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The STK38–XPO1 axis, a new actor in physiology and cancer
The Hippo signal transduction pathway is an essential regulator of organ size during developmental growth by controlling multiple cellular processes...
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Functional analysis of a common BAG3 allele associated with protection from heart failure
Multiple genetic association studies have correlated a common allelic block linked to the BAG3 gene with a decreased incidence of heart failure, but...
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RBM24 controls cardiac QT interval through CaMKIIδ splicing
Calcium/calmodulin-dependent kinase II delta ( CaMKIIδ ) is the predominant cardiac isoform and it is alternatively spliced to generate multiple...
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Emerging role of the Hippo pathway in autophagy
Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and...
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TMT quantitative proteomics reveals key proteins relevant to microRNA-1-mediated regulation in osteoarthritis
Osteoarthritis (OA) is the second-commonest arthritis, but pathogenic and regulatory mechanisms underlying OA remain incompletely understood. Here,...
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Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability
BackgroundGenome-wide association studies have reported more than 100 risk loci for rheumatoid arthritis (RA). These loci are shown to be enriched in...
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NanoBRET™ Live-Cell Kinase Selectivity Profiling Adapted for High-Throughput Screening
Kinases represent one of the most therapeutically tractable targets for drug discovery in the twenty-first century. However, confirming engagement...
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Quantitative proteomics analysis in small cell carcinoma of cervix reveals novel therapeutic targets
BackgroundAs a rare pathologic subtype, small cell carcinoma of the cervix (SCCC) is characterized by extensive aggressiveness and resistance to...
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Epigenetic Reprogramming of the Glucose Metabolic Pathways by the Chromatin Effectors During Cancer
Glucose metabolism plays a vital role in regulating cellular homeostasis as it acts as the central axis for energy metabolism, alteration in which...
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The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1
Heavy metals are both integral parts of cells and environmental toxicants, and their deregulation is associated with severe cellular dysfunction and...
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Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma
BackgroundGenetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such aberrations remain poorly...
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MST1/2 Kinase Assays Using Recombinant Proteins
The Hippo tumor suppressor pathway is fundamental to the coordination of death, growth, proliferation, and differentiation on the cellular level. At...
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Measuring the Kinase Activities of the LATS/NDR Protein Kinases
The Hippo tissue growth control and regeneration pathway is a main regulator of the YAP/TAZ effectors. In this regard, the LATS/NDR serine/threonine...
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MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis
T cell-mediated immunity in the intestine is stringently controlled to ensure proper immunity against pathogenic microbes and to prevent...
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PAR3–PAR6–atypical PKC polarity complex proteins in neuronal polarization
Polarity is a fundamental feature of cells. Protein complexes, including the PAR3–PAR6–aPKC complex, have conserved roles in establishing polarity...
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Genetic interaction map** and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
Systematic map** of genetic interactions (GIs) and interrogation of the functions of sizable genomic segments in mammalian cells represent...
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MICOP: Maximal information coefficient-based oscillation prediction to detect biological rhythms in proteomics data
BackgroundCircadian rhythms comprise oscillating molecular interactions, the disruption of the homeostasis of which would cause various disorders. To...
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Salivary miR-16, miR-191 and miR-223: intuitive indicators of dominant ovarian follicles in buffaloes
Estrus or sexual receptivity determination is utmost important for efficient breeding programs for female buffaloes. Prominent estrus behavioral...
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Tumor suppressor C-RASSF proteins
Human genome has ten genes that are collectedly called Ras association domain family ( RASSF ). RASSF is composed of two subclasses, C - RASSF and N - RASSF ...
