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1. Editing and modification in trypanosomatids: the resha** of non-coding RNAs

   Trypanosomatids include a number of protozoan parasites that infect over 27 million people worldwide. Besides their medical importance, these...

   Mary Anne T. Rubio, Juan D. Alfonzo in Fine-Tuning of RNA Functions by Modification and Editing

   Chapter
   

2. Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs

   CRISPR-Cas systems and IS200/IS605 transposon-associated TnpBs have been utilized for the development of genome editing technologies. Using...

   Kuan Ren, Fengxia Zhou, ... Zhiwei Huang in Cell Research

   Article Open access 04 April 2024
   

3. Long non-coding RNAs: definitions, functions, challenges and recommendations

   Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term ‘lncRNAs’ encompasses RNA...

   John S. Mattick, Paulo P. Amaral, ... Mian Wu in Nature Reviews Molecular Cell Biology

   Article 03 January 2023
   

4. Targeted gene deletion with SpCas9 and multiple guide RNAs in Arabidopsis thaliana: four are better than two

   Background

   In plant genome editing, RNA-guided nucleases such as Cas9 from Streptococcus pyogenes ( Sp Cas9) predominantly induce small insertions or...

   Jana Ordon, Niklas Kiel, ... Johannes Stuttmann in Plant Methods

   Article Open access 28 March 2023
   

5. Tumor-derived exosomal non-coding RNAs as diagnostic biomarkers in cancer

   Almost all clinical oncologists agree that the discovery of reliable, accessible, and non-invasive biomarkers is necessary to decrease cancer...

   Nasim Ebrahimi, Ferdos Faghihkhorasani, ... Amir Reza Aref in Cellular and Molecular Life Sciences

   Article 29 October 2022
   

6. Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs

   Despite their fundamental role in assessing (patho)physiological cell states, conventional gene reporters can follow gene expression but leave scars...

   Dong-Jiunn Jeffery Truong, Niklas Armbrust, ... Gil Gregor Westmeyer in Nature Cell Biology

   Article Open access 07 November 2022
   

7. Structural insights into double-stranded RNA recognition and transport by SID-1

   RNA uptake by cells is critical for RNA-mediated gene interference (RNAi) and RNA-based therapeutics. In Caenorhabditis elegans , RNAi is systemic as...

   Jiangtao Zhang, Chunhua Zhan, ... Daohua Jiang in Nature Structural & Molecular Biology

   Article 25 April 2024
   

8. Spatial imaging of glycoRNA in single cells with ARPLA

   Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently discovered class of glycosylated molecules, because of a lack...

   Yuan Ma, Weijie Guo, ... Yi Lu in Nature Biotechnology

   Article 22 May 2023
   

9. Non-coding RNAs in the interaction between rice and Meloidogyne graminicola

   Background

   Root knot nematodes (RKN) are plant parasitic nematodes causing major yield losses of widely consumed food crops such as rice ( Oryza sativa ...

   Bruno Verstraeten, Mohammad Reza Atighi, ... Tina Kyndt in BMC Genomics

   Article Open access 20 July 2021
   

10. Cellular origins of dsRNA, their recognition and consequences

    Double-stranded RNA (dsRNA) is associated with most viral infections — it either constitutes the viral genome (in the case of dsRNA viruses) or is...

    Y. Grace Chen, Sun Hur in Nature Reviews Molecular Cell Biology

    Article 23 November 2021
    

11. Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo

    Current methods for programmed RNA editing using endogenous ADAR enzymes and engineered ADAR-recruiting RNAs (arRNAs) suffer from low efficiency and...

    Zongyi Yi, Liang Qu, ... Wensheng Wei in Nature Biotechnology

    Article 10 February 2022
    

12. Mechanisms and functions of RNA-guided RNA modification

    RNA-guided 2’-O-methylations and pseudouridylations occur in several different types of RNAs and in a wide range of organisms. Hundreds of the RNAs...

    Yi-Tao Yu, Rebecca M. Terns, Michael P. Terns in Fine-Tuning of RNA Functions by Modification and Editing

    Chapter
    

13. Genome-wide analysis of RNA-chromatin interactions in lizards as a mean for functional lncRNA identification

    Background

    Long non-coding RNAs (lncRNAs) are defined as transcribed molecules longer than 200 nucleotides with little to no protein-coding potential....

    Mariela Tenorio, Joanna Serwatowska, ... Diego Cortez in BMC Genomics

    Article Open access 07 August 2023
    

14. The Prospects of RNAs and Common Significant Pathways in Cancer Therapy and Regenerative Medicine

    Cells undergoing initiation of carcinogenesis and regeneration often share most of the molecular pathways. Consequently, cancer treatment may...

    Manaswini Gattupalli, Parry Dey, ... Satarupa Banerjee in Regenerative Medicine

    Chapter 2023
    

15. Comparative RNA Genomics

    Over the last quarter of a century it has become clear that RNA is much more than just a boring intermediate in protein expression. Ancient RNAs...

    Rolf Backofen, Jan Gorodkin, ... Peter F. Stadler in Comparative Genomics

    Protocol 2024
    

16. Purification of In Vivo or In Vitro-Assembled RNA-Protein Complexes by RNA Centric Methods

    Throughout their entire life cycle, RNAs are associated with RNA-binding proteins (RBPs), forming ribonucleoprotein (RNP) complexes with highly...

    Aurélie Janvier, Hassan Hayek, ... Gilbert Eriani in Advanced Technologies for Protein Complex Production and Characterization

    Chapter 2024
    

17. Structural basis of tRNA recognition by the m³C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase

    Methylation of cytosine 32 in the anticodon loop of tRNAs to 3-methylcytosine (m ³ C) is crucial for cellular translation fidelity. Misregulation of...

    Philipp Throll, Luciano G. Dolce, ... Eva Kowalinski in Nature Structural & Molecular Biology

    Article Open access 25 June 2024
    

18. Structural basis for RNA slicing by a plant Argonaute

    Argonaute (AGO) proteins use small RNAs to recognize transcripts targeted for silencing in plants and animals. Many AGOs cleave target RNAs using an...

    Yao **ao, Shintaro Maeda, ... Ian J. MacRae in Nature Structural & Molecular Biology

    Article 01 May 2023
    

19. Methyltransferase-directed orthogonal tagging and sequencing of miRNAs and bacterial small RNAs

    Background

    Targeted installation of designer chemical moieties on biopolymers provides an orthogonal means for their visualisation, manipulation and...

    Milda Mickutė, Kotryna Kvederavičiūtė, ... Giedrius Vilkaitis in BMC Biology

    Article Open access 22 June 2021
    

20. Particle bombardment technology and its applications in plants

    Particle bombardment, or biolistics, has emerged as an excellent alternative approach for plant genetic transformation which circumvents the...

    Ibrahim Ilker Ozyigit, Kuaybe Yucebilgili Kurtoglu in Molecular Biology Reports

    Article 21 November 2020