Search
Search Results
-
Kidney Disease and Proteomics: A Recent Overview of a Useful Tool for Improving Early Diagnosis
Kidney disease is a critical and potentially life-threatening degenerative condition that poses a significant global public health challenge due to...
-
Chronic Kidney Disease: Challenges in Translational Medicine
Chronic kidney disease (CKD) has long been recognized as a state of progressive decline in renal function. Morbidity and mortality are well...
-
Evaluation of a proteomic signature coupled with the kidney failure risk equation in predicting end stage kidney disease in a chronic kidney disease cohort
BackgroundThe early identification of patients at high-risk for end-stage renal disease (ESRD) is essential for providing optimal care and...
-
Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between...
-
The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease
Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and is characterized by progressive growth of...
-
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
BackgroundKidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease modeling, and cell...
-
Genetic variants affecting mitochondrial function provide further insights for kidney disease
BackgroundChronic kidney disease (CKD) is a complex disorder that has become a high prevalence global health problem, with diabetes being its...
-
Role of ferroptosis in chronic kidney disease
Chronic kidney disease (CKD) has historically been a significant global health concern, profoundly impacting both life and well-being. In the process...
-
The impact of hypoxia preconditioning on mesenchymal stem cells performance in hypertensive kidney disease
BackgroundAutologous mesenchymal stem cells (MSCs) have emerged as a therapeutic option for many diseases. Hypertensive kidney disease (HKD) might...
-
Proteomic signature associated with chronic kidney disease (CKD) progression identified by data-independent acquisition mass spectrometry
BackgroundHalting progression of chronic kidney disease (CKD) to established end stage kidney disease is a major goal of global health research. The...
-
Adenine base editor corrected ADPKD point mutations in hiPSCs and kidney organoids
Autosomal dominant polycystic kidney disease (ADPKD) is a dominant genetic disorder caused primarily by mutations in the PKD1 gene, resulting in the...
-
Association of TCF7L2 Gene Variant (rs12255372) with Polycystic Ovary Syndrome and its Effect Modification of the Disease Phenotype
Polycystic ovary syndrome (PCOS) and type-2 diabetes mellitus (T2DM) share common genetic features. Transcription factor 7-like-2 (TCF7L2 ) is...
-
Hyaluronan in Kidney Fibrosis
The kidney is the organ responsible for the regulation of the body’s fluid balance. Hyaluronan (HA), because of its unique hydration capacity, is...
-
Tubular TMEM16A promotes tubulointerstitial fibrosis by suppressing PGC-1α-mediated mitochondrial homeostasis in diabetic kidney disease
Tubulointerstitial fibrosis (TIF) plays a crucial role in the progression of diabetic kidney disease (DKD). However, the underlying molecular...
-
Assessment of the Phytochemical Constituents and Metabolites in Medicinal Plants and Herbal Remedies Used in the Treatment and Management of Reproductive Diseases: Polycystic Ovary Syndrome
The present study explores the phytochemical constituents and metabolites found in medicinal plants and herbal remedies traditionally used for...
-
Assessment of the Phytochemical Constituents and Metabolites in Medicinal Plants and Herbal Remedies Used in the Treatment and Management of Reproductive Diseases: Polycystic Ovary Syndrome
The present study explores the phytochemical constituents and metabolites found in medicinal plants and herbal remedies traditionally used for...
-
Serum Magnesium Levels in Patients with Chronic Kidney Disease: Is There a Relationship with Inflammation Status?
Background: Magnesium (Mg 2+ ) is a fundamental mineral that maintains cellular function, and low levels may be linked to inflammation in patients with...
-
Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis
BackgroundChronic kidney disease (CKD) accelerates atherosclerosis, but the mechanisms remain unclear. Tyrosine sulfation has been recognized as a...
-
Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
Kidney diseases remain one of the leading causes of human death and have placed a heavy burden on the medical system. Regulated cell death...
