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The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores
The process of identifying suitable genome-wide association (GWA) studies and formatting the data to calculate multiple polygenic risk scores on a...
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Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction
Polygenic risk score (PRS) is useful for capturing an individual’s genetic susceptibility. However, previous studies have not fully exploited the...
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The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank
Large-scale genome-wide association studies (GWAS) strongly suggest that most traits and diseases have a polygenic component. This observation has...
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Rank concordance of polygenic indices
Polygenic indices (PGIs) are increasingly used to identify individuals at risk of develo** disease and are advocated as screening tools for...
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Integration of polygenic and gut metagenomic risk prediction for common diseases
Multiomics has shown promise in noninvasive risk profiling and early detection of various common diseases. In the present study, in a prospective...
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The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits
To investigate assortative mating (AM), participation bias and socioeconomic status (SES) with respect to the genetics of behavioural and psychiatric...
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Overestimated prediction using polygenic prediction derived from summary statistics
BackgroundWhen polygenic risk score (PRS) is derived from summary statistics, independence between discovery and test sets cannot be monitored. We...
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Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction
BackgroundGenetic variants can contribute differently to trait heritability by their functional categories, and recent studies have shown that...
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Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
BackgroundPolygenic risk scores (PRS) are valuable to translate the results of genome-wide association studies (GWAS) into clinical practice. To...
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Analysis of polygenic selection in purebred and crossbred pig genomes using generation proxy selection map**
BackgroundArtificial selection on quantitative traits using breeding values and selection indices in commercial livestock breeding populations causes...
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Feasibility and application of polygenic score analysis to the morphology of human-induced pluripotent stem cells
Genome-wide association studies have identified thousands of significant associations between genetic variants and complex traits. Inferring...
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Capturing additional genetic risk from family history for improved polygenic risk prediction
Family history of complex traits may reflect transmitted rare pathogenic variants, intra-familial shared exposures to environmental and lifestyle...
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Integrating polygenic and clinical risks to improve stroke risk stratification in prospective Chinese cohorts
The utility of the polygenic risk score (PRS) to identify individuals at higher risk of stroke beyond clinical risk remains unclear, and we clarified...
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From Genotype to Phenotype: Polygenic Prediction of Complex Human Traits
Decoding the genome confers the capability to predict characteristics of the organism (phenotype) from DNA (genotype). We describe the present status...
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Joint impact of polygenic risk score and lifestyles on early- and late-onset cardiovascular diseases
Understanding the interactions between genetic risk and lifestyles on different types and age onsets of cardiovascular disease (CVD) risk can help...
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Can polygenic risk scores help explain disease prevalence differences around the world? A worldwide investigation
Complex disorders are caused by a combination of genetic, environmental and lifestyle factors, and their prevalence can vary greatly across different...
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High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile
Healthy metabolic measures in humans are associated with longevity. Dysregulation leads to metabolic syndrome (MetS) and negative health outcomes....
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Association between polygenic propensity for psychiatric disorders and nutrient intake
Despite the observed associations between psychiatric disorders and nutrient intake, genetic studies are limited. We examined whether polygenic...
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Polygenic risk score model for renal cell carcinoma in the Korean population and relationship with lifestyle-associated factors
BackgroundThe polygenic risk score (PRS) is used to predict the risk of develo** common complex diseases or cancers using genetic markers. Although...
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Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease
Abstract BackgroundWith a growing number of loci associated with late-onset (sporadic) Alzheimer’s disease (AD), the polygenic contribution to AD is...
