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Effects of Dihydroquercetin on the Intensity of Oxydative Stress in Rat Liver Mitochondria at Hypothermia
AbstractA decrease in body temperature in homeothermic animals can cause a state of the body called hypothermic. It is accompanied by the development...
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Calcium-Accumulating Ability of Rat Liver Mitochondria in Hypothermia of Various Duration
AbstractCalcium is one of the most important intracellular messengers that regulate physiological and biochemical processes in the cell. Mitochondria...
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Torpid 13-lined ground squirrel liver mitochondria resist anoxia-reoxygenation despite high levels of protein damage
Hibernation confers resistance to ischemia–reperfusion injury in tissue, but the underlying mechanisms remain unclear. Suppression of mitochondrial...
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Functional activity and morphology of isolated rat cardiac mitochondria under calcium overload. Effect of naringin
The function of mitochondria as a regulator of myocyte calcium homeostasis has been extensively discussed. The aim of the present work was further...
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Liver sinusoidal endothelial cells rely on oxidative phosphorylation but avoid processing long-chain fatty acids in their mitochondria
BackgroundIt is generally accepted that endothelial cells (ECs), primarily rely on glycolysis for ATP production, despite having functional...
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Effect of Glucocorticoid Deflazacort on Respiration and Calcium-Dependent Permeability of Rat Liver Mitochondria
Abstract —This study examines the effect of glucocorticoid deflazacort on the functioning of rat liver mitochondria. Deflazacort at concentrations up...
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Effect of Methyltriclosan on the Functioning of Isolated Rat Liver Mitochondria and Permeability of Liposomal Membranes
AbstractEffects of methyltriclosan, a biodegradation product of the antimicrobial agent triclosan, on the functional parameters of rat liver...
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Mitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice
Reactive oxygen species (ROS) can induce oxidative injury and are generally regarded as toxic byproducts, although they are increasingly recognized...
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The effects of restraint stress on ceramide metabolism disorders in the rat liver: the role of CerS6 in hepatocyte injury
BackgroundStress is implicated in various pathological conditions leading to liver injury. Existing evidence suggests that excessive stress can...
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Protective Effects of Alpha Lipoic Acid Against Arsenic Induced Oxidative Stress in Isolated Rat Liver Mitochondria
Arsenic as a heavy metal and toxic pollutant has been established that has the hepatotoxic effect in animal and human models. Previous studies showed...
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Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue
BackgroundMetabolic associated fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, and it is also a high-risk...
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Isolation of Mitochondria from Mouse Tissues for Functional Analysis
Methods for isolating mitochondria from different rodent tissues have been established for decades. Although the general principles for crude...
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Effects of Tl+ on the inner membrane thiol groups, respiration, and swelling in succinate-energized rat liver mitochondria were modified by thiol reagents
The effects of both Tl + and thiol reagents were studied on the content of the inner membrane free SH-groups, detected with Ellman reagent, and the...
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Proteome profiling, biochemical and histological analysis of diclofenac-induced liver toxicity in Yersinia enterocolitica and Lactobacillus fermentum fed rat model: a comparative analysis
Diclofenac is a hepatotoxic non-steroidal anti-inflammatory drug (NSAID) that affects liver histology and its protein expression levels. Here, we...
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Mitochondria as a target for exercise-mitigated type 2 diabetes
Type 2 diabetes mellitus (T2DM) is one of most common metabolic diseases and continues to be a leading cause of death worldwide. Although great...
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Effect of Sodium Ions on Calcium-Loaded Rat Heart Mitochondria and Frog Myocardium
AbstractThe effect of calcium load on rat heart mitochondria [RHM(K + )], in which K + ions in the matrix were partially replaced by Na + ions [RHM(Na + )]...
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Quantitative Proteomics Analysis of Purified Rat Liver Golgi
The Golgi is the central organelle in the secretory pathway, essential for post-translational modifications, sorting and trafficking of secretory and...
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The Role of the Phosphate Carrier in the Ionophore Uncoupling Action of ω-Hydroxypalmitic Acid in Liver Mitochondria
AbstractThis paper examines the uncoupling effect of ω-hydroxypalmitic acid (HPA) on liver mitochondria energized by oxidation of succinate. It was...
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Comparative Assessment of the Functional Activity of Rat Epididymal Mitochondria in Oxidative Stress Induced by Hyperhomocysteinemia and L-NAME Administration
AbstractThe state of protein carbonylation with the determination of the adaptive reserve potential and analysis of the proportion of primary and...
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Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury
Acetaminophen (APAP) overdose is a common cause of drug-induced liver injury (DILI). Ferroptosis has been recently implicated in APAP-induced liver...
