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Association between SUMF1 polymorphisms and COVID-19 severity
BackgroundEvidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor...
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Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease
Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors, is an established...
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Unique adaptations in neonatal hepatic transcriptome, nutrient signaling, and one-carbon metabolism in response to feeding ethyl cellulose rumen-protected methionine during late-gestation in Holstein cows
BackgroundMethionine (Met) supply during late-pregnancy enhances fetal development in utero and leads to greater rates of growth during the neonatal...
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A comprehensive genome-wide scan detects genomic regions related to local adaptation and climate resilience in Mediterranean domestic sheep
BackgroundThe management of farm animal genetic resources and the adaptation of animals to climate change will probably have major effects on the...
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Single-step genome-wide association analyses of claw horn lesions in Holstein cattle using linear and threshold models
BackgroundLameness in dairy cattle is primarily caused by foot lesions including the claw horn lesions (CHL) of sole haemorrhage (SH), sole ulcers...
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The potential roles of amino acids and their major derivatives in the management of multiple sclerosis
Recently, we reviewed the important role of carbohydrates and lipids metabolism in different clinical aspects of multiple sclerosis (MS) disease. In...
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Juvenil- und Steroid-Hormone
Ausgehend von der Mevalonsäure wird in Vertebraten und Invertebraten aus Isoprenyloligomeren, Squalen und Cholesterin eine Vielzahl von Hormonen...
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Comparative analysis of the ovarian transcriptome reveals novel insights into fertility differences in Large White sows
BackgroundFertility is the most important economic trait in sows, as it is critical for profitability. Considerable phenotypic variation in litter...
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Significant improvement of miRNA target prediction accuracy in large datasets using meta-strategy based on comprehensive voting and artificial neural networks
BackgroundIdentifying mRNA targets of miRNAs is critical for studying gene expression regulation at the whole-genome level. Multiple computational...
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The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure
BackgroundAllele-specific DNA methylation (ASM) describes genomic loci that maintain CpG methylation at only one inherited allele rather than having...
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Novel mutations in the GJC2 gene associated with Pelizaeus–Merzbacher-like disease
Inherited white matter disorders of the central nervous system frequently are degenerative and progressive clinical entities. They are classified...
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Rab20 is critical for bacterial lipoprotein tolerization-enhanced bactericidal activity in macrophages during bacterial infection
Bacterial cell wall component-induced tolerance represents an important protective mechanism during microbial infection. Tolerance induced by the...
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Lysosomes as dynamic regulators of cell and organismal homeostasis
Exciting new discoveries have transformed the view of the lysosome from a static organelle dedicated to the disposal and recycling of cellular waste...
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Heparan sulfate proteoglycans as key regulators of the mesenchymal niche of hematopoietic stem cells
The complex microenvironment that surrounds hematopoietic stem cells (HSCs) in the bone marrow niche involves different coordinated signaling...
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Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria
Sulfatases that specifically catalyze the hydrolysis of the sulfate groups on chondroitin sulfate (CS)/dermatan sulfate (DS) poly- and...
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VaProS: a database-integration approach for protein/genome information retrieval
Life science research now heavily relies on all sorts of databases for genome sequences, transcription, protein three-dimensional (3D) structures,...
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Identification of microRNA and target gene associated with marbling score in Korean cattle (Hanwoo)
Marbling is a crucial characteristic in meat quality assessment. In the search for a genetic basis of meat quality, a large number of gene analyses...
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Evidence of selection signatures that shape the Persian cat breed
The Persian cat is mainly characterized by an extremely brachycephalic face as part of the standard body conformation. Despite the popularity,...
