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Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy
Conventional angiogenic factors, such as vascular endothelial growth factor (VEGF), regulate both pathological and physiological angiogenesis...
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Neurovascular regulation in diabetic retinopathy and emerging therapies
Diabetic retinopathy (DR) is the leading cause of vision loss in working adults in developed countries. The disease traditionally classified as a...
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Sustainable Tilapia Farming, the Role of Culture Systems
Considering environmental sustainability and vulnerability to the effects of climate change on fish production, sustainable and adaptable aquaculture...
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Unveiling adcyap1 as a protective factor linking pain and nerve regeneration through single-cell RNA sequencing of rat dorsal root ganglion neurons
BackgroundSevere peripheral nerve injury (PNI) often leads to significant movement disorders and intractable pain. Therefore, promoting nerve...
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Comprehensive scRNA-seq Model Reveals Artery Endothelial Cell Heterogeneity and Metabolic Preference in Human Vascular Disease
Vascular disease is one of the major causes of death worldwide. Endothelial cells are important components of the vascular structure. A better...
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Single-cell RNA sequencing technology in human spermatogenesis: Progresses and perspectives
Spermatogenesis, a key part of the spermiation process, is regulated by a combination of key cells, such as primordial germ cells, spermatogonial...
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The relationship between regulatory changes in cis and trans and the evolution of gene expression in humans and chimpanzees
BackgroundComparative gene expression studies in apes are fundamentally limited by the challenges associated with sampling across different tissues....
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Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders
BackgroundCardio-metabolic disorders (CMDs) are common in aging people and are pivotal risk factors for cardiovascular diseases (CVDs). Inflammation...
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Paracrine Factors Released by Stem Cells of Mesenchymal Origin and their Effects in Cardiovascular Disease: A Systematic Review of Pre-clinical Studies
Mesenchymal stem cell (MSC) therapy has gained significant traction in the context of cardiovascular repair, and have been proposed to exert their...
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Genome-wide association study for stayability at different calvings in Nellore beef cattle
BackgroundingStayability, which may be defined as the probability of a cow remaining in the herd until a reference age or at a specific number of...
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Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing of frog lung
The evolution and development of vertebrate lungs have been widely studied due to their significance in terrestrial adaptation. Amphibians possess...
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Aqueous humor proteomics analyzed by bioinformatics and machine learning in PDR cases versus controls
BackgroundTo comprehend the complexities of pathophysiological mechanisms and molecular events that contribute to proliferative diabetic retinopathy...
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Relationships of tumor differentiation and immune infiltration in gastric cancers revealed by single-cell RNA-seq analyses
Gastric cancers are highly heterogeneous malignant tumors. To reveal the relationship between differentiation status of cancer cells and tumor immune...
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Sprouty genes regulate activated fibroblasts in mammary epithelial development and breast cancer
Stromal fibroblasts are a major stem cell niche component essential for organ formation and cancer development. Fibroblast heterogeneity, as revealed...
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A comprehensive systematic review of CSF proteins and peptides that define Alzheimer’s disease
BackgroundDuring the last two decades, over 100 proteomics studies have identified a variety of potential biomarkers in CSF of Alzheimer’s (AD)...
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DNA methylation age analysis of rapamycin in common marmosets
Human DNA methylation data have previously been used to develop highly accurate biomarkers of aging (“epigenetic clocks”). Subsequent studies...
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Strategies for arterial graft optimization at the single-cell level
Common arterial grafts used in coronary artery bypass grafting include internal thoracic artery (ITA), radial artery (RA) and right gastroepiploic...
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Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development
Molecular clocks operate in peripheral tissues, including endocrine glands, and play important regulatory roles in this context. However, potential...
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Strain-based and sex-biased differences in adrenal and pancreatic gene expression between KK/HlJ and C57BL/6 J mice
BackgroundThe ever-increasing prevalence of diabetes and associated comorbidities serves to highlight the necessity of biologically relevant...
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Prediction of Ubiquitin Ligase Nrdp1-Associated Proteins in Glioma Database
The ubiquitin proteasome pathway is conserved from yeast to mammals and is necessary for the targeted degradation of most short-lived proteins in...
