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Decellularized Prostate for Cancer Studies
AbstractRegenerative medicine researchers are interested in extracellular matrix (ECM) investigations around fabricating scaffolds that mimic the...
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The “Ins and Outs” of Prostate Specific Membrane Antigen (PSMA) as Specific Target in Prostate Cancer Therapy
Prostate-specific membrane antigen (PSMA)PSMA is expressed in epithelial cells of the prostate gland and is strongly upregulated in prostatic...
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UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells
BackgroundUbiquitin-conjugating enzyme E2 N (UBE2N) is recognized in the progression of some cancers; however, little research has been conducted to...
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Identification of the mitochondrial protein POLRMT as a potential therapeutic target of prostate cancer
RNA polymerase mitochondria (POLRMT) is essential for mitochondrial transcription machinery and other mitochondrial functions. Its expression and...
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Interaction of pRb and β-Catenin in Cancer and Normal Human Prostate Tissue
AbstractProstate cancer (PCa) is one of the most common oncological diseases, which passes through two stages in its development: localized PCa and...
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Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer
The human microbiome has been proposed as a potentially useful biomarker for several cancers. To examine this, we made use of salivary samples from...
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A novel circular RNA, circMAML3, promotes tumor progression of prostate cancer by regulating miR-665/MAPK8IP2 axis
Many studies have now demonstrated that circRNAs are aberrantly expressed in cancer and are involved in the regulation of malignant tumor...
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Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer
Tumor expression of prostate-specific membrane antigen (PSMA) is lost in 15–20% of men with castration-resistant prostate cancer (CRPC), yet the...
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Metformin-induced oxidative stress inhibits LNCaP prostate cancer cell survival
BackgroundPreclinical and clinical studies over the past several decades have indicated the potential value of metformin, a widely utilized treatment...
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Knockdown of KIF15 suppresses proliferation of prostate cancer cells and induces apoptosis through PI3K/Akt signaling pathway
Prostate cancer is one of the most common malignancies in men, which has been considered a public health threat. KIF15 is a kind of driver protein,...
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DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2
Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of castration-resistant prostate cancer resistant to androgen receptor...
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Multiregion sampling of de novo metastatic prostate cancer reveals complex polyclonality and augments clinical genoty**
De novo metastatic prostate cancer is highly aggressive, but the paucity of routinely collected tissue has hindered genomic stratification and...
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The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
BackgroundProstate cancer is a leading cause of cancer-related deaths among men worldwide. Docetaxel chemotherapy has proven effective in improving...
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Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironment
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial...
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Proteomics of prostate cancer serum and plasma using low and high throughput approaches
Despite progress, MS-based proteomics in biofluids, especially blood, faces challenges such as dynamic range and throughput limitations in biomarker...
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Proteomic profiling of prostate cancer reveals molecular signatures under antiandrogen treatment
BackgroundTumorigenesis and progression of prostate cancer (PCa) are indispensably dependent on androgen receptor (AR). Antiandrogen treatment is the...
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TP63–TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer
BackgroundProstate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methylation and a high...
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ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer
Immune checkpoint blockade has yet to produce robust anti-cancer responses for prostate cancer. Sialyltransferases have been shown across several...
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A new gold(I) phosphine complex induces apoptosis in prostate cancer cells by increasing reactive oxygen species
Thioredoxin reductase (TrxR) is a pivotal regulator of redox homeostasis. It is frequently overexpressed in various cancer cells, including prostate...
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Examining the Effect of PARP-1 Inhibitors on Transcriptional Activity of Androgen Receptor in Prostate Cancer Cells
Since the early 1940s, androgen ablation has been the cornerstone of treatment for prostate cancer (PC). Importantly, androgen receptor (AR)...