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SARS-CoV-2 RNA Genome
Coding regionsCoding regions of the genome are translated into several non-structural proteins, as well as into the widely studied spike protein,... -
Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV across mammals
Exploring wild reservoirs of pathogenic viruses is critical for their long-term control and for predicting future pandemic scenarios. Here, a...
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Antigenic Cartography of SARS-CoV-2
AbstractAntigenic cartography is a tool for interpreting and visualizing antigenic differences between virus variants based on virus neutralization...
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Immunology of SARS-CoV-2 Infection
AbstractAccording to the data from the World Health Organization, about 800 million of the world population had contracted coronavirus infection...
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Genetic analysis of ACE2 peptidase domain in SARS-CoV-2-positive and SARS-CoV-2-negative individuals from Pakistan
BackgroundThe outbreak of coronavirus disease 2019 (COVID-19) has emerged as a serious public health emergency of global concern. Angiotensin...
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Characterization of the Ubiquitin and ISG15 Deconjugase Activity of SARS-CoV-1 and SARS-CoV-2 Papain-Like Protease
Both severe acute respiratory syndrome coronavirus 1 and 2 (SARS-CoV-1 and SARS-CoV-2) encode a papain-like protease (PLpro), which plays a vital... -
SARS-CoV-2 biology and host interactions
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic...
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Persistence of SARS-CoV-2 Antibodies for a Year Following SARS-CoV-2 Vaccinations (BBV152 and ChAdOx1 nCoV-19)
The first two vaccines administered in the COVID-19 vaccination campaign of India were Covaxin (BBV152) and Covishield (ChAdOx1-nCoV-19). In this...
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Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with short- and long-term neurological complications. The...
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SARS-CoV-2 and Microbiota
Today, the globe is dealing with the COVID-19 epidemic, which poses a pandemic danger. This infectious disease is triggered by severe acute... -
The Evolution of SARS-CoV-2
Species evolve over time and viruses are no exception. Extensive genome sequencing of SARS-CoV-2 throughout the global pandemic has allowed for... -
Age-specific nasal epithelial responses to SARS-CoV-2 infection
Children infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk of mortality in infected people over 85 years of age...
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SARS-CoV-2 evolution in the Omicron era
Since SARS-CoV-2 BA.5 (Omicron) emerged and spread in 2022, Omicron lineages have markedly diversified. Here we review the evolutionary trajectories...
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Modeling of SARS-CoV-2 Virus Proteins: Implications on Its Proteome
COronaVIrus Disease 19 (COVID-19) is a severe acute respiratory syndrome (SARS) caused by a group of beta coronaviruses, SARS-CoV-2. The SARS-CoV-2... -
A Method to Monitor Activity of SARS-CoV-2 Nsp3 from Cells
SARS-CoV-2 protease Nsp3 is a therapeutic target for develo** anti-SARS-CoV-2 drugs. Nsp3 is a large multi-spanning membrane protein, and its... -
The evolution of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of deaths and substantial morbidity worldwide. Intense scientific...
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Generation of quality-controlled SARS-CoV-2 variant stocks
One of the main challenges in the fight against coronavirus disease 2019 (COVID-19) stems from the ongoing evolution of severe acute respiratory...
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A viral assembly inhibitor blocks SARS-CoV-2 replication in airway epithelial cells
The ongoing evolution of SARS-CoV-2 to evade vaccines and therapeutics underlines the need for innovative therapies with high genetic barriers to...
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Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies
As new variants of SARS-CoV-2 continue to emerge, it is important to assess the cross-neutralizing capabilities of antibodies naturally elicited...
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Large-Scale Culture and Plasmid Preparation Procedure for Low-Yield Bacmids Containing Full-Length SARS-CoV-2 cDNAs
Reverse genetic methods to manipulate viral genomes are key tools in modern virological experimentation. They allow for the generation of reporter...