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Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Structural analysis of CFTR...
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Visual perceptual learning of feature conjunctions leverages non-linear mixed selectivity
Visual objects are often defined by multiple features. Therefore, learning novel objects entails learning feature conjunctions. Visual cortex is...
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Selectivity for food in human ventral visual cortex
Visual cortex contains regions of selectivity for domains of ecological importance. Food is an evolutionarily critical category whose visual...
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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation
The primary regulators of metazoan gene expression are enhancers, originally functionally defined as DNA sequences that can activate transcription at...
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Engineering Binders with Exceptional Selectivity
Molecular display technologies have enabled the generation of synthetic binders with high affinities against a variety of antigens. However,...
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Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors
Design of cannabinergic subtype selective ligands is challenging because of high sequence and structural similarities of cannabinoid receptors (CB 1 ...
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NanoBRETâ„¢ Live-Cell Kinase Selectivity Profiling Adapted for High-Throughput Screening
Kinases represent one of the most therapeutically tractable targets for drug discovery in the twenty-first century. However, confirming engagement...
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Heterogeneous selectivity and morphological evolution of marine clades during the Permian–Triassic mass extinction
Morphological disparity and taxonomic diversity are distinct measures of biodiversity, typically expected to evolve synergistically. However,...
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The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors
α5 subunit-containing γ-aminobutyric acid type A (GABA A ) receptors represent a promising drug target for neurological and neuropsychiatric disorders....
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Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2
Hydroxycarboxylic acid receptor 2 (HCAR2) belongs to the family of class A G protein-coupled receptors with key roles in regulating lipolysis and...
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Empirical verification of feeding selectivity of larval and juvenile pelagic fishes using in-situ zooplankton assemblages
Most studies on the feeding ecology of larvae and juveniles of commercially important pelagic fishes have used field-based approaches. However, due...
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Functions and substrate selectivity of diacylglycerol acyltransferases from Mortierella alpina
AbstractMortierella alpina produces various polyunsaturated fatty acids in the form of triacylglycerols (TAG). Diacylglycerol acyltransferase (DGAT)...
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Nutrient enrichment favors grazing selectivity and nutritional mismatch in a plankton community
Nitrogen (N) and phosphorus (P) limit the primary production of many aquatic ecosystems, and the cellular N:P ratio of phytoplankton is an important...
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Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters
Plant high-affinity K + transporters (HKTs) play a pivotal role in maintaining the balance of Na + and K + ions in plants, thereby influencing plant...
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Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors
Members of the melanocortin receptor (MCR) family that recognize different melanocortin peptides mediate a broad spectrum of cellular processes...
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Enhancer selectivity across cell types delineates three functionally distinct enhancer-promoter regulation patterns
BackgroundMultiple enhancers co-regulating the same gene is prevalent and plays a crucial role during development and disease. However, how multiple...
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Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter
The
T WIK-re lateds pinal cordK + channel (TRESK, K 2P 18.1) is a K 2P channel contributing to the maintenance of membrane potentials in various cells....
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Medicinal chemistry perspective of JAK inhibitors: synthesis, biological profile, selectivity, and structure activity relationship
JAK-STAT signalling pathway was discovered more than quarter century ago. The JAK-STAT pathway protein is considered as one of the crucial hubs for...
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Chloride homeostasis via enhanced salt ion secretion selectivity contributes to salt tolerance of recretohalophytic mangrove Avicennia marina
Background and AimsAvicennia marina , a pioneer recretohalophyte mangrove species living in intertidal wetlands, has high salinity tolerance. To...
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Structural insights into ligand recognition and selectivity of somatostatin receptors
Somatostatin receptors (SSTRs) play versatile roles in inhibiting the secretion of multiple hormones such as growth hormone and thyroid-stimulating...
