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Function and regulation of RGS family members in solid tumours: a comprehensive review
G protein-coupled receptors (GPCRs) play a key role in regulating the homeostasis of the internal environment and are closely associated with tumour...
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KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination
BackgroundKRAS- mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS -G12C selective...
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Genome-wide selection signatures detection in Shanghai Holstein cattle population identified genes related to adaption, health and reproduction traits
BackgroundOver several decades, a wide range of natural and artificial selection events in response to subtropical environments, intensive pasture...
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RGS6 suppresses TGF-β-induced epithelial–mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4
Regulator of G-protein signaling 6 (RGS6) is a newly discovered tumor suppressor that has been shown to be protective in development of various...
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Residue-level determinants of RGS R4 subfamily GAP activity and specificity towards the Gi subfamily
The structural basis for the GTPase-accelerating activity of regulators of G protein signaling (RGS) proteins, as well as the mechanistic basis for...
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Slc43a2+ T cell metastasis from spleen to brain in RGNNV infected teleost
The origin of T cells in the teleost’s brain is unclear. While viewing the central nervous system (CNS) as immune privileged has been widely...
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RGS5–TGFβ–Smad2/3 axis switches pro- to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth
Regulator-of-G-protein-signaling-5 (RGS5), a pro-apoptotic/anti-proliferative protein, is a signature molecule of tumor-associated pericytes, highly...
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Genome-wide DNA methylation analysis in Chinese Chenghua and Yorkshire pigs
BackgroundThe Chinese Chenghua pig (CHP) is a typical Chinese domestic fatty pig breed with superior meat quality characteristics, while the...
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Comparative transcriptomic analysis revealed dynamic changes of distinct classes of genes during development of the Manila clam (Ruditapes philippinarum)
BackgroundThe Manila clam Ruditapesphilippinarum is one of the most economically important marine shellfish. However, the molecular mechanisms of...
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The swan genome and transcriptome, it is not all black and white
BackgroundThe Australian black swan ( Cygnus atratus ) is an iconic species with contrasting plumage to that of the closely related northern...
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A composite strategy of genome-wide association study and copy number variation analysis for carcass traits in a Duroc pig population
BackgroundCarcass traits are important in pig breeding programs for improving pork production. Understanding the genetic variants underlies complex...
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Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs
When neonatal pigs continuously fed formula are supplemented with leucine pulses, muscle protein synthesis and body weight gain are enhanced. To...
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Genome-wide associations for immune traits in two maternal pig lines
BackgroundIn recent years, animal welfare and health has become more and more important in pig breeding. So far, numerous parameters have been...
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Investigating the characteristics of genes and variants associated with self-reported hearing difficulty in older adults in the UK Biobank
BackgroundAge-related hearing loss is a common, heterogeneous disease with a strong genetic component. More than 100 loci have been reported to be...
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A meta-analysis of genome-wide association studies for average daily gain and lean meat percentage in two Duroc pig populations
BackgroundAverage daily gain (ADG) and lean meat percentage (LMP) are the main production performance indicators of pigs. Nevertheless, the genetic...
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A consensus multi-view multi-objective gene selection approach for improved sample classification
BackgroundIn the field of computational biology, analyzing complex data helps to extract relevant biological information. Sample classification of...
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Daily rhythms in gene expression of the human parasite Schistosoma mansoni
BackgroundThe consequences of the earth’s daily rotation have led to 24-h biological rhythms in most organisms. Even some parasites are known to have...
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Essential roles of EphrinB2 in mammalian heart: from development to diseases
EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular...
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Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation
BackgroundHuman induced pluripotent stem cells (iPSC) have opened new avenues for regenerative medicine. Consequently, iPSC-derived motor neurons...
