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Molecular cloning, expression and generation of a polyclonal antibody specific for RNPS1
BackgroundRNA-binding protein with serine-rich domain 1 (RNPS1) is a member of a splicing-dependent mega Dalton protein complex or exon junction...
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The exon junction complex is required for DMD gene splicing fidelity and myogenic differentiation
Deposition of the exon junction complex (EJC) upstream of exon-exon junctions helps maintain transcriptome integrity by preventing spurious...
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Nonsense-mediated mRNA decay pathway in plants under stress: general gene regulatory mechanism and advances
Main conclusionNonsense-mediated mRNA decay in eukaryotes is vital to cellular homeostasis. Further knowledge of its putative role in plant RNA...
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Large-scale transcriptome sequencing in broiler chickens to identify candidate genes for breast muscle weight and intramuscular fat content
BackgroundIn broiler production, breast muscle weight and intramuscular fat (IMF) content are important economic traits. Understanding the genetic...
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TMT quantitative proteomics reveals key proteins relevant to microRNA-1-mediated regulation in osteoarthritis
Osteoarthritis (OA) is the second-commonest arthritis, but pathogenic and regulatory mechanisms underlying OA remain incompletely understood. Here,...
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Cell cycle protein BORA is associated with colorectal cancer progression by AURORA-PLK1 cascades: a bioinformatics analysis
AbstractColorectal cancer (CRC) is the third most diagnosed cancer in the world. A better understanding of the molecular mechanism of CRC is...
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Comprehensive analysis of pre-mRNA alternative splicing regulated by m6A methylation in pig oxidative and glycolytic skeletal muscles
BackgroundDifferent types of skeletal myofibers exhibit distinct physiological and metabolic properties that are associated with meat quality traits...
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Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice
Transcriptional activation of target genes is essential for TP53-mediated tumour suppression, though the roles of the diverse TP53-activated target...
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A Study on the Role of piRNAs in Cancer Epigenetics
Piwi-interacting RNAs (piRNAs) are single-stranded, small noncoding RNAs that are 24–30 nucleotides long and have a 5′-U end and a 2′-O-methylation...
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Large-scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits
BackgroundCarcass traits are crucial indicators of meat production efficiency. However, the molecular regulatory mechanisms associated with these...
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Protein kinase CK2 – diverse roles in cancer cell biology and therapeutic promise
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and proliferation in cells was apparent at early stages of...
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Enhancing mass spectrometry imaging accessibility using convolutional autoencoders for deriving hypoxia-associated peptides from tumors
Mass spectrometry imaging (MSI) allows to study cancer’s intratumoral heterogeneity through spatially-resolved peptides, metabolites and lipids. Yet,...
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Sequence-specific remodeling of a topologically complex RNP substrate by Spb4
DEAD-box ATPases are ubiquitous enzymes essential in all aspects of RNA biology. However, the limited in vitro catalytic activities described for...
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Cold-shock proteome of myoblasts reveals role of RBM3 in promotion of mitochondrial metabolism and myoblast differentiation
Adaptation to hypothermia is important for skeletal muscle cells under physiological stress and is used for therapeutic hypothermia (mild hypothermia...
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Genome-wide investigations reveal the population structure and selection signatures of Nigerian cattle adaptation in the sub-Saharan tropics
BackgroundCattle are considered to be the most desirable livestock by small scale farmers. In Africa, although comprehensive genomic studies have...
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Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion
RNA-binding proteins (RBPs) modulate alternative splicing outcomes to determine isoform expression and cellular survival. To identify RBPs that...
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Cell cycle regulation: p53-p21-RB signaling
The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor...
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A transcriptomic analysis of Nsmce1 overexpression in mouse hippocampal neuronal cell by RNA sequencing
Mouse Nsmce1 gene is the homolog of non-structural maintenance of chromosomes element 1 (NSE1) that is mainly involved in maintenance of genome...
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ArcRNAs and the formation of nuclear bodies
Long noncoding RNAs (lncRNAs) have long been collectively and passively defined as transcripts that do not encode proteins. However, extensive...
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mRNP Transport in Eukaryots: Transport of mRNP Particles in Cytoplasm
After synthesis and processing in the nucleus, mature mRNA penetrates through nuclear pores to cytoplasm. mRNP particles are formed in the nucleus...
