Search
Search Results
-
Effect of Unmetabolized Folic Acid on Immunoinflammatory Markers in Sickle Cell Disease Patients Taking Folic Acid Supplementation
Folic acid (FA) supplementation in sickle cell disease (SCD) patients lead to accumulation of unmetabolized folic acid (UMFA) which might influence...
-
Lipid and hemolysis parameters predicting acute chest syndrome in adulthood with sickle cell disease
Sickle cell disease (SCD) is a lifelong blood disorder affecting approximately 100,000 people in the United States and is one of the most common...
-
-
-
Anti-inflammatory cytokines in sickle cell disease
Sickle cell disease (SCD) is a well-studied monogenetic disease with an established chronic inflammatory component . The paradigm shift towards...
-
-
ATR1 Angiotensin II Receptor Reduces Hemoglobin S Polymerization, Phosphatidylserine Exposure, and Increases Deformability of Sickle Cell Disease Erythrocytes
Angiotensin II (Ang II) regulates blood volume and stimulates erythropoiesis through AT1 (ATR1) and AT2 (ATR2) receptors, found in multiple tissues,...
-
Atomic force microscopy reveals involvement of the cell envelope in biomechanical properties of sickle erythrocytes
BackgroundIntracellular hemoglobin polymerization has been supposed to be the major determinant for the elevated rigidity/stiffness of sickle...
-
Redefining the Reference Interval and Cut-Off Values of the Hematological and Biochemical Parameters and Deriving a Sensitive Predictive Marker for Crisis Events in Sickle Cell Disease
The heterogeneity in clinical presentations in sickle cell disease (SCD) alters between crisis and steady state phases. Considering the...
-
Metabolomic profiling for dyslipidemia in pediatric patients with sickle cell disease, on behalf of the IHCC consortium
BackgroundPrevious study has shown that dyslipidemia is common in patients with Sickle cell disease (SCD) and is associated with more serious SCD...
-
Hematologic Disease
Iron deficiency does not cause proliferative change or skull “porosityPorosity.” Marrow hyperplasiaHyperplasia is elicited by blood loss or...
-
Using DNA testing for the precise, definite, and low-cost diagnosis of sickle cell disease and other Haemoglobinopathies: findings from Tanzania
BackgroundSickle cell disease (SCD) is an important cause of under-five mortality. Tanzania is the 5th country in the world with the highest births...
-
Genetic modulation of anemia severity, hemolysis level, and hospitalization rate in Angolan children with Sickle Cell Anemia
BackgroundSickle Cell Anemia (SCA) is a genetic disease caused by the c.20 A > T mutation in HBB gene, generally characterized by sickle...
-
Polymorphisms and gene expression of metalloproteinases and their inhibitors associated with cerebral ischemic stroke in young patients with sickle cell anemia
BackgroundSickle cell anemia (SCA) is a genetic disease with great clinical heterogeneity and few viable strategies for treatment; hydroxyurea (HU)...
-
Evaluation of Paper-Based Point of Care Screening Test for Sickle Cell Disease
The aim of the study is to evaluate the stability and longevity of the paper-based screening test for the sickle cell disease in relation to...
-
Prediction of Hydroxyurea Effect on Sickle Cell Anemia Patients Using Machine Learning Method
The objective of this paper is to predict the effect of hydroxyurea of individuals suffering from Sickle Cell Disease (SCD) using predictive machine...
-
-
Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients
The aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events...