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  1. Short-chain fatty acids in diseases

    Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The...

    Dan Zhang, Yong-** Jian, ... Zhi-**ang Xu in Cell Communication and Signaling
    Article Open access 18 August 2023
  2. Short-chain fatty acids as a link between diet and cardiometabolic risk: a narrative review

    Aim

    Diet has a profound impact on cardiometabolic health outcomes such as obesity, blood glucose, blood lipids and blood pressure. In recent years,...

    Eline Birkeland, Sedegheh Gharagozlian, ... Anne-Marie Aas in Lipids in Health and Disease
    Article Open access 14 March 2023
  3. Changes of gut microbiota and short chain fatty acids in patients with Peutz–Jeghers syndrome

    Peutz–Jeghers Syndromeis a rare autosomal dominant genetic disease characterized by gastrointestinal hamartomatous polyps and skin and mucous...

    An Zhou, Bo Tang, ... Shiming Yang in BMC Microbiology
    Article Open access 30 November 2023
  4. Role of Tryptophan Metabolites and Short-Chain Fatty Acids in Pathogenesis of Autoimmune Diseases

    Abstract

    The prevalence of autoimmune diseases is steadily increasing worldwide. The etiology and pathogenesis of these diseases are extremely complex...

    O. P. Shatova, E. M. Yagodkina, ... A. V. Shestopalov in Journal of Evolutionary Biochemistry and Physiology
    Article 01 July 2023
  5. Short-chain fatty acids: possible regulators of insulin secretion

    The benefits of gut microbiota-derived short-chain fatty acids (SCFAs) towards health and metabolism have been emerging since the past decade....

    Nur Suraya Ashikin Rosli, Shafinaz Abd Gani, ... Mohd Badrin Hanizam Abdul Rahim in Molecular and Cellular Biochemistry
    Article 09 August 2022
  6. Predictable Representation of Metabolic Synthesis Pathways of Vitamins and Short-Chain Fatty Acids in Obese Adults

    Abstract

    Gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs) and vitamins, are involved in maintaining energy...

    A. V. Shestopalov, L. A. Ganenko, ... S. A. Roumiantsev in Journal of Evolutionary Biochemistry and Physiology
    Article 01 September 2023
  7. Short-chain fatty acids suppresses astrocyte activation by amplifying Trp-AhR-AQP4 signaling in experimental autoimmune encephalomyelitis mice

    The function of astrocytes in response to gut microbiota-derived signals has an important role in the pathophysiological processes of central nervous...

    **uli Lin, Yufeng Peng, ... **yi Xu in Cellular and Molecular Life Sciences
    Article Open access 08 July 2024
  8. Spinal cord injury-induced gut dysbiosis influences neurological recovery partly through short-chain fatty acids

    Spinal cord injury (SCI) can reshape gut microbial composition, significantly affecting clinical outcomes in SCI patients. However, mechanisms...

    Yingli **g, Degang Yang, ... Yan Yu in npj Biofilms and Microbiomes
    Article Open access 14 December 2023
  9. Regulatory role of short-chain fatty acids in inflammatory bowel disease

    Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders of the gastrointestinal tract. Accumulating evidence shows that...

    Zhilin Zhang, Huan Zhang, ... Dong Tang in Cell Communication and Signaling
    Article Open access 11 May 2022
  10. Supplementing the early diet of broilers with soy protein concentrate can improve intestinal development and enhance short-chain fatty acid-producing microbes and short-chain fatty acids, especially butyric acid

    Background

    Research on nutrition in early-life commonly focuses on the maturation of the intestine because the intestinal system is crucial for...

    Qianyun Zhang, Shan Zhang, ... Shourong Shi in Journal of Animal Science and Biotechnology
    Article Open access 08 September 2022
  11. Short-chain fatty acids (SCFAs) as potential resuscitation factors that promote the isolation and culture of uncultured bacteria in marine sediments

    Many marine bacteria are difficult to culture because they are dormant, rare or found in low-abundances. Enrichment culturing has been widely tested...

