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PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model
Age-related macular degeneration (AMD) is the leading cause of irreversible vision damage among elderly individuals. There is still no efficient...
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Conservatism and Variability of the Antioxidant Defense System in the Retinal Pigment Epithelium of Vertebrates
AbstractDuring evolution and adaptation to life conditions, organisms have developed the strategies allowing them to use reactive oxygen species...
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Comparative 3D genome analysis between neural retina and retinal pigment epithelium reveals differential cis-regulatory interactions at retinal disease loci
BackgroundVision depends on the interplay between photoreceptor cells of the neural retina and the underlying retinal pigment epithelium (RPE). Most...
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DAPL1 prevents epithelial–mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy
Epithelial–mesenchymal transition (EMT) of the retinal pigment epithelium (RPE) is a hallmark of the pathogenesis of proliferative vitreoretinopathy...
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Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium
Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical...
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Dynamic full-field optical coherence tomography allows live imaging of retinal pigment epithelium stress model
Retinal degenerative diseases lead to the blindness of millions of people around the world. In case of age-related macular degeneration (AMD), the...
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Single-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin
Cellular senescence of the retinal pigment epithelium (RPE) is thought to play an important role in vision-threatening retinal degenerative diseases,...
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Photobiology of lipofuscin granules in the retinal pigment epithelium cells of the eye: norm, pathology, age
Lipofuscin granules (LGs) are accumulated in the retinal pigment epithelium (RPE) cells. The progressive LG accumulation can somehow lead to...
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Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages
BackgroundRecently, great efforts have been made to design protocols for obtaining ocular cells from human stem cells to model diseases or for...
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Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
Retinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal disorders such as retinal degeneration (RD) and...
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Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa
BackgroundRetinitis pigmentosa (RP) is an inherited retinal disease that results in photoreceptor degeneration, leading to severe vision loss or...
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Human Wharton’s Jelly Mesenchymal Stem Cell Secretome Modifies the Processes of Neuroprotection and Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium at Transcriptional Level
BackgroundRetinal pigment epithelium (RPE) cells are potential targets for treating retinal detachment (RD) and proliferative vitreoretinopathy...
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Epithelial-Mesenchymal Transition: Molecular Mechanisms of Retinal Pigment Epithelial Cell Activation
AbstractActivated cells of human retinal pigment epithelium (RPE) are the main effector cells in the process of fibrosis, the main pathological...
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Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration
Non-exudative age-related macular degeneration (NE-AMD), the main cause of blindness in people above 50 years old, lacks effective treatments at the...
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Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly. Progressive dystrophy of the retinal pigment epithelium...
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Small Noncoding RNA in Regulation of Differentiation of Retinal Pigment Epithelium
AbstractDedifferentiation and epithelial-mesenchymal transition (EMT) of human retinal pigment epithelial (RPE) cells, as well as the participation...
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Application of Human Stem Cell Derived Retinal Organoids in the Exploration of the Mechanisms of Early Retinal Development
The intricate neural circuit of retina extracts salient features of the natural world and forms bioelectric impulse as the origin of vision. The...
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Early Appearance of Aging Signs in the Retinal Pigment Epithelium in Young Albino Rats
AbstractRetinal pigment epithelium (RPE), whose main functions are to participate directly in light perception and ensure the trophic and functioning...
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Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration
BackgroundAge-related macular degeneration (AMD) is a result of degeneration/damage of the retinal pigment epithelium (RPE) while retinitis...
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Human-induced pluripotent stem cells-derived retinal pigmented epithelium, a new horizon for cells-based therapies for age-related macular degeneration
Retinal pigment epithelium (RPE) degeneration is the hallmark of age-related macular degeneration (AMD). AMD, as one of the most common causes of...
