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The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance
Coagulation factor replacement therapy for the X-linked bleeding disorder Haemophilia, characterized by a deficiency of coagulation protein factor...
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Microtiter plate assays to assess antibiofilm activity against bacteria
Bacterial biofilms demonstrate high broad-spectrum adaptive antibiotic resistance and cause two thirds of all infections, but there is a lack of...
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In Vitro Biological Evaluation of Some Synthesized Novel 5-Substituted-2-(substituted)hydazineyl-1,3-thiazolidin-4-ones
AbstractThe 2-[2-(1-(4-chlorophenyl)ethylidene]hydrazineyl-1,3-thiazolidin-4-one ( V ) compound was synthesized via the condensation of...
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A plate-based single-cell ATAC-seq workflow for fast and robust profiling of chromatin accessibility
Profiling chromatin accessibility at the single-cell level provides critical information about cell type composition and cell-to-cell variation...
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Synthesis and Biological Activities of Some 3,5-Disubstituted-6-Oxo-1,2,4-Triazine-2-Thiocarboxamide Derivatives as Anti-Breast Cancer (MCF) and α-Glucosidase Inhibitors
AbstractA new series of trisubstituted-1,2,4-triazin-6-one derivatives ( III – VIII ) containing cinnmylidene and disubstituted phenyl (bearing acetoxy...
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Skeleton and Musculature of the Male Genitalia in Psilidae (Diptera) and Their Implications for the Phylogeny
AbstractWe have previously studied the musculature of the male genitalia in one species of Psilidae— Chyliza vittata Meigen, 1826. Here, we describe...
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Imidazole-Thiazolidine-2,4-dione Conjugated 1,2,3-Triazole Derivatives as Tubulin Aiming Antiproliferative Agents
AbstractA new series of imidazole-thiazolidine-2,4-dione coupled 1,2,3-triazoles ( VIIa–VIIm ) were synthesized using Knoevengal condensation and...
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Prevalence of Type III Secretion System (T3SS) and Biofilm Development in Genetically Heterogeneous Clinical Isolates of Pseudomonas aeruginosa from Nigeria
Pseudomonas aeruginosa infection in seriously ill patients is a major concern due to its ability to form biofilm and secrete effector toxins. There...
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Structural Features of Female Genitalia in Some Species of Histerid Beetles (Coleoptera, Histeridae)
AbstractThe ovipositor morphology in 12 species of Histeridae is considered, including the previously undescribed structures of the gonocoxites,...
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FTIR-ATR chemometric analysis on pelagic Sargassum reveals chemical composition changes induced by cold sample transportation and sunlight radiation
The massive arrival of Sargassum biomass on the Caribbean coast is a potential raw material source that needs an assessment of its quality and...
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Long-Term Adaptation to Galactose as a Sole Carbon Source Selects for Mutations Outside the Canonical GAL Pathway
Galactose is a secondary fermentable sugar that requires specific regulatory and structural genes for its assimilation, which are under catabolite...
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Schiff Base of Isatin with 2-Thiopheneethylamine and Its Mannich Bases: Synthesis, Docking, and In Vitro Anti-Inflammatory and Antitubercular Activity
AbstractA series of Schiff base conjugate of isatin with 2-thiopheneethylamine and its Mannich bases 3‑(2-(thiophen-2-yl) ethylimino)indolin-2-ones (
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Type status and taxonomic accounts for Ambiserrula jugosa (McCulloch 1914) and Inegocia harrisii (McCulloch 1914) (Scorpaeniformes: Platycephalidae)
Platycephalids Ambiserrula jugosa (McCulloch 1914) and Inegocia harrisii (McCulloch 1914) were described as new species based on 10 and 2 specimens,...
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Norfloxacin Analogues: Drug Likeness, Synthesis, Biological, and Molecular Docking Assessment
AbstractNorfloxacin ( I ) and its 1,3,4-oxadiazole, thiazolidin-4-one, 1,3,4-oxadiazoline, 1,2,4-triazole, Schiff’s base, hydrazide and...
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A New Species of the Sawfly Genus Spinarge Wei, 1998 (Hymenoptera, Argidae) from the Dzhungarian Ala Tau Mountains, Kazakhstan
AbstractA new sawfly species is described from the Dzungarian Alatau Mountains: Spinarge dzhungariensis sp. n. The new species has a brownish black...
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Benzofuran Hybrids as Cholinesterase (AChE and BChE) Inhibitors: In Vitro, In Silico, and Kinetic Studies
AbstractCholinesterase enzymes (AChE and BChE) play a vital function in cholinergic deficit that precedes to Alzheimer’s disease (AD). The inhibition...
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Bioprospecting of multi-stress tolerant Pseudomonas sp. antagonistic to Rhizoctonia solani for enhanced wheat growth promotion
Salt affected cotton rhizospheric soil was explored for multi-stress resistance microbes to obtain 46 rhizobacteria. Of these, seven strains strongly...
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Identification of myosin genes and their expression in response to biotic (PVY, PVX, PVS, and PVA) and abiotic (Drought, Heat, Cold, and High-light) stress conditions in potato
BackgroundPlant organelles are highly motile where their movement is significant for fast distribution of material around the cell, facilitation of...
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The first mitogenomic phylogenetic framework of Dorcus sensu lato (Coleoptera: Lucanidae), with an emphasis on generic taxonomy in Eastern Asia
BackgroundDorcus stag beetles in broad sense are one of the most diverse group in Lucanidae and important saproxylic insects playing a crucial role...
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Tribe Gymnusini Heer, 1839
A diagnosis of the tribe Gymnusini Heer is presented, with a review of species of Gymnusa Gravenhorst and Deinopsis Matthews. The following is...