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Pyridoxamine protects human granulosa cells against advanced glycation end-products-induced steroidogenesis disturbances
BackgroundOvarian advanced glycation end-products (AGEs) accumulation is associated with ovarian granulosa cells (GCs) dysfunction. Vitamin B6...
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Combined strategy employing MutMap and RNA-seq reveals genomic regions and genes associated with complete panicle exsertion in rice
Complete panicle exsertion (CPE) in rice is an important determinant of yield and a desirable trait in breeding. However, the genetic basis of CPE in...
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Multiple forms of vitamin B6 regulate salt tolerance by balancing ROS and abscisic acid levels in maize root
Salt stress causes osmotic stress, ion toxicity and oxidative stress, inducing the accumulation of abscisic acid (ABA) and excessive reactive oxygen...
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Underground metabolism facilitates the evolution of novel pathways for vitamin B6 biosynthesis
AbstractThe term vitamin B6 is a designation for the vitamers pyridoxal, pyridoxamine, pyridoxine and the respective phosphate esters...
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Mechanism of D-Cycloserine Inhibition of D-Amino Acid Transaminase from Haliscomenobacter hydrossis
AbstractD-cycloserine inhibits pyridoxal-5′-phosphate (PLP)-dependent enzymes. Inhibition effect depend on organization of the active site and...
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Metabolomics reveals high fructose-1,6-bisphosphate from fluoride-resistant Streptococcus mutans
BackgroundFluoride-resistant Streptococcus mutans ( S. mutans ) strains have developed due to the wide use of fluoride in dental caries prevention....
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Develo** Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models
AbstractHigh prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring...
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Current Trends in the Biosynthesis of Vitamins
Vitamins are substances that are consumed through the diet because humans are unable to synthesize them. They play a vital role in the well-being and...
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Supplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats
AbstractGut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the...
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Serum metabolomics study of narcolepsy type 1 based on ultra-performance liquid chromatography–tandem mass spectrometry
Narcolepsy is a chronic and underrecognized sleep disorder characterized by excessive daytime sleepiness and cataplexy. Furthermore, narcolepsy type...
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An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and inhibition
The formation of a heterogeneous set of advanced glycation end products (AGEs) is the final outcome of a non-enzymatic process that occurs in vivo on...
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Enrichment of Ciliates and Flagellates
Ciliates and flagellates are the group of protozoans, found abundant in agricultural and forest soil, as well as in freshwater, coastal, and marine...
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Intestinal Microbiomics and Metabolomics Insights into the Hepatoprotective Effects of Lactobacillus paracasei CCFM1222 Against the Acute Liver Injury in Mice
In recent years, acute liver injury (ALI) has received wide-range attention in the world due to its relatively high morbidity and mortality. This...
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Enzymatic and Non-enzymatic Detoxification of Reactive Carbonyl Compounds Improves the Oxidative Stress Tolerance in Cucumber, Tobacco and Rice Seedlings
Detoxification of reactive carbonyl compounds (RCC) is crucial to sustain cellular activity to improve plant growth and development. Seedling growth...
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Plasma methionine metabolic profile is associated with longevity in mammals
Methionine metabolism arises as a key target to elucidate the molecular adaptations underlying animal longevity due to the negative association...
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Metabolic Engineering of Wheat for Enhanced Vitamin B6 to Combat Hidden Hunger
Vitamin B6 is an essential micronutrient for humans which is synthesized in plants via de novo pathway. Since this pathway involves only two enzymes,...
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Probiotics alleviate constipation and inflammation in late gestating and lactating sows
Constipation and systemic inflammation are common in late pregnant and lactating sows, which cause health problems like uteritis, mastitis, dystocia,...
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Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma
BackgroundCuproptosis is a new type of copper-induced cell death that is characterized by the aggregation of lipoylated tricarboxylic acid (TCA)...
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Metabolic and physiological adaptations of microalgal growth-promoting bacterium Azospirillum brasilense growing under biogas atmosphere: a microarray-based transcriptome analysis
Using microalgal growth-promoting bacteria (MGPB) to improve the cultured microalga metabolism during biotechnological processes is one of the most...
