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Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication
BackgroundAnalysis of viral protein–protein interactions is an essential step to uncover the viral protein functions and the molecular mechanism for...
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Targeting ER stress/PKA/GSK-3β/β-catenin pathway as a potential novel strategy for hepatitis C virus-infected patients
BackgroundChronic hepatitis C virus (HCV) infection causes hepatocellular carcinoma (HCC). The HCC risk, while decreased compared with active HCV...
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Intracellular common gardens reveal niche differentiation in transposable element community during bacterial adaptive evolution
The distribution and abundance of transposable elements across the tree of life have significantly shaped the evolution of cellular organisms, but...
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Burning questions for fire blight research: I. Genomics and evolution of Erwinia amylovora and analyses of host-pathogen interactions
Fire blight, caused by the bacterial pathogen Erwinia amylovora , continues to be a devastating disease affecting commercial apple and pear plantings...
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Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for genome replication
Replication of many positive-sense RNA viruses occurs within intracellular membrane-associated compartments. These are thought to provide a...
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Telomere C-Strand Fill-In Machinery: New Insights into the Human CST-DNA Polymerase Alpha-Primase Structures and Functions
Telomeres at the end of eukaryotic chromosomes are extended by a specialized set of enzymes and telomere-associated proteins, collectively termed...
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A Single Mutation in the Cryptic AUG (cAUG) Affects In Vitro Translation and Replication Efficiencies and In Vivo Virulence of Coxsackievirus B3 (CVB3)
The 5′UTR of the genomic RNA of CVB3, unusually long and rich on highly structured secondary structure, contains a conserved cis acting RNA element...
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Genomic insights into plasmid-mediated antimicrobial resistance in the bacterium Bhargavaea bei**gensis strain PS04
The dissemination of antimicrobial-resistant bacteria through environment is a major health concern for public health. Pathogenic bacteria in natural...
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The phylogenomic landscape of extended-spectrum β-lactamase producing Citrobacter species isolated from surface water
BackgroundCitrobacter species are Gram-negative opportunistic pathogens commonly reported in nosocomial-acquired infections. This study...
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Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor
The respiratory syncytial virus polymerase complex, consisting of the polymerase (L) and phosphoprotein (P), catalyzes nucleotide polymerization, cap...
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Subfunctionalization probably drives the emergence of plant growth-promoting genes
The duplication and divergence of stress-related genes might help microbes adapt to different environments. However, little is known about this type...
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Genomic and proteomic analysis of Salmonella Enteritidis isolated from a patient with foodborne diarrhea
Salmonella is a major cause of foodborne diseases and clinical infections worldwide. This study aimed to investigate the drug resistance, genomic...
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A versatile nanoluciferase toolkit and optimized in-gel detection method for protein analysis in plants
Dissection of gene function requires sophisticated tools to monitor gene expression. Gene tagging with epitope peptides and fluorescent protein tags...
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Genomics analysis of KPC-2 and NDM-5-producing Enterobacteriaceae in migratory birds from Qinghai Lake, China
AbstractThe study examined the epidemiological characteristics of carbapenem-resistant Enterobacteriaceae (CRE) isolated from migratory birds and...
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A small bacteriophage protein determines the hierarchy over co-residential jumbo phage in Bacillus thuringiensis serovar israelensis
Bacillus thuringiensis serovar israelensis is the most widely used biopesticide against insects, including vectors of animal and human diseases....
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Contribution of RNA Species in Sexually Transmitted Infections
Many studies have shown RNA modifications including deamination of cytosine to uracil (C-to-U), deamination of adenosine to inosine (A-to-I),...
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Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir
Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir are still needed, particularly for individuals in whom vaccines...
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Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
Replication of viruses requires interaction with host cell factors and repression of innate immunity. Recent findings suggest that a subset of...
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Fibroblast Growth Factor 11 Inhibits Hepatitis B Virus Gene Expression Through FXRα Suppression
Fibroblast growth factor 11 (FGF11) is a member of the intracellular FGF family, which shows different signal transmission compared with other FGF...
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Genome-wide identification of Azospirillum brasilense Sp245 small RNAs responsive to nitrogen starvation and likely involvement in plant-microbe interactions
BackgroundSmall RNAs (sRNAs) are non-coding RNAs known to regulate various biological functions such as stress adaptation, metabolism, virulence as...
