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GH2 family β-galactosidases evolution using degenerate oligonucleotide gene shuffling
ObjectivesTo improve the biochemical characteristics of the GH2 family β-galactosidases using a family shuffling method based on degenerate...
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Enhanced antimicrobial activity of lactic acid bacteria through genome shuffling and genetic variability among shuffled strains
In this investigation, lactic acid bacteria (LAB) isolated from milk were tested for their antibacterial properties and improved the antimicrobial...
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Shifting the pH profiles of Staphylococcus epidermidis lipase (SEL) and Staphylococcus hyicus lipase (SHL) through generating chimeric lipases by DNA shuffling strategy
Enzymes are often required to function in a particular reaction condition by the industrial procedure. In order to identify critical residues...
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Genome dosage alteration caused by chromosome pyramiding and shuffling effects on karyotypic heterogeneity, reproductive diversity, and phenotypic variation in Zea–Tripsacum allopolyploids
Key messageWe developed an array of Zea – Tripsacum tri-hybrid allopolyploids with multiple ploidies. We unveiled that changes in genome dosage due to...
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Dosage sensitivity and exon shuffling shape the landscape of polymorphic duplicates in Drosophila and humans
Despite polymorphic duplicate genes' importance for the early stages of duplicate gene evolution, they are less studied than old gene duplicates. Two...
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Analyzing the Function of Essential Genes by Plasmid Shuffling
Investigations on gene essentiality have important implications in several fields of basic and applied research. A variety of strategies have been...
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The role of background algal symbionts as drivers of shuffling to thermotolerant Symbiodiniaceae following bleaching in three Caribbean coral species
Reef-building corals host diverse dinoflagellate algal symbionts (Family Symbiodiniaceae) whose identity can influence host thermotolerance and whose...
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Bacterial bioreporters for the detection of trace explosives: performance enhancement by DNA shuffling and random mutagenesis
AbstractLandmines and other explosive remnants of war pose a global humanitarian problem that claims numerous casualties long after the conflict has...
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Applications and research advance of genome shuffling for industrial microbial strains improvement
Genome shuffling, an efficient and practical strain improvement technology via recursive protoplasts fusion, can break through the limits of species...
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Improvement of Acetic Acid Tolerance in Saccharomyces cerevisiae by Novel Genome Shuffling
AbstractThe aim of this study was to obtain new distilling strains of Saccharomyces cerevisiae with increased resistance to acetic acid, and, at the...
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Genomic Promoter Shuffling by Using Recyclable Cassettes
Genetic elements of interest can be introduced into the Saccharomyces cerevisiae genome via homologous recombination. A common method is to link such...
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Genome shuffling improves pigment and other bioactive compound production in Monascus purpureus
AbstractMonascus purpureus , a pigment-producing ascomycetous fungus, has been traditionally used for red rice preparation using solid-state...
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Improved AP-3 production through combined ARTP mutagenesis, fermentation optimization, and subsequent genome shuffling
Ansamitocin (AP-3) is an ansamycins antibiotic isolated from Actinosynnema pretiosum and demonstrating high anti-tumor activity. To improve AP-3...
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Study Essential Gene Functions by Plasmid Shuffling
An essential gene is defined as a gene that cannot be completely removed from the genome. Investigation of an essential gene function is limited...
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Combination of atmospheric and room temperature plasma (ARTP) mutagenesis, genome shuffling and dimethyl sulfoxide (DMSO) feeding to improve FK506 production in Streptomyces tsukubaensis
FK506 is a clinically important macrocyclic polyketide with immunosuppressive activity produced by Streptomyces tsukubaensis . However, the production...
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Enhanced poly-γ-l-diaminobutanoic acid production in Bacillus pumilus by combining genome shuffling with multiple antibiotic-resistance
A breeding approach combining genome shuffling with multiple antibiotic-resistance including gentamicin, rifampin and lincomycin, was developed in...
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Unraveling spatial cellular pattern by computational tissue shuffling
Cell biology relies largely on reproducible visual observations. Unlike cell culture, tissues are heterogeneous, making difficult the collection of...
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Genome shuffling based on different types of ribosome engineering mutants for enhanced production of 10-membered enediyne tiancimycin-A
Tiancimycin-A (TNM-A) is an anthraquinone-fused ten-membered enediyne produced by Streptomyces sp. CB03234, which is very promising for the...
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Genome Shuffling of Bacillus velezensis for Enhanced Surfactin Production and Variation Analysis
Surfactin is a promising microbial lipopeptide with wide applications in food, environmental, agricultural, and pharmaceutical fields. However, its...
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Genome shuffling for improving the activity of alkaline pectinase in Bacillus subtilis FS105 and its molecular mechanism
Genome shuffling for improving the activity of alkaline pectinase in Bacillus subtilis FS105 and its molecular mechanism were investigated. The fused...
