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Development, validation and application of RP-HPLC method for quantitative estimation of wedelolactone in different accessions and plant parts of Eclipta alba (L.)
In the current study, a simple, rapid reversed phase high performance liquid chromatographic (RP- HPLC) method was developed and validated for...
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In vitro regeneration of Piper longum L. and comparative RP-HPLC analysis of piperine production of in vitro and in vivo grown plants
Piper longum L. is a well known spice plant belonging to the family Piperaceae with high pharmacognosy potential, but it is becoming threatened due...
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RP-HPLC estimation of thermal oxidation of thymoquinone in Nigella sativa with reference to its antioxidant potential and vis-a-vis in-vitro DNA damage inhibition
Nigella sativa (NS), a popular herbal plant is known for its imperative therapeutic potentials. NS possesses active phytochemicals with unique...
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Rapid and Simple Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) Method for Simultaneous Quantifications of Triazole Antifungals in Human Serum
PurposeTo develop and validate a one-step, rapid and simple reversed-phase high-performance liquid chromatography ( HPLC)-based protocol for the...
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Determination of Drug-to-Antibody Ratio of ADCs
The drug-to-antibody ratio (DAR) refers to the number of small toxic molecules per antibody in the antibody-drug conjugates (ADCs). DAR can directly...
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Different Detection Strategies of Pediocin-Like Produced by Pediococcus pentosaceus
In this study, Pediococcus pentosaceus C-2–1 and C23221 contained genes encoding penocin and pediocin PA-1, mined by antiSMASH. The penocin...
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Genome-Based Identification and Characterization of Bacteriocins Selectively Inhibiting Staphylococcus aureus in Fermented Sausages
The bacteriocin-producing Lactiplantibacillus plantarum SL47 was isolated from conventional fermented sausages, and the bacteriocin SL47 was purified...
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Characterising avenin-like proteins (ALPs) from albumin/globulin fraction of wheat grains by RP-HPLC, SDS-PAGE, and MS/MS peptides sequencing
BackgroundWheat grain avenin-like proteins (ALPs) belong to a recently discovered class of wheat grain storage protein. ALPs in wheat grains not only...
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JZTX-V, a Sodium Channel Inhibitor, Exhibits Excellent Analgesic Effects in Mouse Models
JZTX-V, an inhibitor of voltage-gated sodium and potassium channels, is derived from the venom of the spider Chilobrachys **gzhao in China. JZTX-V...
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Isolation and Purification of an Oligopeptide from Periplaneta americana and Its Mechanism of Promoted Wound Healing
The aqueous ethanol extract of Periplaneta americana (PAE) dramatically stimulates wound healing by promoting the migration of keratinocytes. The...
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Molecular binding mechanism and novel antidiabetic and anti-hypertensive bioactive peptides from fermented camel milk with anti-inflammatory activity in raw macrophages cell lines
The investigation was to determine the effect of camel milk fermented with Limosilactobacillus fermentum KGL4 (MTCC 25515) on ACE-inhibiting,...
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A rapid and effective method for obtaining ardicrenin from Ardisia crenata Sims var. bicolor plants
Ardisia crenata Sims var. bicolor has high ornamental and medical value. To protect wild germplasm resources and obtain more ardicrenin, a plant...
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Production and characterization of a camelid single domain anti-CD22 antibody conjugated to DM1
Antibody drug conjugates (ADCs) with twelve FDA approved drugs, known as a novel category of anti-neoplastic treatment created to merge the...
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Functional expression of an antimicrobial peptide, belonging to halocin C8 family, from Natrinema sp. RNS21 in Escherichia coli
Halocins, the proteinaceous antimicrobial agents produced by haloarchaea, may be used for the preservation of salted foods and the treatment of...
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Efficacious Extraction and Purification Technique of a Potential Antimycobacterial Bacteriocin Produced by Bacillus subtilis (MK733983) of Ethnomedicinal Origin
The rapid proliferation of antibiotic-resistant microbes has imposed an urgent need for development of novel antimicrobial agents with diverse...
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Synthesis and glutathione peroxidase (GPx)-like activity of selenocystine (SeC) bioconjugates of biotin and lipoic acid
The conjugation of active biomolecules provides insight into their bioreactivity, leading to many applications in biotechnology and materials...
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Assessment of bioactive peptides derived from laminin-111 as prospective breast cancer-targeting agents
Breast cancer remains a pressing public health issue primarily affecting women. Recent research has spotlighted bioactive peptides derived from...
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Synthesis of Steroid Tracers by an Oxime Ligation Method and Their Use in Fluorescent Polarisation Immunoassay
Abstractctive: The development of a fast and reliable method for the quantitative evaluation of steroid hormones is very relevant for scientific and...
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Oxidation and reduction analysis of therapeutic recombinant human interleukin-15 by HPLC and LC-MS
AbstractBeing an important immune stimulant of T lymphocytes and NK cells, the recombinant human interleukin-15 (rhIL-15) has been extensively...
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Concentration changes in gemcitabine and its metabolites after hyperthermia in pancreatic cancer cells assessed using RP-HPLC
BackgroundGemcitabine (2′,2′-difluoro-2′-deoxycytidine;dFdC) is a first-line chemotherapy drug for pancreatic cancer. Recently, a synergistic...
