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Global Identification of RNA-Binding Proteins in Bacteria
RNA-binding proteins (RBPs) are at the heart of many biological processes and are therefore essential for cellular life. Following identification of...
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Chaperons Against Self-Association for Phase-Separating RNA-Binding Proteins
Droplets formed through liquid–liquid phase separation (LLPS) are fluid-like liquids, and this fluidity is based on weak and transient interactions...
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Validation of the Interaction Between Stress-Responsive LncRNAs and RNA-Binding Proteins In Vitro
Plant long non-coding RNAs (lncRNAs) have been implicated in many biological processes, including responses to abiotic stresses, yet their detailed...
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Survey of the binding preferences of RNA-binding proteins to RNA editing events
BackgroundAdenosine-to-inosine (A-to-I) editing is an important RNA posttranscriptional process related to a multitude of cellular and molecular...
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Spatiotemporal control of RNA metabolism and CRISPR–Cas functions using engineered photoswitchable RNA-binding proteins
RNA molecules perform various crucial roles in diverse cellular processes, from translating genetic information to decoding the genome, regulating...
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Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion
RNA-binding proteins (RBPs) modulate alternative splicing outcomes to determine isoform expression and cellular survival. To identify RBPs that...
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Barley AGO4 proteins show overlap** functionality with distinct small RNA-binding properties in heterologous complementation
Key messageBarley AGO4 proteins complement expressional changes of epigenetically regulated genes in Arabidopsis ago4-3 mutant and show a distinct...
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Interaction between lncRNAs and RNA-binding proteins (RBPs) influences DNA damage response in cancer chemoresistance
The DNA damage response (DDR) is a crucial cellular signaling pathway activated in response to DNA damage, including damage caused by chemotherapy....
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Cytological Approaches to Visualize Intracellular Dynamics of RNA-Binding Proteins at Active Genes in Drosophila
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a family of RNA-binding proteins that modulate multiple aspects of gene activity and RNA...
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Identification of Significant RNA-Binding Proteins in the Process of CD44 Splicing Using the Boosted Beta Regression Algorithm
AbstractThe expression of RNA-binding proteins and their interaction with the spliced pre-mRNA are the key factors in determining the final isoform...
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Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing
RNA-binding proteins (RBPs) regulate diverse cellular processes by dynamically interacting with RNA targets. However, effective methods to capture...
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Effect of RNA-binding proteins on osteogenic differentiation of bone marrow mesenchymal stem cells
Tissue regeneration mediated by mesenchymal stem cells (MSCs) is an ideal way to repair bone defects. RNA-binding proteins (RBPs) can affect cell...
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Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing
Alternative splicing is an important step in eukaryotic mRNA pre-processing which increases the complexity of gene expression programs, but is...
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RNA binding proteins are potential novel biomarkers of egg quality in yellow catfish
BackgroundEgg quality is a major concern in fish reproduction and development. An effective evaluation of egg quality prior to fertilization is...
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GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins
GCLiPP is a global RNA interactome capture method that detects RNA-binding protein (RBP) occupancy transcriptome-wide. GCLiPP maps RBP-occupied sites...
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RNA-Binding Protein-Mediated mRNA Deadenylation in Mammalian Cell Extracts
Removal of the poly(A) tail, or deadenylation, is a crucial step in destabilizing mRNAs in eukaryotes. In this chapter, we describe a cell-free...
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Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide...
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Roles of RNA-binding proteins in neurological disorders, COVID-19, and cancer
RNA-binding proteins (RBPs) have emerged as important players in multiple biological processes including transcription regulation, splicing, R-loop...
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Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing
Sequence-specific RNA-binding proteins (RBPs) play central roles in splicing decisions. Here, we describe a modular splicing architecture that...
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Tethered Function Assays to Elucidate the Role of RNA-Binding Proteins
The fate of each RNA molecule is strongly determined by RNA-binding proteins (RBPs) which accompany transcripts from its synthesis to its...