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Unveiling the therapeutic potential of thymol from Nigella sativa L. seed: selective anticancer action against human breast cancer cells (MCF-7) through down-regulation of Cyclin D1 and proliferative cell nuclear antigen (PCNA) expressions
BackgroundBreast adenocarcinoma cells (MCF-7) are characterized by the overexpression of apoptotic marker genes and proliferative cell nuclear...
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Effects of Interferon-γ and Interleukin-4 on Proliferating Cell Nuclear Antigen Expression in Transplanted Bone Tumor Tissue
The rabbit VX2 bone tumor model is an ideal animal model for studying malignant bone tumors. Cytokines have been reported to play a role in tumor...
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The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader
Humans have three different proliferating cell nuclear antigen (PCNA) clamp-loading complexes: RFC and CTF18-RFC load PCNA onto DNA, but ATAD5-RFC...
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Detection of markers for proliferation, stem cell, and EMT in the gills of Pacific abalone Haliotis discus hannai
The hemocytes of molluscs take various roles including immunity and wound healing. Oyster gill was found to undergo hematopoiesis and produce adult...
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PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion
Sister chromatid cohesion, established during replication by the ring-shaped multiprotein complex cohesin, is essential for faithful chromosome...
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KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA
AimsTo explore the function of phosphorylation of KAP1 (p-KAP1) at the serine-824 site (S824) in the proliferation and apoptosis of endogenous neural...
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Application of EdU-Based DNA Synthesis Assay to Measure Hepatocyte Proliferation In Situ During Liver Regeneration
Monitoring hepatocyte proliferation in situ following partial hepatectomy is widely used to characterize cytokines, growth factors and signaling...
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DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp
The 9-1-1 DNA checkpoint clamp is loaded onto 5′-recessed DNA to activate the DNA damage checkpoint that arrests the cell cycle. The 9-1-1 clamp is a...
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The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
Changes in the location of γ-tubulin ensure cell survival and preserve genome integrity. We investigated whether the nuclear accumulation of...
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Loss of FAM172A gene prompts cell proliferation in liver regeneration
The present study was designed to explore the function of FAM172A in liver regeneration and HCC. Mice were sacrificed after 70% partial hepatectomy...
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Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies
Colorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor...
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Investigating Heterogeneous Cell-Cycle Progression Using Single-Cell Imaging Approaches
Investigating cell-cycle progression has been challenging due to the complex interconnectivity of regulatory processes and inherent cell-to-cell...
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Section Immunostaining for Protein Expression and Cell Proliferation Studies of Regenerating Fins
Adult zebrafishZebrafish finsFins fully regenerate after resection, providing a highly accessible and remarkable vertebrate model of organ...
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Monitoring Cellular Proliferation and Apoptosis in Atherosclerosis Plaques and Intimal Thickenings
Immunohistochemistry for specific proteins characteristic of proliferative or apoptotic cells allows for monitoring of these cell behaviors in...
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Effects of salinity on gill histology in sailfin velifera (Poecilia velifera)
Fish live in aquatic areas with varying salinity from fresh water to seawater. Gills are one of the most important osmoregulatory organs for...
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Selection of optimal quantile protein biomarkers based on cell-level immunohistochemistry data
BackgroundProtein biomarkers of cancer progression and response to therapy are increasingly important for improving personalized medicine. Advanced...
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Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression
This study was designed to investigate the role of a disintegrin and metalloproteinase domain-like protein decysin 1 (ADAMDEC-1) in atherosclerosis...
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Analyses of POL30 (PCNA) reveal positional effects in transient repression or bi-modal active/silent state at the sub-telomeres of S. cerevisiae
BackgroundClassical studies on position effect variegation in Drosophila have demonstrated the existence of bi-modal Active/Silent state of the...
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Cloning and comparative studies of proliferating cell nuclear antigen (PCNA) genes for nine dinoflagellates
Proliferating cell nuclear antigen (PCNA), a co-factor of DNA polymerases δ and ε, is associated with active cell proliferation, particularly with...
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The DDUP protein encoded by the DNA damage-induced CTBP1-DT lncRNA confers cisplatin resistance in ovarian cancer
Sustained activation of DNA damage response (DDR) signaling has been demonstrated to play vital role in chemotherapy failure in cancer. However, the...
