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1. SB431542 partially inhibits high glucose-induced EMT by restoring mitochondrial homeostasis in RPE cells

   Background

   The epithelial–mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells participated in the development of retinal fibrosis....

   **g**g Cao, Mingfei Jiao, ... Lijie Dong in Cell Communication and Signaling

   Article Open access 05 January 2024
   

2. Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia

   Age-related macular degeneration (AMD) is the most common blinding disease in the elderly population. However, there are still many uncertainties...

   Yoshiyuki Henning, Katrin Willbrand, ... Johann Matschke in Cell Death Discovery

   Article Open access 25 October 2023
   

3. IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation

   Retinal degeneration is a kind of neurodegeneration characterized by progressive neuronal death and dysfunction of retinal pigment epithelium (RPE)...

   Tian Zhou, Ziqi Yang, ... **alin Liu in Cell Death & Disease

   Article Open access 20 December 2022
   

4. Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction

   Oxidative stress and hypoxia in the retinal pigment epithelium (RPE) have long been considered major risk factors in the pathophysiology of...

   Yoshiyuki Henning, Ursula Sarah Blind, ... Joachim Fandrey in Cell Death & Disease

   Article Open access 29 July 2022
   

5. Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration

   Background

   Age-related macular degeneration (AMD), characterized by the degeneration of retinal pigment epithelium (RPE) and photoreceptors, is the...

   Wenchang Xu, **nqi Liu, ... Ling Zhao in Cell Communication and Signaling

   Article Open access 14 June 2023
   

6. Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy

   Diabetic Retinopathy (DR) is a complication of diabetes that causes blindness in adults. Retinal fibrosis is closely associated with develo**...

   Rachel Daley, Vishnu Maddipatla, ... Haitao Liu in Cell Death Discovery

   Article Open access 13 July 2023
   

7. Melanosome Motility in Fish Retinal Pigment Epithelial (RPE) Cells

   Several model systems have been developed to investigate mechanisms and regulation of intracellular organelle motility. The fish retinal pigment...

   Christina King-Smith in Cytoskeleton

   Protocol 2022
   

8. Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration

   Age-related macular degeneration (AMD), a leading cause of blindness, initiates in the outer-blood-retina-barrier (oBRB) formed by the retinal...

   Min Jae Song, Russ Quinn, ... Kapil Bharti in Nature Methods

   Article 22 December 2022
   

9. Degron Tagging Using mAID and SMASh Tags in RPE-1 Cells

   Degron tags allow the precise and well-controlled analysis of essential genes by rapidly inducing degradation of the protein of interest. This is...

   Adrijana Crncec, Helfrid Hochegger in Mitosis

   Protocol 2022
   

10. Cell maturation influences the ability of hESC-RPE to tolerate cellular stress

    Background

    Transplantation of human pluripotent stem cell-derived retinal pigment epithelium (RPE) is an urgently needed treatment for the cure of...

    Taina Viheriälä, Heidi Hongisto, ... Tanja Ilmarinen in Stem Cell Research & Therapy

    Article Open access 24 January 2022
    

11. SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway

    SARS-Cov-2 infection, which has caused the COVID-19 global pandemic, triggers cellular senescence. In this study, we investigate the role of the...

    Yuhang Zhang, Xuyan Peng, ... Yanzhong Hu in Biogerontology

    Article Open access 04 February 2023
    

12. Network-based inference of master regulators in epithelial membrane protein 2-treated human RPE cells

    Background

    The application of cell-specific construction of transcription regulatory networks (TRNs) to identify their master regulators (MRs) in EMP2 ...

    Hua Wan, Wei Gao, ... Jian Qin in BMC Genomic Data

    Article Open access 07 July 2022
    

13. Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model

    Background

    Human pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell replacement therapy but often lack standardized cell...

    Zeng** Liu, Tanja Ilmarinen, ... Boris V. Stanzel in Stem Cell Research & Therapy

    Article Open access 27 July 2021
    

14. Improving cell survival and engraftment in vivo via layer-by-layer nanocoating of hESC-derived RPE cells

    Background

    Human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cell transplants have served as a cell therapy for treating retinal...

    Liyan Ru, Nan Wu, ... Yong Liu in Stem Cell Research & Therapy

    Article Open access 25 November 2020
    

15. Transcriptional patterns of human retinal pigment epithelial cells under protracted high glucose

    Background

    The retinal pigment epithelium (RPE) is essential for retinal homeostasis. Comprehensively exploring the transcriptional patterns of...

    Hao Huang, **gshu Zeng, ... Huangxuan Shen in Molecular Biology Reports

    Article 04 April 2024
    

16. CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells

    Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that contributes to the...

    Rong Zhang, Lin Wang, ... Guohong Zhou in Human Cell

    Article 14 May 2024
    

17. Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration

    Age-related macular degeneration (AMD) is a major vision-threatening disease. Although mesenchymal stem cells (MSCs) exhibit beneficial neural...

    **aoman Zhu, Zhiyang Chen, ... Haibin Tian in Cell Death & Disease

    Article Open access 12 September 2022
    

18. Epithelial-mesenchymal Transition (EMT) and the Effect of Atorvastatin on it in ARPE-19 cells

    Proliferative vitreoretinopathy (PVR) develops after an unsuccessful or complicated recovery from rhegmatogenous retinal detachment (RRD) surgery....

    Yashavanthi Mysore, Maria Hytti, ... Anu Kauppinen in Cell Biochemistry and Biophysics

    Article Open access 22 May 2024
    

19. Determining the optimal stage for cryopreservation of human embryonic stem cell-derived retinal pigment epithelial cells

    Background

    Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-derived RPE) are a promising source for cell-replacement therapy...

    Ting Zhang, **anyu Huang, ... **aodong Sun in Stem Cell Research & Therapy

    Article Open access 05 September 2022
    

20. A human model of Batten disease shows role of CLN3 in phagocytosis at the photoreceptor–RPE interface

    Mutations in CLN3 lead to photoreceptor cell loss in CLN3 disease, a lysosomal storage disorder characterized by childhood-onset vision loss,...

    Cynthia Tang, Jimin Han, ... Ruchira Singh in Communications Biology

    Article Open access 05 February 2021