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“Bone-SASP” in Skeletal Aging
Senescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated...
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The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
BackgroundThe global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases....
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ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation
Cellular senescence is closely related to tissue aging including bone. Bone homeostasis is maintained by the tight balance between bone-forming...
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Anti-SASP and anti-inflammatory activity of resveratrol, curcumin and β-caryophyllene association on human endothelial and monocytic cells
A challenging and promising new branch of aging-related research fields is the identification of natural compounds able to modulate the...
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The Senescence-Associated Secretory Phenotype: Induction, Regulation, Function and Therapeutic Interventions to Counteract the Negative Effects
Aging is characterized by a status of chronic low-grade systemic inflammation called “inflammaging”, that represents a leading cause of diseases...
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Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging
Aging negatively affects the appearance and texture of the skin owing to the accumulation of senescent fibroblasts within the dermis. Senescent cells...
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Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors
BackgroundHuman primary hepatocytes (PHCs) are considered to be the best cell source for cell-based therapies for the treatment of end-stage liver...
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Inhibition of EZH2 alleviates SAHA-induced senescence-associated secretion phenotype in small cell lung cancer cells
Chemotherapy has been widely used in small cell lung cancer (SCLC) treatment in the past decades. However, SCLC is easy to recur after chemotherapy....
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The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21,...
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TEAD4 antagonizes cellular senescence by remodeling chromatin accessibility at enhancer regions
Dramatic alterations in epigenetic landscapes are known to impact genome accessibility and transcription. Extensive evidence demonstrates that...
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Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for develo** new senotherapeutics
DNA damage resulting from genotoxic injury can initiate cellular senescence, a state characterized by alterations in cellular metabolism, lysosomal...
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TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation
Sterile inflammation, also known as ‘inflammaging’, is a hallmark of tissue aging. Cellular senescence contributes to tissue aging, in part, through...
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IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors
Cells that are exposed to harmful genetic damage, either from internal or external sources, may undergo senescence if they are unable to repair their...
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RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells
Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the...
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Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging
Cellular senescence is a stress-induced, permanent cell cycle arrest involved in tumor suppression and aging. Senescent cells secrete bioactive...
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Analysis of the relationship between age-related erythrocyte dysfunction and fatigue
With the declining birth rates and aging societies in developed countries, the average age of the working population is increasing. Older people tend...
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Nifuroxazide boosts the anticancer efficacy of palbociclib-induced senescence by dual inhibition of STAT3 and CDK2 in triple-negative breast cancer
Though palbociclib, a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor has been approved for treating breast cancer, two major clinical challenges...
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Effect of miR-21 in mesenchymal stem cells-derived extracellular vesicles behavior
BackgroundA challenging new branch of research related to aging-associated diseases is the identification of miRNAs capable of modulating the...
