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A type III polyketide synthase cluster in the phylum Planctomycetota is involved in alkylresorcinol biosynthesis
AbstractMembers of the bacterial phylum Planctomycetota have recently emerged as promising and for the most part untapped sources of novel bioactive...
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Biosynthesis of macrolactam antibiotics with β-amino acid polyketide starter units
Macrolactam antibiotics incorporating β-amino acid polyketide starter units, isolated primarily from Actinomycetes species, show significant...
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SfuPKS2, a novel type III polyketide synthase from Sargassum fusiforme, shows high substrate specificity
A type III polyketide synthase (SfuPKS2) from the edible seaweed Sargassum fusiforme was cloned and biochemically characterized. SfuPKS2 can only...
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Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13
The mycolic acid layer of the Mycobacterium tuberculosis cell wall is essential for viability and virulence, and the enzymes responsible for its...
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Identification of polyketide synthase genes required for aspinolide biosynthesis in Trichoderma arundinaceum
AbstractThe fungus Trichoderma arundinaceum exhibits biological control activity against crop diseases caused by other fungi. Two mechanisms that...
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Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway
Presently, the supply of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) traditionally produced by marine fisheries will be insufficient...
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Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition
Corynebacterium glutamicum is a promising host for production of valuable polyketides. Propionate addition, a strategy known to increase polyketide...
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Screening of Polyketide Synthase Genes in the Anatoxin-a-Producing Cyanobacteria
Cyanobacterial blooms are a common occurrence in both freshwater and brackish environments. The cyanobacterial species in these habitats frequently...
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Overexpression of sesame polyketide synthase A leads to abnormal pollen development in Arabidopsis
BackgroundSesame is a great reservoir of bioactive constituents and unique antioxidant components. It is widely used for its nutritional and...
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Basidiomycete non-reducing polyketide synthases function independently of SAT domains
BackgroundNon-reducing polyketide synthases (NR-PKSs) account for a major share of natural product diversity produced by both Asco- and...
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Molecular Biology of Non-ribosomal Peptide (NRP) and Polyketide (PK) Biosynthesis in Cyanobacteria
Secondary metabolites produced by cyanobacteria are numerous and structurally diverse, with a focus on non-ribosomal peptide and polyketide...
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Structural and mechanistic insights into Quinolone Synthase to address its functional promiscuity
Quinolone synthase from Aegle marmelos (AmQNS) is a type III polyketide synthase that yields therapeutically effective quinolone and acridone...
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Identification of novel inhibitors for mycobacterial polyketide synthase 13 via in silico drug screening assisted by the parallel compound screening with genetic algorithm-based programs
Identifying small compounds capable of inhibiting Mycobacterium tuberculosis polyketide synthase 13 (Pks13), in charge of final step of mycolic acid...
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Overexpression of plant polyketide synthase AsPECPS from Aquilaria sinensis enhances the tolerance of the transgenic Nicotiana benthamiana to salt stress and ABA treatment
Type III polyketide synthases play significant roles in the biosynthesis of multiple plant secondary metabolites and plant adjustment to...
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Ice nucleation in a Gram-positive bacterium isolated from precipitation depends on a polyketide synthase and non-ribosomal peptide synthetase
Earth’s radiation budget and frequency and intensity of precipitation are influenced by aerosols with ice nucleation activity (INA), i.e., particles...
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Molecular characterization and differential expression of an aromatic heptaketide producing type III plant polyketide synthase from Himalayan rhubarb
Rheum australe (Himalayan Rhubarb, Polygonaceae), an endangered medicinal and vegetable herb owes its age-old remedying properties to the bio-active...
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In silico prediction of polyketide biosynthetic gene clusters in the genomes of Hypericum-borne endophytic fungi
BackgroundThe search for new bioactive natural compounds with anticancer activity is still of great importance. Even though their potential for...
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Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis
BackgroundType I polyketide synthases (PKSs) are multifunctional enzymes responsible for the biosynthesis of a group of diverse natural compounds...
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Heterologous Expression, Purification, and Characterization of Type II Polyketide Synthase Acyl Carrier Proteins
The enzymes that comprise type II polyketideType II polyketides synthases Polyketide synthases (PKSs) are powerful biocatalysts that, once...
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A polyketide synthase from Verticillium dahliae modulates melanin biosynthesis and hyphal growth to promote virulence
BackgroundDuring the disease cycle, plant pathogenic fungi exhibit a morphological transition between hyphal growth (the phase of active infection)...
