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Airway microecology in rifampicin-resistant and rifampicin-sensitive pulmonary tuberculosis patients
BackgroundPulmonary tuberculosis is a chronic infectious disease of the respiratory system. It is still one of the leading causes of death from a...
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Statistical analysis of 914 Mycobacterium tuberculosis genomes reveals single nucleotide polymorphisms in the ponA1 gene associated with rifampicin resistance
Rifampicin resistance in Mycobacterium tuberculosis represents a big public health problem and the ponA1 gene could be related to this. Our study...
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Therapeutic Potential of Morin Hydrate Against Rifampicin Induced Hepato and Renotoxicity in Albino Wistar Rats: Modulation of Organ Function, Oxidative Stress and Inflammatory Response
Tuberculosis (TB) is a challenging public health issue, particularly in poor and develo** countries. Rifampicin (RIF) is one of the most common...
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Potent Rifampicin derivatives can clear MRSA infections at single low doses when concomitantly dosed with Vancomycin
For a number of years, antimicrobial resistance (AMR) has been a critical issue for humanity. Drug discovery efforts have been very limited and the...
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Involvement of the SCO3366 efflux pump from S. coelicolor in rifampicin resistance and its regulation by a TetR regulator
AbstractOverexpression of efflux pumps represents a key mechanism of resistance in bacteria. Soil bacteria such as Streptomyces harbour a vast array...
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Activation of the SigE-SigB signaling pathway by inhibition of the respiratory electron transport chain and its effect on rifampicin resistance in Mycobacterium smegmatis
Using a mutant of Mycobacterium smegmatis lacking the major aa 3 cytochrome c oxidase of the electron transport chain (Δ aa 3 ), we demonstrated that...
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MazEF-rifampicin interaction suggests a mechanism for rifampicin induced inhibition of persisters
BackgroundPersistence is a natural phenomenon whereby a subset of a population of isogenic bacteria either grow slow or become dormant conferring...
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Nanoparticles of Lactic Acid Polymer with Rifampicin Decrease the P-gp Multidrug Transporter Activity in Human Macrophages
Abstract —The problem of reduced effectiveness of antituberculosis drugs is currently associated not only with the development of drug resistance in...
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Insight rifampicin-resistant (rpoB) mutation in Pseudomonas stutzeri leads to enhance the biosynthesis of secondary metabolites to survive against harsh environments
In this study, a wild-type and five distinct rifampicin-resistant (Rif r ) rpoB mutants of Pseudomonas stutzeri (i.e., Q518R, D521Y, D521V, H531R and...
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Effects of rifampicin on hepatic antioxidant enzymes in PXR and CAR double humanized mice
BackgroundNuclear receptor are major regulators of hepatic drug metabolizing enzymes and antioxidants enzymes. Nuclear receptor humanized mice were...
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A Microtiter Plate Assay at Acidic pH to Identify Potentiators that Enhance Pyrazinamide Activity Against Mycobacterium tuberculosis
Pyrazinamide (PZA) is a key component of chemotherapy for the treatment of drug-susceptible tuberculosis (TB) and is likely to continue to be...
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Predicting rifampicin resistance mutations in bacterial RNA polymerase subunit beta based on majority consensus
BackgroundMutations in an enzyme target are one of the most common mechanisms whereby antibiotic resistance arises. Identification of the resistance...
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Antimicrobial susceptibility of Rhodococcus equi strains isolated from foals in Chile
Rhodococcus equi is responsible for foal pneumonia worldwide, with a significant economic impact on the production and breeding of horses. In Chile,...
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Mutational Improvement of the Lactobacillus delbrueckii subsp. lactis Biopreservation Potential
AbstractThe primary objective of this study was to develop tools and strategies aimed at enhancing the synthesis of hydrogen peroxide in Lactobacillus...
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Improved RNA stability estimation indicates that transcriptional interference is frequent in diverse bacteria
We used stochastic simulations and experimental data from E. coli , K. aerogenes , Synechococcus PCC 7002 and Synechocystis PCC 6803 to provide...
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Characterization of mutations in the rpoB gene conferring rifampicin resistance in Mycobacterium tuberculosis complex isolated from lymph nodes of slaughtered cattle from South Africa
Tuberculosis (TB) is an ongoing public health care, with the state of affairs exacerbated by the growth of anti-TB drug-resistant forms in South...
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Assessment of the GenoType MTBDRsl VER 2.0 compared to the phenotypic drug susceptibility testing and whole genome sequencing for the rapid detection of resistance to fluoroquinolone and second-line injectable drugs among rifampicin-resistant Mycobacterium tuberculosis isolates
Molecular techniques have considerable advantages for rapid detection, a reduction of infectiousness, prevention of further resistance development...
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A cell-free strategy for host-specific profiling of intracellular antibiotic sensitivity and resistance
Antimicrobial resistance (AMR) is a pandemic spread across multiple infectious disease-causing microbes. To provide a host-specific tool to study...
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Characteristics of Clostridioides difficile isolates circulating in the Slovak hospitals
Clostridioides difficile is a frequent cause of hospital-acquired diarrhea associated with antibiotics. Hypervirulent strains of Clostridioides...
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Detection of mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains inhibiting wild type probe hybridization in the MTBDR plus assay by DNA sequencing directly from clinical specimens
BackgroundThe potential of genetic testing for rapid and accurate diagnosis of drug-resistant Mycobacterium tuberculosis strains is vital for...
