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A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy
Physiological rapid eye movement (REM) sleep termination is vital for initiating non-REM (NREM) sleep or arousal, whereas the suppression of...
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Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice
In the adult sensory cortex, increases in neural activity elicited by sensory stimulation usually drive vasodilation mediated by neurovascular...
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Effect of 60 days of head down tilt bed rest on amplitude and phase of rhythms in physiology and sleep in men
Twenty-four-hour rhythms in physiology and behaviour are shaped by circadian clocks, environmental rhythms, and feedback of behavioural rhythms onto...
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Tick-borne encephalitis affects sleep–wake behavior and locomotion in infant rats
Background/AimsTick-borne encephalitis (TBE) is a disease affecting the central nervous system. Over the last decade, the incidence of TBE has...
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Aspects of tree shrew consolidated sleep structure resemble human sleep
Understanding human sleep requires appropriate animal models. Sleep has been extensively studied in rodents, although rodent sleep differs...
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Motor Activity and “Neotenic” Sleep in the Naked Mole Rat (Heterocephalus glaber) under Isolation
AbstractFor the first time, continuous registration of motor activity and electroencephalogram for 40 days was carried out in four individuals of the...
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Towards organism-level systems biology by next-generation genetics and whole-organ cell profiling
The system-level identification and analysis of molecular and cellular networks in mammals can be accelerated by “next-generation” genetics, which is...
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Comparison of the Effect of the Antidepressants Imipramine and Fluoxetine on the Sleep–Wake Cycle and Characteristics of Sleep Spindles in Wag/Rij Rats with Absence Epilepsy and Comorbid Depression
AbstractWAG/Rij rats are a valid model of absence epilepsy and comorbid depression. We have previously shown that WAG/Rij rats have disturbances in...
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Hypothalamic supramammillary neurons that project to the medial septum modulate wakefulness in mice
The hypothalamic supramammillary nucleus (SuM) plays a crucial role in controlling wakefulness, but the downstream target regions participating in...
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BNST GABAergic neurons modulate wakefulness over sleep and anesthesia
The neural circuits underlying sleep-wakefulness and general anesthesia have not been fully investigated. The GABAergic neurons in the bed nucleus of...
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An update on recent advances in targeted memory reactivation during sleep
Targeted Memory Reactivation (TMR) is a noninvasive tool to manipulate memory consolidation during sleep. TMR builds on the brain’s natural processes...
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Seasonal variation in sleep time: jackdaws sleep when it is dark, but do they really need it?
Sleep is an important behavioural and physiological state that is ubiquitous throughout the animal kingdom. Birds are an interesting group to study...
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α-Synuclein reduces acetylserotonin O-methyltransferase mediated melatonin biosynthesis by microtubule-associated protein 1 light chain 3 beta-related degradation pathway
Previous studies have demonstrated that α-synuclein (α-SYN) is closely associated with rapid eye movement sleep behavior disorder (RBD) related to...
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Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity
Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is generally thought to be involved. Here we show multiple...
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Auditory stimulation during REM sleep modulates REM electrophysiology and cognitive performance
REM sleep is critical for memory, emotion, and cognition. Manipulating brain activity during REM could improve our understanding of its function and...
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A prolonged stress rat model recapitulates some PTSD-like changes in sleep and neuronal connectivity
Chronic post-traumatic stress disorder (PTSD) exhibits psychological abnormalities during fear memory processing in rodent models. To simulate...
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Maternal Methyl-Enriched Diet Normalizes Characteristics of the Sleep–Wake Cycle and Sleep Spindles in Adult Offspring of WAG/Rij Rats with Genetic Absence Epilepsy
AbstractAs we have shown previously, a perinatal maternal methyl-enriched diet (MED) reduces the number of spike-and-wave discharges (SWDs) and...
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Sleep-associated insulin resistance promotes neurodegeneration
Lifestyle modification can lead to numerous health issues closely associated with sleep. Sleep deprivation and disturbances significantly affect...
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Understanding zebrafish sleep and wakefulness physiology as an experimental model for biomedical research
Sleep is a globally observable fact, or period of reversible distracted rest, that can be distinguished from arousal by various behavioral criteria....
