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Small interannual variability in the body mass of a seabird with high flight costs
Seabird parents during chick rearing is hypothesized to regulate body mass to reduce flight costs and invest energy in current reproduction. Alcids...
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Two species of seabirds foraged in contrasting marine habitats across the cold-water belt along the coast of northern Hokkaido in the southwestern Okhotsk Sea
To understand the environmental factors affecting the density of foraging seabirds across the cold-water belt in the southwestern Okhotsk Sea, we...
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Using Magnetic Tweezers to Unravel the Mechanism of the G-quadruplex Binding and Unwinding Activities of DHX36 Helicase
Single-molecule manipulation methods are useful techniques to probe the interactions of proteins and nucleic acid structures. Here, we describe the...
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Deletion of 184–188 Nucleotides of Human Telomerase RNA Does Not Affect the Telomerase Functioning
AbstractTelomerase is a ribonucleoprotein complex, the main components of which are telomerase RNA and reverse transcriptase. Previously, it was...
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G-quadruplex DNA: a novel target for drug design
G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a continuous guanine-rich DNA sequence. Emerging evidence in recent years...
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Targeting G-quadruplex motifs interferes with differentiation of adipose-derived mesenchymal stem cells
BackgroundG-quadruplex (G4) motifs are nucleic acid secondary structures observed in mammalian genomes and transcriptomes able to regulate various...
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Roles of RNA-binding proteins in neurological disorders, COVID-19, and cancer
RNA-binding proteins (RBPs) have emerged as important players in multiple biological processes including transcription regulation, splicing, R-loop...
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Transcriptome and degradome sequencing reveals changes in Populus × euramericana ‘Neva’ caused by its allelopathic response to p-hydroxybenzoic acid
Plant species produce different types of allelopathic chemicals in nature; however, little is known about the differential regulation of plant...
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G4-quadruplex-binding proteins: review and insights into selectivity
There are over 700,000 putative G4-quadruplexes (G4Qs) in the human genome, found largely in promoter regions, telomeres, and other regions of high...
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Phase Separation Orchestrates Cancer Signaling: Stress Granules as a Promising Target for Cancer Therapy
Liquid–liquid phase separation (LLPS) has recently emerged as a new fundamental mechanism for the eukaryotic cellular organization via the formation...
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Guanine Quadruplexes in Cell Nucleus Metabolism
AbstractCell metabolism depends, to a large extent, on correct regulation of gene expression. One of the mechanisms of regulation is the formation of...
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Control of satellite cell function in muscle regeneration and its disruption in ageing
Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. In homeostasis,...
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HnRNP F/H associate with hTERC and telomerase holoenzyme to modulate telomerase function and promote cell proliferation
Human telomerase RNA component hTERC comprises multiple motifs that contribute to hTERC biogenesis, holoenzyme activity, and enzyme recruitment to...
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A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation
G-quadruplex (G4) DNA and G4 DNA resolvase are involved in a variety of biological processes. To understand the biological function of G4 DNA...
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Heat Shock-Induced Transcriptional and Translational Arrest in Mammalian Cells
The heat shock response is a highly conserved cellular stress response pathway that protects cells against stress-induced damages. The heat shock...
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G-Quadruplex in DNA und RNA – Strukturen mit biologischer Funktion?
For many years it is known that nucleic acids containing runs of guanines can fold into four-stranded structures, G-quadruplexes, but often they were...
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RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs
BackgroundRNA secondary structures in the 5′-untranslated regions (5′-UTR) of mRNAs are key to the post-transcriptional regulation of gene...
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Biochemical Characterization of G4 Quadruplex Telomerase RNA Unwinding by the RNA Helicase RHAU
G4 quadruplexes are stable secondary structures prevalent in DNA and RNA that exhibit diverse regulatory functions. Herein, we describe an in vitro...
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Mouse Models of Erythropoiesis and Associated Diseases
Animal models of erythropoiesis have been, and will continue to be, important tools for understanding molecular mechanisms underlying the development...
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Pitching stability of diving seabirds during underwater locomotion: a comparison among alcids and a penguin
BackgroundIn animals, recoil motion resulting from underwater propulsion can destabilise trajectory and decrease locomotory performance. The posture...
