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Protrudin-mediated ER-endosome contact sites promote phagocytosis
During phagocytosis, endosomes both contribute with membrane to forming phagosomes and promote phagosome maturation. However, how these vesicles are...
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Protrudin regulates FAK activation, endothelial cell migration and angiogenesis
During angiogenesis, endothelial cells form protrusive sprouts and migrate towards the angiogenic stimulus. In this study, we investigate the role of...
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Protrudin modulates seizure activity through GABAA receptor regulation
Epilepsy is a serious neurological disease characterized by recurrent unprovoked seizures. The exact etiology of epilepsy is not fully understood....
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ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic
Mutations in the gene encoding the microtubule severing ATPase spastin are the most frequent cause of hereditary spastic paraplegia, a genetic...
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Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model
Lysosomes orchestrate degradation and recycling of exogenous and endogenous material thus controlling cellular homeostasis. Little is known how this...
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To be or not to be a fat burner, that is the question for cpt1c in cancer cells
There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis, prognosis, and treatment of different tumor types. Described...
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ERnet: a tool for the semantic segmentation and quantitative analysis of endoplasmic reticulum topology
The ability to quantify structural changes of the endoplasmic reticulum (ER) is crucial for understanding the structure and function of this...
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Stay in touch with the endoplasmic reticulum
The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and sheets, forms the most widely distributed membrane system in...
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Phosphoinositides as membrane organizers
Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous phospholipid in the cytoplasmic leaflet of eukaryotic...
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Mechanisms and roles of podosomes and invadopodia
Cell invasion into the surrounding extracellular matrix or across tissue boundaries and endothelial barriers occurs in both physiological and...
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Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila
The difficulties of injured and degenerated neurons to regenerate neurites and regain functions are more significant than in other body tissues,...
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The role of lysosomes in cancer development and progression
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular...
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MYO1H is a novel candidate gene for autosomal dominant pure hereditary spastic paraplegia
In this study, we aimed to determine the genetic basis of a Turkish family related to hereditary spastic paraplegia (HSP) by exome sequencing. HSP is...
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The Role of Rab GTPases in the development of genetic and malignant diseases
Small GTPases have been shown to play an important role in several cellular functions, including cytoskeletal remodeling, cell polarity,...
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Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
BackgroundThe endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic terminal, to move...
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Protein dynamics at invadopodia control invasion–migration transitions in melanoma cells
Cell invasion is a highly complex process that requires the coordination of cell migration and degradation of the extracellular matrix. In melanoma...
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Surface cholesterol-enriched domains specifically promote invasion of breast cancer cell lines by controlling invadopodia and extracellular matrix degradation
Tumor cells exhibit altered cholesterol content. However, cholesterol structural subcellular distribution and implication in cancer cell invasion are...
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Regulation of axonal regeneration after mammalian spinal cord injury
One hundred years ago, Ramón y Cajal, considered by many as the founder of modern neuroscience, stated that neurons of the adult central nervous...
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Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells
Cholesterol accumulation in late endosomes is a prevailing phenotype of Niemann-Pick type C1 (NPC1) mutant cells. Likewise, annexin A6 (AnxA6)...
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Lysosomes as dynamic regulators of cell and organismal homeostasis
Exciting new discoveries have transformed the view of the lysosome from a static organelle dedicated to the disposal and recycling of cellular waste...
