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Network pharmacological analysis and experimental study of cucurbitacin B in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a malignant tumor with a high incidence and poor prognosis. Cucurbitacin B (CuB) is a tetracyclic triterpenoid...
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ZNF677 inhibits oral squamous cell carcinoma growth and tumor stemness by regulating FOXO3a
Oral squamous cell carcinoma (OSCC) is a common cancer with an increasing incidence worldwide. Zinc-finger proteins 677 (ZNF677) is involved in the...
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Chemerin promotes invasion of oral squamous cell carcinoma by stimulating IL-6 and TNF-α production via STAT3 activation
AimsElevated levels of adipokine chemerin have been identified in oral squamous cell carcinoma (OSCC) and found to be associated with metastasis to...
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FOXD1 promotes EMT and cell stemness of oral squamous cell carcinoma by transcriptional activation of SNAI2
BackgroundEpithelial-mesenchymal transition (EMT) and cell stemness are implicated in the initiation and progression of oral squamous cell carcinoma...
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Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma
Ubiquitination is a reversible process that not only controls protein synthesis and degradation, but also is essential for protein transport,...
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miR-30e-5p-mediated FOXD1 promotes cell proliferation by blocking cellular senescence and apoptosis through p21/CDK2/Rb signaling in head and neck carcinoma
Forkhead box D1 (FOXD1) belongs to the FOX protein family, which has been found to function as a oncogene in multiple cancer types, but its role in...
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Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinoma
Extracellular vesicles (EVs) have recently received increasing attention as essential mediators of communication between tumor cells and their...
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MicroRNA-1271-5p suppresses the proliferation, invasion and migration of oral squamous cell carcinoma by inhibiting F13A1 expression
BackgroundMiR-1271-5p and coagulation factor XIII A (F13A1) are reported to be associated with the malignant progression of various types of cancers....
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The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs
Cyclin-dependent kinase 2-associated protein 1 ( CDK2AP1 ; also known as deleted in oral cancer or DOC1 ) is a tumor suppressor gene known to play...
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Neutrophil extracellular traps promote invasion and metastasis via NLRP3-mediated oral squamous cell carcinoma pyroptosis inhibition
Neutrophil extracellular traps (NETs) are reticular structures composed of neutrophil elastase (NE), cathepsin G (CG) and DNA-histone enzyme...
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Histone methyltransferase KMT2D cooperates with MEF2A to promote the stem-like properties of oral squamous cell carcinoma
BackgroundEpigenetic reprogramming is involved in multiple steps of human cancer evolution and is mediated by a variety of chromatin-modifying...
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CAV2 promotes the invasion and metastasis of head and neck squamous cell carcinomas by regulating S100 proteins
More than half of HNSCC patients are diagnosed with advanced disease. Locally advanced HNSCC is characterized by tumors with marked local invasion...
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EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma
Ephrin receptor A2 (EphA2), a member of the Ephrin receptor family, is closely related to the progression of oral squamous cell carcinoma (OSCC)....
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Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival
Peroxiredoxin 1 (Prdx1), a vital antioxidant enzyme, has been proven to play an important role in the occurrence and development of cancers, but its...
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High-throughput microarray reveals the epitranscriptome-wide landscape of m6A-modified circRNA in oral squamous cell carcinoma
BackgroundEmerging transcriptome-wide high-throughput screenings reveal the landscape and functions of RNAs, such as circular RNAs (circRNAs), in...
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Expression of miR-720 is correlated with DNMT3 in Oral squamous cell carcinomas
BackgroundMany factors are involved with cellular differentiation and pluripotency, such as long non-coding and microRNAs (miRNA). miR-720 has been...
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The interplay of cytokine signaling and non-coding RNAs in head and neck squamous cell carcinoma pathobiology
Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer-related death worldwide. Despite aggressive treatment approaches, the...
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Bioinformatic analysis and experimental validation of cuproptosis-related LncRNA as a novel biomarker for prognosis and immunotherapy of oral squamous cell carcinoma
BackgroundThe novel form of regulatory cell death, cuproptosis, is characterized by proteotoxicity, which ultimately leads to cell death. Its...
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Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma
For head and neck squamous cell carcinoma (HNSCC), the local invasion and distant metastasis represent the predominant causes of mortality. Targeted...
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Gastrodin overcomes chemoresistance via inhibiting Skp2-mediated glycolysis
Aerobic glycolysis, a typical phenotype in human tumors, is associated with tumor progression and chemotherapy resistance. The present study...
