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Anticancer potential and structure activity studies of purine and pyrimidine derivatives: an updated review
Cancer is the world’s leading cause of death impacting millions of lives globally. The increasing research over the past several decades has focused...
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Synthesis of 6-Alkylamino-2-alkylthio(alkoxy) Purine Derivatives: Antiplatelet Aggregation Activity Evaluation and 3D-QSAR Analysis
AbstractGlobally, cardio-cerebrovascular diseases caused by platelet aggregation pose a grave threat to human health, and hence, research on...
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Design and investigation of interactions of novel peptide conjugates of purine and pyrimidine derivatives with EGFR and its mutant T790M/L858R: an in silico and laboratory study
Peptide-based therapeutics have been gaining attention due to their ability to actively target tumor cells. Additionally, several varieties of...
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Effects of low-quality forage and starter protein content in starter diet of young calves on growth performance, rumen fermentation, and urinary purine derivatives
Feeding low-quality forage (LQF) has been evaluated in mature ruminants and results show that it has been improved nitrogen utilization efficiency....
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Revisiting biocrystallization: purine crystalline inclusions are widespread in eukaryotes
Despite the widespread occurrence of intracellular crystalline inclusions in unicellular eukaryotes, scant attention has been paid to their...
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Supplementation of n-3 fatty acid and ruminal undegradable to degradable protein ratio in young lambs raised under heat condition: effects on growth performance and urinary purine derivatives
AbstractThe present study evaluated the effect of supplementation alpha-linolenic fatty acid source (ALA) with different rumen undegradable to...
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6-Pyrazolylpurine and its deaza derivatives as nucleobases for silver(I)-mediated base pairing with pyrimidines
The artificial nucleobase 6-pyrazolylpurine (6PP) and its deaza derivatives 1-deaza-6-pyrazolylpurine ( 1D 6PP), 7-deaza-6-pyrazolylpurine ( 7D 6PP), and...
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Study of Multiple Enzymatic Incorporation of Modified Nucleotides of Purine and Pyrimidine Nature in the Growing DNA Chain
AbstractThe substrate properties of nitrogen-base modified derivatives of purine and pyrimidine deoxynucleoside triphosphates during their...
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Identification of a transcription factor, PunR, that regulates the purine and purine nucleoside transporter punC in E. coli
Many genes in bacterial genomes are of unknown function, often referred to as y-genes. Recently, the analytic methods have divided bacterial...
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Synthesis, Biological Screening, and Molecular Dockingof Drug Carrier Maleimide Derivatives
AbstractObjective: New maleimide-drug derivatives ( Ia–Ic ) were synthesized and tested for their anticancer activity against MCF-7 cell line, and...
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Metabolites involved in purine degradation, insulin resistance, and fatty acid oxidation are associated with prediction of Gestational diabetes in plasma
IntroductionGestational diabetes mellitus (GDM) significantly increases maternal and fetal health risks, but factors predictive of GDM are poorly...
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Synthesis of Fluorine-Containing Analogues of Purine Deoxynucleosides: Optimization of Enzymatic Transglycosylation Conditions
AbstractIn this work, a comparative analysis of the conditions of transglycosylation reactions catalyzed by E. coli nucleoside phosphorylases was...
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Rewiring of purine metabolism in response to acidosis stress in glioma stem cells
Glioma stem cells (GSCs) contribute to therapy resistance and poor outcomes for glioma patients. A significant feature of GSCs is their ability to...
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Migraine signaling pathways: purine metabolites that regulate migraine and predispose migraineurs to headache
Migraine is a debilitating disorder that afflicts over 1 billion people worldwide, involving attacks that result in a throbbing and pulsating...
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Synthesis, Structure, and In Vitro Pharmacological Evaluation of some New Pyrimidine-2-Sulfonamide Derivatives and Their Molecular Docking Studies on Human Estrogen Receptor Alpha and CDK2/Cyclin Proteins
AbstractIn this approach, novel pyrimidine-2-sulfonamide derivatives based on the 2 H -chromen-2-one moiety were synthesized and evaluated as...
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Acetylcholine Inhibitory Study of Novel Thio Linked Coumarin-Benzimidazole Derivatives: Design, Synthesis, Computational, and In Silico Molecular Docking Studies
AbstractObjective: This article focused on the synthesis and characterization of heterocyclic compounds containing two heteroatoms, as well as...
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Natural Guanine Derivatives Exert PARP-Inhibitory and Cytoprotective Effects in a Model of Cardiomyocyte Damage under Oxidative Stress
AbstractInhibitors of human poly(ADP-ribose) polymerase (PARP) are considered as promising agents for treatment of cardiovascular, neurological, and...
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Functional groups matter: metabolomics analysis of Escherichia coli exposed to trans-cinnamic acid and its derivatives unveils common and unique targets
Phenolic acids are derivatives of benzoic and cinnamic acids, which possess important biological activities at certain concentrations. Trans-cinnamic...
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Synthesis of 1,2,3-Triazole Analogs of Linagliptin as Novel DPP-4 Inhibitors: DFT, Molecular Docking Approach
AbstractThe synthesis of some novel 1,2,3-triazole-based linagliptin derivatives from the CuI catalyzed 1,3-dipolar cycloaddition reaction between N -...
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Novel N-α-amino acid spacer-conjugated phthalimide–triazine derivatives: synthesis, antimicrobial and molecular docking studies
To design and develop novel antimicrobial agents, a series of phthalimide–triazine-based derivatives ( 6a–6e ) were synthesized, characterized and...
