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PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter
Polycomb group RING finger protein 6 (PCGF6) plays an important role as a regulator of transcription in a variety of cellular processes, including...
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Exploring diet-induced promoter hypomethylation and PDK4 overexpression: implications for type 2 diabetes mellitus
BackgroundType 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by limited metabolic flexibility in the body. Such limitation...
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Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis
BackgroundCancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for...
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Promoter hypomethylation as potential confounder of Ras gene overexpression and their clinical significance in subsets of urothelial carcinoma of bladder
Overexpression of normal Ras and its aberrant CpG island methylation in the promoter regions have been shown to direct cells for uncontrolled...
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Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma
Programmed cell death (PCD) resistance is a key driver of cancer occurrence and development. The prognostic relevance of PCD-related genes in...
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Cross-tissue patterns of DNA hypomethylation reveal genetically distinct histories of cell development
BackgroundEstablishment of DNA methylation (DNAme) patterns is essential for balanced multi-lineage cellular differentiation, but exactly how these...
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Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis
Apart from being potential prognostic biomarkers and therapeutic targets, long non-coding RNAs (lncRNAs) modulate the development and progression of...
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SMCHD1 and LRIF1 converge at the FSHD-associated D4Z4 repeat and LRIF1 promoter yet display different modes of action
Facioscapulohumeral muscular dystrophy (FSHD) is caused by the epigenetic derepression of the 4q-linked D4Z4 macrosatellite repeat resulting in...
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Novel blood-based hypomethylation of SH3BP5 is associated with very early-stage lung adenocarcinoma
BackgroundEarly detection is essential to improve the survival of lung cancer (LC). The quantitative measurement of specific DNA methylation changes...
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Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer
BackgroundPreviously, we reported lower RSK4 mRNA and protein levels in malignant ovarian tumors compared to normal and benign ovarian tissues. Also,...
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Differentially methylation of IFI44L gene promoter in Iranian patients with systemic lupus erythematosus and rheumatoid arthritis
BackgroundSystemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are multisystemic autoimmune diseases with multifactorial nature....
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Temporal Control of Promoter Activity During the Caulobacter Cell Cycle
A cascade of cellular events must occur to allow cells to complete one round of cell division. Such a successful cell division cycle relies on the...
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The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer
Three-dimensional (3D) epigenome remodeling is an important mechanism of gene deregulation in cancer. However, its potential as a target to...
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Impaired Fanconi anemia pathway causes DNA hypomethylation in human angiosarcomas
Angiosarcomas (AS) is a rare soft tissue sarcomas with poor treatment options and a dismal prognosis. The abnormal DNA methylation pattern has been...
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Association of lipid metabolism-related gene promoter methylation with risk of coronary artery disease
Background:Coronary artery disease (CAD) is a complex disease that is influenced by environmental and genetic factors. Lipid levels are regarded as a...
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Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth
BackgroundPreterm birth, defined as parturition before 37 completed weeks of gestation, is associated with an increased risk of neonatal...
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Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers
BackgroundDNA hypermethylation is an epigenetic feature that modulates gene expression, and its deregulation is observed in cancer. Previously, we...
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Hypomethylation of LIMD1 and P16 by downregulation of DNMT1 results in restriction of liver carcinogenesis by amarogentin treatment
Amarogentin (active component of Chirata ) was found to prevent CCl4/NDEA-induced liver carcinogenesis at mild dysplastic stage through modulation of...
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DNA methylation patterns suggest the involvement of DNMT3B and TET1 in osteosarcoma development
DNA methylation may be involved in the development of osteosarcomas. Osteosarcomas commonly arise during the bone growth and remodeling in puberty,...
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Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer progression
Transcription factor (TF) proteins regulate gene activity by binding to regulatory regions, most importantly at gene promoters. Many genes have...
