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Adipose-derived stem cells modified by TWIST1 silencing accelerates rat sciatic nerve repair and functional recovery
The regeneration of peripheral nerves after injury is often slow and impaired, which may be associated with weakened and denervated muscles...
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Skeletal Muscle Denervation: Sciatic and Tibial Nerve Transection Technique
The nerve transection model is an established and validated experimental model of skeletal muscle atrophy prepared by denervating the skeletal muscle...
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Transplantation of Neural Progenitor Cells Derived from Stem Cells from Apical Papilla Through Small-Molecule Induction in a Rat Model of Sciatic Nerve Injury
Background:Stem cell-based transplantation therapy holds promise for peripheral nerve injury treatment, but adult availability is limited. A cell...
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An Immunohistochemical Study of Rat Sciatic Nerve Macrophages after Injury and Subperineural Transplantation of Mesenchymal Stem Cells
AbstractThe dynamics of post-traumatic (ligation, 40 s) sciatic nerve Wallerian degeneration was studied in Wistar-Kyoto rats with the focus on the...
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Inverted human umbilical artery as a 3D scaffold for sciatic nerve regeneration in rats
Treatment of peripheral nerve injuries (PNIs) remains a challenge. Interposing a graft delivers better regenerative outcomes. Autografts present...
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scRNA-seq generates a molecular map of emerging cell subtypes after sciatic nerve injury in rats
Patients with peripheral nerve injury, viral infection or metabolic disorder often suffer neuropathic pain due to inadequate pharmacological options...
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Implantation of a nerve protector embedded with human GMSC-derived Schwann-like cells accelerates regeneration of crush-injured rat sciatic nerves
BackgroundPeripheral nerve injuries (PNIs) remain one of the great clinical challenges because of their considerable long-term disability potential....
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Chitosan Nerve Grafts Incorporated with SKP-SC-EVs Induce Peripheral Nerve Regeneration
BACKGROUND:Repair of long-distance peripheral nerve defects remains an important clinical problem. Nerve grafts incorporated with extracellular...
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3D-printed nerve guidance conduits multi-functionalized with canine multipotent mesenchymal stromal cells promote neuroregeneration after sciatic nerve injury in rats
BackgroundNerve injuries are debilitating, leading to long-term motor deficits. Remyelination and axonal growth are supported and enhanced by growth...
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A guide to reducing adverse outcomes in rabbit models of sciatic nerve injury
BackgroundPeripheral nerve damage can have debilitating consequences. Rabbit sciatic nerve transection models allow the effective evaluation of...
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Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain
BackgroundPeripheral nerve damage causes neuroinflammation, which plays a critical role in establishing and maintaining neuropathic pain (NeP). The...
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Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion
We develop soft and stretchable fatigue-resistant hydrogel optical fibers that enable optogenetic modulation of peripheral nerves in naturally...
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Effectiveness and Biocompatibility of Decellularized Nerve Graft Using an In Vivo Rat Sciatic Nerve Model
Background:Decellularized nerve allografting is one of promising treatment options for nerve defect. As an effort to develop more efficient nerve...
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Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models
BACKGROUND:Peripheral nerve damage mainly resulted from traumatic or infectious causes; the main signs of a damaged nerve are the loss of sensory...
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Harnessing three-dimensional porous chitosan microsphere embedded with adipose-derived stem cells to promote nerve regeneration
BackgroundNerve guide conduits are a promising strategy for reconstructing peripheral nerve defects. Improving the survival rate of seed cells in...
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Potential Application of Orofacial MSCs in Tissue Engineering Nerve Guidance for Peripheral Nerve Injury Repair
Injury to the peripheral nerve causes potential loss of sensory and motor functions, and peripheral nerve repair (PNR) remains a challenging...
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Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury
Transient receptor potential vanilloid 4 (TRPV4) is a non-selective calcium-permeable cation channel that is widely expressed and activated in...
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Therapeutic effects of peripherally administrated neural crest stem cells on pain and spinal cord changes after sciatic nerve transection
BackgroundSevere peripheral nerve injury significantly affects patients’ quality of life and induces neuropathic pain. Neural crest stem cells...
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Taurine ameliorates axonal damage in sciatic nerve of diabetic rats and high glucose exposed DRG neuron by PI3K/Akt/mTOR-dependent pathway
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes and axonopathy is its main pathological feature. Previous studies suggested...
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Artificial Nerve Containing Stem Cells, Vascularity and Scaffold; Review of Our Studies
To promote nerve regeneration within a conduit (tubulation), we have performed studies using a tube model based on four important concepts for tissue...
