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A host blood transcriptional signature differentiates multi-drug/rifampin-resistant tuberculosis (MDR/RR-TB) from drug susceptible tuberculosis: a pilot study
BackgroundTuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis is one of the top thirteen causes of death worldwide. The major...
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Detection of Isoniazid and Rifampin Resistance in Mycobacterium tuberculosis Clinical Isolates from Sputum Samples by High-Resolution Melting Analysis
The effective management of multidrug-resistant tuberculosis (MDR-TB) and the need for rapid and accurate screening of rifampin (RIF) and isoniazid...
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Clostridium, Bacteroides and Prevotella associates with increased fecal metabolites Trans-4-Hydroxy-L-proline and Genistein in active pulmonary tuberculosis patients during anti-tuberculosis chemotherapy with isoniazid-rifampin-pyrazinamide-ethambutol (HRZE)
PurposeTo investigated the changes of gut microbiome and fecal metabolome during anti-tuberculosis chemotherapy with isoniazid (H)-rifampin...
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Molecular identification of multiple drug resistance (MDR) strain of Mycobacterium tuberculosis
Background and ObjectivesIsoniazid and rifampin are the first -line drugs against Mycobacterium tuberculosis . Resistance to these important drugs is...
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PCR Development for Analysis of Some Type II Toxin–Antitoxin Systems, relJK, mazEF3, and vapBC3 Genes, in Mycobacterium tuberculosis and Mycobacterium bovis
Toxin–Antitoxin (TA) systems are some small genetic modules in bacteria that play significant roles in resistance and tolerance development to...
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Potential Use of Mycobacterium paragordonae for Antimycobacterial Drug Screening Systems
Our recent genome-based study indicated that Mycobacterium paragordonae (Mpg) has evolved to become more adapted to an intracellular lifestyle within...
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Rifampin resistance and its fitness cost in Riemerella anatipestifer
BackgroundRiemerella anatipestifer ( R. anatipestifer ) is one of the most important poultry pathogens worldwide, with associated infections causing...
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Asiaticoside A for the modulation of 1-TbAd- a potential target and ligand for extensive drug resistance Mycobacterium tuberculosis
In nature, terpene nucleosides are relatively rare, with 1-tuberculosinyladenosine (1-TbAd) being an exclusive feature of Mycobacterium tuberculosis ...
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Unveiling the repressive mechanism of a PPS-like regulator (PspR) in polyhydroxyalkanoates biosynthesis network
AbstractPoly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) is a type of polyhydroxyalkanoates (PHA) that exhibits numerous outstanding properties...
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Epidemiological characterization of clinical isolates of meticillin resistant Staphylococcus aureus through multilocus sequence ty** and staphylococcal cassette chromosome mec ty** in Northwest Iran
BackgroundMethicillin-resistant Staphylococcus aureus (MRSA), is considered a potential and aggressive nosocomial pathogen. It accounts for 50% of S....
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Screening of pslA and pelB Biofilm-Producing Genes from Pseudomonas Isolated from Clinical Samples
The Pseudomonas aeruginosa bacterium, which is considered a nosocomial infectious agent, changes its structure due to exposure to various antibiotics...
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Investigation and characterization of Aliarcobacter spp. isolated from cattle slaughterhouse in Türkiye
Aliarcobacter spp. have been isolated from numerous food products at retail and from animal carcasses and feces at slaughter. The objectives of this...
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Evaluation of a novel inhibitor of aspartate semialdehyde dehydrogenase as a potent antitubercular agent against Mycobacterium tuberculosis
The in vitro activity of IMB-XMA0038, a novel inhibitor targeting Mycobacterial tuberculosis ( Mtb ) aspartate semialdehyde dehydrogenase, was...
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Abundant resistome determinants in rhizosphere soil of the wild plant Abutilon fruticosum
A metagenomic whole genome shotgun sequencing approach was used for rhizospheric soil micribiome of the wild plant Abutilon fruticosum in order to...
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In vitro assessment of 17 antimicrobial agents against clinical Mycobacterium avium complex isolates
BackgroundRecently, Mycobacterium avium complex (MAC) infections have been increasing, especially in immunocompromised and older adults. The rapid...
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Genetic diversity of drug-resistant Mycobacterium tuberculosis clinical isolates from Khuzestan province, Iran
The emergence of drug-resistant strains of the Mycobacterium tuberculosis (MTB) has challenged tuberculosis control programs. So far, few studies...
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Comparative genomics analysis of Streptococcus iniae isolated from Trachinotus ovatus: novel insight into antimicrobial resistance and virulence differentiation
BackgroundStreptococcus iniae is an important fish pathogen that cause significant economic losses to the global aquaculture industry every year....
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Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hainan, China: from 2014 to 2019
BackgroundThe emergence of antimicrobial resistance against Mycobacterium tuberculosis ( M. tuberculosis ) has become the major concern in global...
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Tripleurospermum disciforme (C.A.Mey.) Sch.Bip., Tanacetum parthenium (L.) Sch.Bip, and Achillea biebersteinii Afan.: efficiency, chemical profile, and biological properties of essential oil
BackgroundTripleurospermum disciforme (C.A.Mey.) Sch.Bip., Tanacetum parthenium (L.) Sch.Bip., and Achillea biebersteinii Afan. are the most...
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Effect of different drugs and drug combinations on killing stationary phase and biofilms recovered cells of Bartonella henselae in vitro
BackgroundBartonella henselae is a Gram-negative bacterium transmitted to humans by a scratch from cat in the presence of ectoparasites. Humans...
