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PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells
An increasing number of studies have documented atypical protein kinase C isoform ι (PKCι) as an oncoprotein playing multifaceted roles in pancreatic...
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STAT3 mediates ECM stiffness-dependent progression in ovarian cancer
The treatment of ovarian cancer remains a medical challenge and its malignant progression is connected with obvious changes in both tissue and cell...
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The regulatory relationship between transcription factor STAT3 and noncoding RNA
Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor...
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PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer
Overcoming distant metastasis stands as a paramount challenge in enhancing the outcomes of breast cancer treatments. Thus, delving deeper into...
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STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia
STAT3 and HIF1α are two fundamental transcription factors involved in many merging processes, like angiogenesis, metabolism, and cell...
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STAT3 and SOX-5 induce BRG1-mediated chromatin remodeling of RORCE2 in Th17 cells
Retinoid-related orphan receptor gamma t (RORγt) is the lineage-specific transcription factor for T helper 17 (Th17) cells. Our previous study...
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**huang pill facilitates glioma cell pyroptosis via the POU4F1/STAT3 axis
Glioma is the most common malignancy in the central nervous system. This study aims to disclose the impacts of **huang pill (XHP), a traditional...
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METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway
The role of METTL3-mediated N6-methyladenosine (m 6 A) modification has been elucidated in several cancers, but the concrete mechanism underlying its...
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PRMT5-mediated methylation of STAT3 is required for lung cancer stem cell maintenance and tumour growth
STAT3 is constitutively activated in many cancer types, including lung cancer, and can induce cancer cell proliferation and cancer stem cell (CSC)...
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Selective activation of STAT3 and STAT5 dictates the fate of myeloid progenitor cells
The molecular programs that govern the directed differentiation of myeloid progenitor cells are still poorly defined. Using a previously established...
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ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity
Wnt pathway dysregulation through genetic and non-genetic alterations occurs in multiple cancers, including ovarian cancer (OC). The aberrant...
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NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma
BackgroundMelanoma is a highly heterogeneous cancer, in which frequent changes in activation of signaling pathways lead to a high adaptability to...
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PCSK5 downregulation promotes the inhibitory effect of andrographolide on glioblastoma through regulating STAT3
Proprotein convertase subtilisin/kexin type 5 (PCSK5) is a member of the proprotein convertase (PC) family, which processes immature proteins into...
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TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness
IntroductionWe previously reported that TRPM7 regulates glioma cells’ stemness through STAT3. In addition, we demonstrated that FOSL1 is a response...
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IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1
Matrix metalloproteinase-1 (MMP1) has an aberrant expression relevant to various behaviors of cancers. As dominant components of the tumor stroma,...
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Deciphering STAT3 signaling potential in hepatocellular carcinoma: tumorigenesis, treatment resistance, and pharmacological significance
Hepatocellular carcinoma (HCC) is considered one of the greatest challenges to human life and is the most common form of liver cancer. Treatment of...
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RPL22L1, a novel candidate oncogene promotes temozolomide resistance by activating STAT3 in glioblastoma
Aggressiveness and drug resistance are major challenges in the clinical treatment of glioblastoma (GBM). Our previously research reported a novel...
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Hypoxia Potentiated Lung Cancer Cell Migration and Invasion by up-regulating HIF1α/JAK2/STAT3 Axis and Activating MMP13 Transcription
Excessive aggressive migration and invasion are important factors that increase the mortality of cancer patients. Matrix metalloproteinase 13 (MMP13)...
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miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway
Hematopoiesis ensures tissue oxygenation, and remodeling as well as immune protection in vertebrates. During embryogenesis, hemangioblasts are the...
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S100A8/A9 promotes endometrial fibrosis via regulating RAGE/JAK2/STAT3 signaling pathway
Intrauterine adhesion (IUA) is characterized by endometrial fibrosis. S100A8/A9 plays an important role in inflammation and fibroblast activation....
