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1. Epigenetic Changes in Aging: The Contribution of SIRT1 to Longevity

   Aging encompasses the gradual and intrinsic progression of physical, psychological, and functional changes that occur in living organisms over time....

   Débora Kristina Alves-Fernandes, Miriam Galvonas Jasiulionis in Cellular and Molecular Aspects of Ageing

   Chapter 2024
   

2. SIRT1 regulates hepatic vldlr levels

   Background

   Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR)...

   Mona Peyman, Anna Babin-Ebell, ... Manuel Vázquez-Carrera in Cell Communication and Signaling

   Article Open access 28 May 2024
   

3. The role and regulation of SIRT1 in pulmonary fibrosis

   Pulmonary fibrosis (PF) is a progressive and fatal lung disease with high incidence and a lack of effective treatment, which is a severe public...

   **nyi Ma, Mengna Jiang, ... **nyuan Zhao in Molecular Biology Reports

   Article 23 February 2024
   

4. SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1

   The silent information regulator T1 (SIRT1) is linked to longevity and is a crucial mediator of osteoblast function. We investigated the direct role...

   **nxin **, Xulei Sun, ... Hongzhi Sun in Cellular and Molecular Life Sciences

   Article 03 May 2024
   

5. SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury

   Mitochondrial dysfunction contributes to cerebral ischemia–reperfusion (CI/R) injury, which can be ameliorated by Sirtuin-3 (SIRT3). Under stress...

   Manli Chen, Ji Liu, ... Hongbin Chen in Cell Biology and Toxicology

   Article Open access 20 May 2024
   

6. SIRT1 regulates hepatocyte programmed cell death via GSDME - IL18 axis in human and mouse liver transplantation

   Sirtuin 1 (SIRT1) is a histone/protein deacetylase in the cellular response to inflammatory, metabolic, and oxidative stressors. We previously...

   Kentaro Kadono, Hidenobu Kojima, ... Jerzy W. Kupiec-Weglinski in Cell Death & Disease

   Article Open access 23 November 2023
   

7. SIRT1 and HSP90α feed-forward circuit safeguards chromosome segregation integrity in diffuse large B cell lymphomas

   Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma in adults, exhibiting highly heterogenous clinical behavior...

   Emilia Białopiotrowicz-Data, Monika Noyszewska-Kania, ... Przemysław Juszczyński in Cell Death & Disease

   Article Open access 11 October 2023
   

8. Andrographis modulates cisplatin resistance in lung cancer via miR-155-5p/SIRT1 axis

   Andrographis (Andro) has been identified as an anti-cancer herbal. This study was to explore its underlying regulatory routes regarding cisplatin...

   Chong Pang, Tengyue Zhang, ... Changli Wang in Functional & Integrative Genomics

   Article 02 August 2023
   

9. SIRT1 safeguards adipogenic differentiation by orchestrating anti-oxidative responses and suppressing cellular senescence

   Adipose tissue is an important endocrine organ that regulates metabolism, immune response and aging in mammals. Healthy adipocytes promote tissue...

   An Yu, Ruofan Yu, ... Weiwei Dang in GeroScience

   Article 08 July 2023
   

10. SIRT1 activation attenuates palmitate induced apoptosis in C₂C₁₂ muscle cells

    Background

    Type 2 diabetes is characterized by insulin resistance, which manifests mainly in skeletal muscles. SIRT1 has been found to play a role in...

    Gholamreza Taheripak, Niusha Sabeti, ... Iraj Alipourfard in Molecular Biology Reports

    Article 24 February 2024
    

11. Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy

    Mounting studies have substantiated that abrogating autophagy contributes to cardiac hypertrophy (CH). Sirtuin 1 (SIRT1) has been reported to support...

    Weichen Wang, Longlong Wang, ... Yuze Li in Cell Death & Disease

    Article Open access 10 November 2021
    

12. Cellular metabolic pathways of aging in dogs: could p53 and SIRT1 be at play?

    Aging and cancer seem to be closely associated, such that cancer is generally considered a disease of the elderly in both humans and dogs....

    Ana Gabriela Jiménez, Kailey D. Paul, ... William Cipolli in GeroScience

    Article 28 September 2023
    

13. Role of sirtuin 1 (SIRT1) in regulation of autophagy and nuclear factor-kappa Beta (NF-ĸβ) pathways in sorafenib-resistant hepatocellular carcinoma (HCC)

    Hepatocellular carcinoma (HCC) remains a major global health problem with high incidence and mortality. Diagnosis of HCC at late stages and tumour...

    Hui-Yin Chan, Thamil Selvee Ramasamy, ... Sin-Yeang Teow in Cell Biochemistry and Biophysics

    Article 11 March 2024
    

14. Liraglutide prevents cellular senescence in human retinal endothelial cells (HRECs) mediated by SIRT1: an implication in diabetes retinopathy

    Diabetes mellitus (DM) is a chronic metabolic disorder affecting millions of people worldwide, characterized by dysregulated glucose homeostasis and...

    Lihua Hou, Jianying Du, ... Jifei Zhao in Human Cell

    Article Open access 04 March 2024
    

15. SIRT1 and ZNF350 as novel biomarkers for osteoporosis: a bioinformatics analysis and experimental validation

    Background

    Osteoporosis (OP) is characterized by bone mass decrease and bone tissue microarchitectural deterioration in bone tissue. This study...

    Naiqiang Zhu, **gyi Hou, ... Liguo Zhu in Molecular Biology Reports

    Article 18 April 2024
    

16. Genetic variation in bovine LAP3 and SIRT1 genes associated with fertility traits in dairy cattle

    Background

    The genetic progress of fertility and reproduction traits in dairy cattle has been constrained by the low heritability of these traits....

    Destaw Worku, Archana Verma in BMC Genomic Data

    Article Open access 18 March 2024
    

17. Involvement of the SIRT1-NLRP3 pathway in the inflammatory response

    The silent information regulator 2 homolog 1-NACHT, LRR and PYD domains-containing protein 3 (SIRT1-NLRP3) pathway has a crucial role in regulation...

    Huiyue Chen, Jiayu Deng, ... **ghui Zhai in Cell Communication and Signaling

    Article Open access 28 July 2023
    

18. Role of SIRT1 in Potentially Toxic Trace Elements (Lead, Fluoride, Aluminum and Cadmium) Associated Neurodevelopmental Toxicity

    The formation of the central nervous system is a meticulously planned and intricate process. Any modification to this process has the potential to...

    Aqsa Fathima, Newly Bagang, ... Smita Shenoy in Biological Trace Element Research

    Article Open access 28 February 2024
    

19. SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway

    SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, is downregulated in oral...

    Srimanta Patra, Amruta Singh, ... Sujit K. Bhutia in Cell Death & Disease

    Article Open access 10 November 2023
    

20. Protective effect of melatonin against methamphetamine-induced attention deficits through miR-181/SIRT1 axis in the prefrontal cortex

    Introduction

    Methamphetamine (METH) is an addictive psychostimulant with deleterious effects on the central nervous system. Chronic use of METH in...

    Seyed Khalil Rashidi, Mitra Ansari Dezfouli, ... Ali Akbar Shabani in Molecular Biology Reports

    Article 25 May 2024