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Introduction of a Sodium-Binding Motif into Subunits a and c of Bacillus sp. PS3 Proton F-ATPase Does Not Result in Sodium Specificity of the Enzyme
AbstractIn bacteria, F-type ATPase (F-ATPase) plays a key role in bioenergetics and couples ATP synthesis/hydrolysis with the transport of ions (H + ...
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The frequency of efflux pump genes expression in Acinetobacter baumannii isolates from pulmonary secretions
Acinetobacter baumannii is an important opportunistic pathogen, and the cause of nosocomial infections worldwide in recent decades. Efflux pumps are...
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A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity
Cancer cells are highly dependent on bioenergetic processes to support their growth and survival. Disruption of metabolic pathways, particularly by...
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Resilience and stability of the CF- intestinal and respiratory microbiome during nutritional and exercise intervention
BackgroundImpaired respiratory and intestinal microbiome composition is linked to cystic fibrosis lung disease severity. In people with cystic...
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An efflux pump in genomic island GI-M202a mediates the transfer of polymyxin B resistance in Pandoraea pnomenusa M202
BackgroundPolymyxin B is considered a last-line therapeutic option against multidrug-resistant gram-negative bacteria, especially in COVID-19...
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Fast Determination of Mitochondrial Metabolism and Respiratory Complex Activity in Permeabilized and Intact Cells
Assessment of mitochondrial metabolism is multidimensional and time consuming, usually requiring specific training. Respiration, NADH generation, and...
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Boosting intracellular sodium selectively kills hepatocarcinoma cells and induces hepatocellular carcinoma tumor shrinkage in mice
Pharmacological treatments for advanced hepatocellular carcinoma (HCC) have a partial efficacy. Augmented Na + content and water retention are...
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Architecture of bacterial respiratory chains
Bacteria power their energy metabolism using membrane-bound respiratory enzymes that capture chemical energy and transduce it by pum** protons or Na
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How SARS-CoV-2 might affect potassium balance via impairing epithelial sodium channels?
Severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) is the causative agent of current coronavirus disease 2019 (COVID-19) pandemic....
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Human placenta-derived amniotic epithelial cells as a new therapeutic hope for COVID-19-associated acute respiratory distress syndrome (ARDS) and systemic inflammation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become in the spotlight regarding...
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SARS-CoV-2 Infection of Human Primary Nasal Multiciliated Epithelial Cells Grown on Air-Liquid Interface Cultures
Respiratory epithelial cells fail to exhibit natural phenotypic and morphological characteristics when grown in standard cell culture conditions. To...
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Expansion of the “Sodium World” through Evolutionary Time and Taxonomic Space
AbstractIn 1986, Vladimir Skulachev and his colleagues coined the term “Sodium World” for the group of diverse organisms with sodium (Na)-based...
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Measurement of Fatty Acid Oxidation by High-Resolution Respirometry: Special Considerations for Analysis of Skeletal and Cardiac Muscle and Adipose Tissue
High-resolution respirometry is a state-of-the-art approach for the quantitation of mitochondrial function. Isolated mitochondria, cultured cells, or...
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Molecular biochemical aspects of salt (sodium chloride) in inflammation and immune response with reference to hypertension and type 2 diabetes mellitus
Obesity, insulin resistance, type 2 diabetes mellitus (T2DM) and hypertension (HTN) are common that are associated with low-grade systemic...
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Plant-specific features of respiratory supercomplex I + III2 from Vigna radiata
The last steps of cellular respiration—an essential metabolic process in plants—are carried out by mitochondrial oxidative phosphorylation. This...
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Effect of Sodium Ions on Calcium-Loaded Rat Heart Mitochondria and Frog Myocardium
AbstractThe effect of calcium load on rat heart mitochondria [RHM(K + )], in which K + ions in the matrix were partially replaced by Na + ions [RHM(Na + )]...
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The Effect of Azide, Fluoride, Orthovanadate and EDTA Sodium Salts on Ecto-ATPase Activity in Erythrocytes of a Scorpionfish (
Scorpaena porcus L.) and Thornback Ray (Raja clavata L.)AbstractThe effect of azide, fluoride, orthovanadate and EDTA sodium salts on the ecto-ATPase activity in erythrocytes of a scorpionfish ( Scorpaena...
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The Rnf complex is a Na+ coupled respiratory enzyme in a fermenting bacterium, Thermotoga maritima
rnf genes are widespread in bacteria and biochemical and genetic data are in line with the hypothesis that they encode a membrane-bound enzyme that...
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Characterizing the Electron Transport Chain: Structural Approach
The mitochondrial respiratory chain which carries out the oxidative phosphorylation (OXPHOS) consists of five multi-subunit protein complexes....
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Sodium Bicarbonate (NaHCO3) Increases Growth, Protein and Photosynthetic Pigments Production and Alters Carbohydrate Production of Spirulina platensis
Improving the biochemical status of Spirulina platensis will enhance the functional properties of this microalgae. The present study investigated the...