    Chun-Shui Sun, Liu-Yan Zhou, ... Da-Shuai Mu in Marine Life Science & Technology
    Article Open access 29 July 2023
  12. Role of folic acid in regulating gut microbiota and short-chain fatty acids based on an in vitro fermentation model

    Abstract  

    Folic acid deficiency is common worldwide and is linked to an imbalance in gut microbiota. However, based on model animals used to study the...

    **aogu Zheng, Chenlan **a, ... ** Li in Applied Microbiology and Biotechnology
    Article 04 January 2024
  13. Microbiota-derived short chain fatty acids in fermented Kidachi Aloe promote antimicrobial, anticancer, and immunomodulatory activities

    Background

    Fermented Aloe leaf juice is a commonly used food supplement in Japan. In a previous study, fermentation of A. arborescence juice was...

    Lamiaa A. Al-Madboly, Akira Yagi, ... Rasha M. El-Morsi in BMC Microbiology
    Article Open access 29 August 2023
  14. Growth performance, caecal microbiome profile, short-chain fatty acids, and litter characteristics in response to placement on reused litter and combined threonine, arginine and glutamine supplementation to juvenile male broiler chickens

    Background

    Exposure of broilers to litter microbiome may increase specific amino acid (AA) requirements towards activated immune responses. This may...

    Marwa A. Hussein, Farina Khattak, ... Jos G. M. Houdijk in Animal Microbiome
    Article Open access 22 March 2023
  15. The role of short-chain fatty acids in central nervous system diseases

    Previous studies have found that intracorporal short-chain fatty acids (SCFAs), as the main metabolites of the gut microbiota, play important roles...

    Yin Dong, Chun Cui in Molecular and Cellular Biochemistry
    Article 21 May 2022
  16. Liver sinusoidal endothelial cells rely on oxidative phosphorylation but avoid processing long-chain fatty acids in their mitochondria

    Background

    It is generally accepted that endothelial cells (ECs), primarily rely on glycolysis for ATP production, despite having functional...

    Patrycja Kaczara, Izabela Czyzynska-Cichon, ... Stefan Chlopicki in Cellular & Molecular Biology Letters
    Article Open access 09 May 2024
  17. Revealing the effect of sea buckthorn oil, fish oil and structured lipid on intestinal microbiota, colonic short chain fatty acid composition and serum lipid profiles in vivo

    In this study, the effects of sea buckthorn oil (SBO), fish oil (FO) and an enzymatically synthesized structured lipid (SL) on serum, short-chain...

    Ankang Song, Yanbo Li, ... Jikai Liu in Natural Products and Bioprospecting
    Article Open access 03 July 2024
  18. Impact of short chain fatty acids (SCFAs) on antimicrobial activity of new β-lactam/β-lactamase inhibitor combinations and on virulence of Escherichia coli isolates

    Abstract

    In a healthy gut microbiota, short chain fatty acids (SCFAs) are produced. The antibacterial action of SCFAs against intestinal pathogens...

    Ashraf A. Kadry, May A. El-Antrawy, Amira M. El-Ganiny in The Journal of Antibiotics
    Article Open access 01 February 2023
  19. Fatty Acids—‘Fueling Versus Steering’

    After a brief description of basic features of fatty acids (FAs), this chapter summarizes recent findings of FAs in terms of sensing, uptake, and...
    Christian E. W. Steinberg in Aquatic Animal Nutrition
    Chapter 2022
  20. Long-chain polyunsaturated fatty acids influence colorectal cancer progression via the interactions between the intestinal microflora and the macrophages

    The metabolism of long-chain polyunsaturated fatty acids (LCPUFAs) is closely associated with the risk and progression of colorectal cancer (CRC)....

    Duo Peng, Yan Wang, ... Yi Zhao in Molecular and Cellular Biochemistry
    Article 13 January 2024
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