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Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders
Studies suggest links between diabetes and gastrointestinal (GI) traits; however, their underlying biological mechanisms remain unclear. Here, we...
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Identifying patterns to uncover the importance of biological pathways on known drug repurposing scenarios
BackgroundDrug repurposing plays a significant role in providing effective treatments for certain diseases faster and more cost-effectively....
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Utilizing epigenetics to study the shared nature of development and biological aging across the lifespan
Recently, biological aging has been quantified in DNA-methylation samples of older adults and applied as so-called “methylation profile scores”...
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Diabetes risk loci-associated pathways are shared across metabolic tissues
Aims/hypothesisNumerous genome-wide association studies have been performed to understand the influence of genetic variation on type 2 diabetes...
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Unraveling the anti-breast cancer activity of Cimicifugae rhizoma using biological network pathways and molecular dynamics simulation
Cimicifugae is a commonly used treatment for breast cancer, but the specific molecular mechanisms underlying its effectiveness remain unclear. In...
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Identification of common genetic factors and immune-related pathways associating more than two autoimmune disorders: implications on risk, diagnosis, and treatment
Autoimmune disorders (ADs) are chronic conditions resulting from failure or breakdown of immunological tolerance, resulting in the host immune system...
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The influence of biological sex in human skeletal muscle transcriptome during ageing
Sex is a crucial biological variable, and influence of biological sex on the change of gene expression in ageing skeletal muscle has not yet been...
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Shared plasma metabolomic profiles of cognitive and mobility decline predict future dementia
Experiencing decline in both cognition and mobility is associated with a substantially higher dementia risk than cognitive decline only. Metabolites...
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Integrative Bioinformatics Approaches to Uncover Hub Genes and Pathways Involved in Cardiovascular Diseases
Cardiovascular diseases (CVD) represent a significant global health challenge resulting from a complex interplay of genetic, environmental, and...
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Exploring Lead loci shared between schizophrenia and Cardiometabolic traits
Individuals with schizophrenia (SCZ) have, on average, a 10- to 20-year shorter expected life span than the rest of the population, primarily due to...
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Robust single-cell matching and multimodal analysis using shared and distinct features
The ability to align individual cellular information from multiple experimental sources is fundamental for a systems-level understanding of...
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Ancient and recent origins of shared polymorphisms in yeast
Shared genetic polymorphisms between populations and species can be ascribed to ancestral variation or to more recent gene flow. Here, we mapped...
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Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma
Obesity and asthma are both common diseases with high population burden worldwide. Recent genetic association studies have shown that obesity is...
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Biological Networks
In several areas of biology, networks are frequently employed to conveniently describe interactions between relevant biological components....
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Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics
Depression, a highly prevalent disorder affecting over 280 million people worldwide, is comorbid with many neurological disorders, particularly...
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A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders
Consistent with the concept of the gut-brain phenomenon, observational studies suggest a relationship between Alzheimer’s disease (AD) and...
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Proteomic analysis of chromophobe renal cell carcinoma and benign renal oncocytoma biopsies reveals shared metabolic dysregulation
BackgroundThis study investigates the proteomic landscapes of chromophobe renal cell carcinoma (chRCC) and renal oncocytomas (RO), two subtypes of...
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Biological Networks Analysis
Networks are widely recognized as a popular method for representing complex biological processes by capturing the interconnected relationships...
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Genome-wide cross-trait analysis and Mendelian randomization reveal a shared genetic etiology and causality between COVID-19 and venous thromboembolism
Venous thromboembolism occurs in up to one-third of patients with COVID-19. Venous thromboembolism and COVID-19 may share a common genetic...
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Prediction of plant secondary metabolic pathways using deep transfer learning
BackgroundPlant secondary metabolites are highly valued for their applications in pharmaceuticals, nutrition, flavors, and aesthetics. It is of great...
