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Biochemical and Histological Studies on the Protective Effects of Curcumin against Acetamiprid-Induced Hepato-Renal Toxicity
AbstractThe present study aims to investigate the possible liver and kidney toxicity mechanisms of prolonged acetamiprid (ACMP) induction and the...
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Development of an In Vitro Model for Inflammation Mediated Renal Toxicity Using 3D Renal Tubules and Co-Cultured Human Immune Cells
Background: The emergence of various infectious diseases and the toxic effects of hyperinflammation by biotherapeutics have highlighted the need for in...
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Cyto and Genoprotective Potential of Tannic Acid Against Cadmium and Nickel Co-exposure Induced Hepato-Renal Toxicity in BALB/c Mice
Tannic acid (TA) is a metal chelating polyphenol that plays a crucial role in metal detoxification, but its modulatory role in co-exposure of these...
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Tungsten toxicity on kidney tubular epithelial cells induces renal inflammation and M1-macrophage polarization
Tungsten is widely used in medical, industrial, and military applications. The environmental exposure to tungsten has increased over the past several...
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The Role of Phthalocyanine-Gold Nanoconjugates (Pc-Au NCs) in Ameliorating the Hepatic and Renal Toxicity-Induced by Silver Nanoparticles (Ag NPs) in Male Rats
Recently, gold nanoparticles (Au Nps) have gained tremendous attention for its unique properties as a safe nanocarrier for delivering drugs that are...
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A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes
BackgroundPeople of Sub-Saharan African ancestry are at higher risk of develo** chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (
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Mitochondrial transplantation against gentamicin-induced toxicity on rat renal proximal tubular cells: the higher activity of female rat mitochondria
Mitochondrial dysfunction is a fundamental mechanism leading to drug nephrotoxicity, such as gentamicin-induced nephrotoxicity. Mitochondrial therapy...
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Scopoletin alleviates high glucose-induced toxicity in human renal proximal tubular cells via inhibition of oxidative damage, epithelial-mesenchymal transition, and fibrogenesis
BackgroundRecent years of evidence suggest the crucial role of renal tubular cells in develo** diabetic kidney disease. Scopoletin (SCOP) is a...
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Zinc Oxide Nanoparticles Induce Renal Injury by Initiating Oxidative Stress, Mitochondrial Damage and Apoptosis in Renal Tubular Epithelial Cells
Zinc oxide nanoparticles (ZnO NPs) are widely used in many fields due to their unique physicochemical properties. However, the renal toxicity of ZnO...
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Naringenin alleviates hyperglycemia-induced renal toxicity by regulating activating transcription factor 4–C/EBP homologous protein mediated apoptosis
Endoplasmic reticulum (ER) dysfunction plays a prominent role in the pathophysiology of diabetic nephropathy (DN). This study aimed to investigate...
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Nephroprotective Efficacy of Selenium and Zinc Against Potassium Dichromate-Induced Renal Toxicity in Pregnant Wistar Albino Rats
Hexavalent chromium (CrVI) compounds are potent toxicants commonly used in numerous industries. Thus, potential toxic effects and health hazards are...
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VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2α
BackgroundRenal fibrosis is the pathological foundation of various chronic kidney diseases progressing to end stage renal failure. However, there are...
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Cadmium toxicity and autophagy: a review
Cadmium (Cd) is an important environmental pollutant that poses a threat to human health and represents a critical component of air pollutants, food...
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Impact of Chronic Sodium Fluoride Toxicity on Antioxidant Capacity, Biochemical Parameters, and Histomorphology in Cardiac, Hepatic, and Renal Tissues of Wistar Rats
The study was designed to determine the fluoride distribution after its oral exposure in drinking water and its associated impact on biochemical,...
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Therapeutic applications of carbon nanomaterials in renal cancer
Carbon nanomaterials (CNMs), including carbon nanotubes (CNTs), graphene, and nanodiamonds (NDs), have shown great promise in detecting and treating...
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The Effect of Usnic Acid and Alphalypoic Acid on Changes Occurring in Cell Mitogenic Activity Proteins in Liver and Kidney Tissue of Cadmium Toxicity-Supplied Rats
AbstractThis study aimed to investigate the protective effects of usnic acid and alpha lipoic acid on changes in cellular mitogenic activity proteins...
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Ecliptasaponin A attenuates renal fibrosis by regulating the extracellular matrix of renal tubular cells
Renal fibrosis is the most common manifestation of end-stage renal disease (ESRD), including diabetic kidney disease (DKD), but there is no effective...
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The Regenerative Potential of Human Adult Renal Stem/Progenitor Cells
The human adult renal stem/progenitor cells (ARPCs) play a role in renal regeneration in two ways: by differentiating directly or by secreting...
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Probiotics for the Abrogation Arsenic Toxicity: A review
Arsenic toxicity, principally by polluted groundwater, is regarded as a momentous global public health risk, as there is no particular and proven...
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Eltroxin and Hesperidin mitigate testicular and renal damage in hypothyroid rats: amelioration of oxidative stress through PPARγ and Nrf2/HO-1 signaling pathway
BackgroundThyroid hormones (THs) regulate growth, development and function of different tissues. Hypothyroidism is a common clinical disorder...
