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The acetyltransferase BmCBP changes the acetylation modification of BmSP3 and affects its protein expression in silkworm, Bombyx mori
BackgroundProtein acetylation is an important post-translational modification (PTM) that widely exists in organisms. As a reversible PTM, acetylation...
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Lysine acetylation of histone acetyltransferase adaptor protein ADA2 is a mechanism of metabolic control of chromatin modification in plants
Histone acetylation is a predominant active chromatin mark deposited by histone acetyltransferases (HATs) that transfer the acetyl group from acetyl...
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Histone acetyltransferase Kat2a regulates ferroptosis via enhancing Tfrc and Hmox1 expression in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a prevalent myocardial microvascular complication of the myocardium with a complex pathogenesis. Investigating the...
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EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
The androgen receptor (AR) is a primary target for treating prostate cancer (PCa), forming the bedrock of its clinical management. Despite their...
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The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases
The acetylation of α-tubulin on lysine 40 is a well-studied post-translational modification which has been associated with the presence of long-lived...
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N(alpha)-acetyltransferase 40-mediated histone acetylation plays an important role in ecdysone regulation of metamorphosis in the red flour beetle, Tribolium castaneum
Histone acetylation, a crucial epigenetic modification, is governed by histone acetyltransferases (HATs), that regulate many biological processes....
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Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors
Bacterial polyynes are highly active natural products with a broad spectrum of antimicrobial activities. However, their detailed mechanism of action...
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Lercanidipine ameliorated doxorubicin-induced neuroinflammation and maintained the expressions of choline acetyltransferase via enhancing the levels of PI3K/AKT/HIF1-α expressions
BackgroundDoxorubicin (DOX) may cause various neurological side effects in the brain. Lercanidipine (LRD) has antioxidant, anti-inflammatory, and...
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Arylalkylamine N-acetyltransferase activity parallel to work types and their temporal shift suggests its involvement in polyethism regulation in Apis mellifera workers
Arylalkylamine N -acetyltransferase (AANAT) is a large family of enzymes that catalyze the acetyl-CoA-dependent acetylation of an amine or...
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Crystal structure of the phage-encoded N-acetyltransferase in complex with acetyl-CoA, revealing a novel dimeric arrangement
Bacteriophages employ diverse mechanisms to facilitate the proliferation of bacteriophages. The Salmonella -infecting phage SPN3US contains a putative...
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The SAGA histone acetyltransferase module targets SMC5/6 to specific genes
BackgroundStructural Maintenance of Chromosomes (SMC) complexes are molecular machines driving chromatin organization at higher levels. In...
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N-acetyltransferase 10 promotes cutaneous wound repair via the NF-κB-IL-6 axis
Cutaneous wound healing, an integral part for protection of skin barrier, is a complex biological process and intimately associated with keratinocyte...
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Conserved and plant-specific histone acetyltransferase complexes cooperate to regulate gene transcription and plant development
Although a conserved SAGA complex containing the histone acetyltransferase GCN5 is known to mediate histone acetylation and transcriptional...
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Regioselective O-acetylation of various glucosides catalyzed by Escherichia coli maltose O-acetyltransferase
AbstractEscherichia coli , a well-known prokaryotic organism, has been widely employed as a versatile host for heterologous overexpression of...
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In vitro post-ovulatory oocyte ageing in grass carp Ctenopharyngodon idella affects H4K12 acetylation pattern and histone acetyltransferase activity
Delayed fertilization leads to the ageing of post-ovulatory oocytes and reduces the developmental competence of arising embryos. Little information...
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Exploring the Composition and Catalytic Specificity of Sorghum Histone Acetyltransferase Complexes
Histone acetylation plays important roles in gene regulation and is catalyzed by histone acetyltransferases (HATs). The performance of histone...
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N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, manifests as accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular...
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Identification of critical residues of O-antigen-modifying O-acetyltransferase B (OacB) of Shigella flexneri
BackgroundShigellosis is an acute gastrointestinal disease caused primarily by the bacterium Shigella flexneri . Upon ingestion, S. flexneri ...
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Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage
BackgroundN-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been...
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Genome-wide identification, phylogenetic classification of histone acetyltransferase genes, and their expression analysis in sugar beet (Beta vulgaris L.) under salt stress
Main conclusionThis study identified seven histone acetyltransferase-encoding genes ( HAT s) from Beta vulgaris L. (sugar beet) genome through...
