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Brucine Suppresses Malignant Progression of Prostate Cancer by Decreasing Sarcosine Accumulation via Downregulation of GNMT in the Glycine/sarcosine Metabolic Pathway
Prostate cancer (PCa) remains a leading cause of cancer-related incidence and mortality in men. Disruptions in amino acid (AA) metabolism contribute...
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An efficient one-pot synthesis and docking studies of bioactive new antiproliferative dispiro[oxindole/acenaphthylenone‒benzofuranone] pyrrolidine scaffolds
A new and efficient method has been developed to synthesize dispiro[oxindole/acenaphthylenone-benzofuranone]pyrrolidine compounds. This is done by...
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Untargeted metabolomics analysis of plasma metabolic characteristics in patients with acne and insulin resistance
Acne vulgaris is a chronic inflammatory disease with high incidence, diverse clinical manifestations, poor clinical efficacy, and easy recurrence....
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Isolation and optimization of a glyphosate-degrading Rhodococcus soli G41 for bioremediation
A widely used herbicide for controlling weeds, glyphosate, is causing environmental pollution. It is necessary to remove it from environment using a...
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Targeted metabolomic analysis of serum amino acids in heart failure patients
Heart failure (HF) has been recognized as a global epidemic with high rates of morbidity, hospitalization, and mortality. The role of amino acids,...
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Association of amino acid metabolites with osteoporosis, a metabolomic approach: Bushehr elderly health program
Introduction and objectivesAmino acids are the most frequently reported metabolites associated with low bone mineral density (BMD) in metabolomics...
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Assessment of Malaysian brown seaweed Padina gymnospora antioxidant properties and antimicrobial activity in different solvent extractions
The combination of a proton nuclear magnetic resonance ( 1 H-NMR)-based metabolomics approach and principal component analysis (PCA) was used to...
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Metataxonomic and metabolomic profiling revealed Pinus koraiensis cone essential oil reduced methane emission through affecting ruminal microbial interactions and host-microbial metabolism
BackgroundPinus koraiensis cone essential oil (PEO) contains functional compounds such as monoterpene hydrocarbons, and the administration of PEO...
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Intermittent fasting protects against Alzheimer’s disease in mice by altering metabolism through remodeling of the gut microbiota
Alzheimer’s disease (AD) is the most common form of dementia without effective clinical treatment. Here, we show that intermittent fasting (IF)...
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Changes of extracted bioactive compounds from brown algae (Cystoseira indica) after conversion to mill and tablet using a quantitative metabolomics approach
There is develo** importance in the biomedical use of seaweeds such as brown algae, mostly due to their contents of bioactive substances. In the...
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Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading
During duration spaceflight, or after their return to earth, astronauts have often suffered from gait instability and cerebellar ataxia. Here, we use...
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Microbial Utilization of Glycine Betain in Hypersaline Soda Lakes
AbstractGlycine betaine (GB) is a biologically important compound for microbial communities living in saline habitats most commonly employed as an...
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Chiral resolution of N-methyl-d,l-aspartic acid using a predicted N-demethylase from Chloroflexi bacterium 54-19
N -methyl- d -aspartic acid (NMDA), an amino acid existing in human and animal central nervous system, exerts agonist action on one of the glutamate...
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A Green one-pot three component synthesis of thiazolidine-2,4-dione based bisspirooxindolo-pyrrolidines with [Bmim]BF4: their in vitro and in silico anti-TB studies
A simple and effective three-component one-pot green methodology was employed for the synthesis of a new thiazolidine-2,4-dione based...
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SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice
Non-alcoholic fatty liver disease is associated with an irregular serine metabolism. Serine hydroxymethyltransferase 2 (SHMT2) is a liver enzyme that...
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Impact of glyphosate and glyphosate-based herbicides on phyllospheric Methylobacterium
Symbiotic Methylobacterium comprise a significant portion of the phyllospheric microbiome, and are known to benefit host plant growth, development,...
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A facile synthesis of chromeno[3,4-c]spiropyrrolidine indenoquinoxalines via 1,3-dipolar cycloadditions
A one-pot, four-component reaction for the synthesis of novel chromeno[3,4- c ]spiropyrrolidine-indenoquinoxalines is described via a 1,3-dipolar...
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Effects of hyposalinity on ion content, organic osmolytes, and lipid peroxidation in the seagrass Halodule wrightii
Critical seagrass ecosystems are predicted to be impacted by droughts and floods of increasing severity and frequency as the climate changes....
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Metabolites, gene expression, and gut microbiota profiles suggest the putative mechanisms via which dietary creatine increases the serum taurine and g-ABA contents in Megalobrama amblycephala
A 90-day experiment was conducted to explore the effects of creatine on growth performance, liver health status, metabolites, and gut microbiota in Meg...
