC) is especially aggressive and associated...
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Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and...
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Rapid Particle-Based Simulations of Cellular Signalling with the FLAME-Accelerated Signalling Tool (FaST) and GPUs
Cellular signalling is a vital process in living organisms for coordinating highly diverse responses to various stimuli. Particle-based modelling...
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Heavy metal signalling in plants: linking cellular and organismic responses
Heavy metals are required in plants as essential micronutrients or act as toxic compounds. How do plants perceive heavy metals and which signalling...
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Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages
TLR4 and TNFR1 signalling promotes potent proinflammatory signal transduction events, thus, are often hijacked by pathogenic microorganisms. We...
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Biological Signalling
This chapter is primarily concerned with signal transduction within cells: how information about a cell’s environment is transferred from the...
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Signalling cascades choreographing petal cell death: implications for postharvest quality
Senescence is a multifaceted and dynamic developmental phase pivotal in the plant's lifecycle, exerting significant influence and involving intricate...
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Context-dependent TGFβ family signalling in cell fate regulation
The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved cytokines whose signalling modulates cell fate...
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The Ecology of Reactive Oxygen Species Signalling
In the environment, plant growth is affected and controlled by various biotic and abiotic factors. The global climatic factors and abiotic stressors...
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Plant Responses to Hypoxia Stress: Signalling Cascades and Regulatory Mechanisms
Floods leading to waterlogged soil and submerged plants are one of the major abiotic stresses affecting plants across the globe. Extended time of...
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Redox regulation of UPR signalling and mitochondrial ER contact sites
Mitochondria and the endoplasmic reticulum (ER) have a synergistic relationship and are key regulatory hubs in maintaining cell homeostasis....
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Role of the NF-kB signalling pathway in heterotopic ossification: biological and therapeutic significance
Heterotopic ossification (HO) is a pathological process in which ectopic bone develops in soft tissues within the skeletal system. Endochondral...
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Metabolites as signalling molecules
Traditional views of cellular metabolism imply that it is passively adapted to meet the demands of the cell. It is becoming increasingly clear,...
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Lipid Metabolism, Compartmentalization and Signalling in the Regulation of Pollen Tube Growth
To understand the biological context of lipid metabolism and signalling in pollen, we have to consider male gametophytes as organisms optimised...
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N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling
Signalling through TNFR1 modulates proinflammatory gene transcription and programmed cell death, and its impairment causes autoimmune diseases and...
