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Nonviral genome engineering of natural killer cells
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of immune surveillance. Given their ability to rapidly and...
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Affinity Maturation of the Natural Ligand (B7-H6) for Natural Cytotoxicity Receptor NKp30 by Yeast Surface Display
In recent years, the development of bispecific antibodies (bsAbs) has experienced tremendous progress for disease treatment, and consequently, a...
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Occurrence of D-amino acids in natural products
Since the identified standard genetic code contains 61 triplet codons of three bases for the 20 L-proteinogenic amino acids (AAs), no D-AA should be...
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Pectin: Health-promoting properties as a natural galectin-3 inhibitor
Galectin-3 has a variety of important pathophysiological significance in the human body. Much evidence shows that the abnormal expression of...
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Routes of Stem Cell Administration
Stem cells are very promising for the treatment of a plethora of human diseases. Numerous clinical studies have been conducted to assess the safety...
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MicroRNA profiling of royal jelly extracellular vesicles and their potential role in cell viability and reversing cell apoptosis
MiRNAs are small non-coding RNA molecules that play important regulatory roles in diverse biological processes. Royal jelly, a milky-white substance...
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Stem Cell Production: Processes, Practices, and Regulation
The latest scientific advances in the field of cell and molecular biology allowed the development of a new category of therapies, based on the cells...
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Exosomes derived from programmed cell death: mechanism and biological significance
Exosomes are nanoscale extracellular vesicles present in bodily fluids that mediate intercellular communication by transferring bioactive molecules,...
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Computational Analysis of Single-Cell RNA-Seq Data
Single-cell RNAseq data can be generated using various technologies, spanning from isolation of cells by FACS sorting or droplet sequencing, to the...
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Preparation of single-cell suspensions of mouse glomeruli for high-throughput analysis
The kidney glomerulus is essential for proper kidney function. Until recently, technical challenges associated with glomerular isolation and...
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IL-33 promotes double negative T cell survival via the NF-κB pathway
IL-33, which is a crucial modulator of adaptive immune responses far beyond type 2 response, can enhance the function of several T cell subsets and...
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The YAP–TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress
Sublethal cell damage can trigger senescence, a complex adaptive program characterized by growth arrest, resistance to apoptosis and a...
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Role of Dead Cells in Collective Stress Tolerance in Microbial Communities: Evidence from Yeast
AbstractA substantial part of yeast life cycle takes place in the communities where the cells are surrounded by their own clones. Meanwhile, yeast...
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Liquid biopsy on the horizon in immunotherapy of non-small cell lung cancer: current status, challenges, and perspectives
Non-small cell lung cancer (NSCLC) is one of the most threatening malignancies to human health and life. In most cases, patients with NSCLC are...
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Natural display of nuclear-encoded RNA on the cell surface and its impact on cell interaction
BackgroundCompared to proteins, glycans, and lipids, much less is known about RNAs on the cell surface. We develop a series of technologies to test...
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Isolation of Hepatic Stellate Cells and Lymphocytes for Co-culture Systems
In contrast to quiescent hepatic stellate cells (HSCs), activated HSCs play crucial roles in the development of liver fibrosis by producing a huge...
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PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis
Phosphatase and tensin homologue (PTEN) is frequently mutated in human cancer, but its roles in lymphopoiesis and tissue homeostasis remain poorly...
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Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity
Chemokines such as C-C motif ligand 5 (CCL5) regulate immune cell trafficking in the tumor microenvironment (TME) and govern tumor development,...
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The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2
The obligate intracellular parasite Toxoplasma gondii causes life-threatening toxoplasmosis to immunocompromised individuals. The pathogenesis of Toxoplasma...
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Recent highlights in the immunomodulatory aspects of Treg cell-derived extracellular vesicles: special emphasis on autoimmune diseases and transplantation
In order to maintain immunological tolerance to self and non-self antigens, one’s T regulatory (Treg) cells play a critical role in the regulation of...
