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Improving tyrosol production efficiency through shortening the allosteric signal transmission distance of pyruvate decarboxylase
AbstractTyrosol is an important chemical in medicine and chemical industries, which can be synthesized by a four-enzyme cascade pathway constructed...
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Process optimization for biosynthesis of pyruvate decarboxylase (PDC) and Neuberg’s ketol (PAC) from a novel Pichia cecembensis through response surface methodology
PurposePhenylacetylcarbinol (PAC) is an intermediate for the synthesis of several active pharmaceutical ingredients (ephedrine, pseudoephedrine,...
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Engineering Clostridium acetobutylicum for Enhanced Solvent Production by Overexpression of Pyruvate Decarboxylase from Zymomonas mobilis
AbstractClostridium acetobutylicum DSM 792 has been characterized as a native acetone-butanol-ethanol (ABE) fermenting bacterium. C. acetobutylicm ...
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Optimization of Aerobic Synthesis of Succinic Acid from Glucose by Recombinant Escherichia coli Strains through the Tricarboxylic Acid Cycle Variant Mediated by the Action of 2-Ketoglutarate Decarboxylase
The biosynthesis of succinic acid from glucose by the previously engineered E. coli strain SUC1.0 (pMW119- kgd ) (MG1655 ∆ ackA-pta , ∆ poxB , ∆ ldhA , ∆ adhE ,...
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Metabolic evidence for distinct pyruvate pools inside plant mitochondria
The majority of the pyruvate inside plant mitochondria is either transported into the matrix from the cytosol via the mitochondria pyruvate carrier...
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The effect of externally supplied pyruvate on the IDH enzyme of the cyanobacterium Nostoc muscorum Meg 1 directly reflects on its photosynthetic performance and diazotrophy
Pyruvate, the end product of glycolysis, is an important metabolite for the tricarboxylic acid (TCA) cycle and lipid metabolism. Pyruvate is...
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Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis
In human metabolism, pyruvate dehydrogenase complex (PDC) is one of the most intricate and large multimeric protein systems representing a central...
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Research progress of l-aspartate-α-decarboxylase and its isoenzyme in the β-alanine synthesis
Driven by the massive demand in recent years, the production of β-alanine has significantly progressed in chemical and biological ways. Although the...
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The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
The enzyme arginase 1 (A1) hydrolyzes the amino acid arginine to form L-ornithine and urea. Ornithine is further converted to polyamines by the...
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Submergence response of pyruvate decarboxylase family genes in adzuki bean
Pyruvate decarboxylase (PDC) is the main enzyme in ethanol fermentation in plant low-oxygen response. Expression of the PDC gene can be induced by...
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Identification of key residues for the activity of aspartate 4-decarboxylase towards l-3-methylaspartate
Aspartate 4-decarboxylase (ASD) has been modified to obtain the catalytic ability of the unnatural substrate l -3-methylaspartate. However, the...
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Metabolic engineering of Corynebacterium glutamicum for the efficient production of β-Alanine from glucose
β-Alanine is the only naturally occurring β-type amino acid, with various applications in the pharmaceutical, food, and chemical industries. Given...
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Histological, physio-biochemical, and transcriptomic analyses reveal the potential limiting factors for successful grafting of pecan
Budding is an important grafting technique to asexually propagate pecan ( Carya illinoinensis (Wangenh.) K. Koch). To determine factors that might...
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Integrated metabolomic and transcriptomic strategies to reveal alkali-resistance mechanisms in wild soybean during post-germination growth stage
Main conclusionThe keys to alkali-stress resistance of barren-tolerant wild soybean lay in enhanced reutilization of reserves in cotyledons as well...
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Changes in terpene biosynthesis and submergence tolerance in cotton
BackgroundFlooding is among the most severe abiotic stresses in plant growth and development. The mechanism of submergence tolerance of cotton in...
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Blocking the 2,3-butanediol synthesis pathway of Klebsiella pneumoniae resulted in l-valine production
Klebsiella pneumoniae is a 2,3-butanediol producing bacterium. Nevertheless, a design and construction of l -valine production strain was studied in...
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Genome engineering of Kluyveromyces marxianus for high D-( −)-lactic acid production under low pH conditions
AbstractSaccharomyces cerevisiae is the workhorse of fermentation industry. Upon engineering for D-lactate production by a series of gene deletions,...
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Core Transcriptome of Hydrogen Producing Marine Vibrios Reveals Contribution of Glycolysis in Their Efficient Hydrogen Production
Pyruvate (Pyr) is the end product of the glycolysis pathway. Pyr is also renewable and is further metabolized to produce formate, which is the...
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In Silico Prediction of Metabolic Fluxes in Cancer Cells with Altered S-adenosylmethionine Decarboxylase Activity
This paper investigates the redistribution of metabolic fluxes in the cell with altered activity of S-adenosylmethionine decarboxylase (SAMdc, EC:...
