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Exploring characteristics of placental transcriptome and cord serum metabolome associated with low birth weight in Kele pigs
The neonate with low birth weight (LBW) resulted from intrauterine growth retardation (IUGR) exists a substantial risk of postpartum death. Placental...
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Impact of Fluoride Exposure on Rat Placenta: Foetal/Placental Morphometric Alterations and Decreased Placental Vascular Density
Inorganic fluoride is a geogenic and anthropogenic contaminant widely distributed in the environment and commonly identified in contaminated...
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Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations
Obesity and gestational diabetes (GDM) impact fetal growth during pregnancy. Iron is an essential micronutrient needed for energy-intense...
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A review of the amino acid metabolism in placental function response to fetal loss and low birth weight in pigs
The fertility of sows mainly depends on the embryo losses during gestation and the survival rate of the post-farrowing piglets. The selection of...
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Associations of the placental metabolome with immune maturation up to one year of age in the Swedish NICE-cohort
IntroductionAllergies and other immune-mediated diseases are thought to result from incomplete maturation of the immune system early in life. We...
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Deciphering the Epigenetic Landscape: Placental Development and Its Role in Pregnancy Outcomes
The placenta stands out as a unique, transitory, and multifaceted organ, essential to the optimal growth and maturation of the fetus. Functioning as...
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Konjac flour-mediated gut microbiota alleviates insulin resistance and improves placental angiogenesis of obese sows
Our previous study revealed that dietary konjac flour (KF) could remodel gut microbiota and improve reproductive performance of sows, but its...
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Connective tissue matrices from placental disc for wound healing: mini-review
AbstractWound management is a complex procedure that includes multiple factors that play major roles in the healing process. Extracellular...
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Therapeutic potential of miRNAs in placental extracellular vesicles in ovarian and endometrial cancer
There is a cross-link between the placenta and cancer development, as the placenta is grown as a highly invasive tumour-like organ. However,...
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Assessment of Placental Sodium-Independent Leucine Uptake and Transfer in Trophoblast Cells
The placenta maintains the balance between nutrition and growth control of the fetus through selective and regulated supply of macronutrients such as...
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Mechanisms underlying the role of endoplasmic reticulum stress in the placental injury and fetal growth restriction in an ovine gestation model
BackgroundExposure to bisphenol A (BPA), an environmental pollutant known for its endocrine-disrupting properties, during gestation has been reported...
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Maternal exposure to polystyrene microplastics alters placental metabolism in mice
IntroductionThe rapid growth in the worldwide use of plastics has resulted in a vast accumulation of microplastics in the air, soil and water. The...
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Ensemble learning for predicting ex vivo human placental barrier permeability
BackgroundThe placental barrier protects the fetus from exposure to some toxicants and is vital for drug development and risk assessment of...
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Placental Streptococcus agalactiae DNA is associated with neonatal unit admission and foetal pro-inflammatory cytokines in term infants
Streptococcus agalactiae (Group B Streptococcus ; GBS) is a common cause of sepsis in neonates. Previous work detected GBS DNA in the placenta in ~5%...
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Downregulation of argininosuccinate synthase 1 (ASS1) is associated with hypoxia in placental development
Argininosuccinate synthase (ASS1) is involved in nitric oxide production, which has a key role in placental development improving pregnancy outcomes....
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Aspirin-Mediated Reset of Preeclamptic Placental Stem Cell Transcriptome – Implication for Stabilized Placental Function
Preeclampsia (PE) is a pregnancy-specific disease, occurring in ~ 2–10% of all pregnancies. PE is associated with increased maternal and perinatal...
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Placental oxidative stress and monoamine oxidase expression are increased in severe preeclampsia: a pilot study
Preeclampsia (PE) is the most severe complication of pregnancy with substantial burden of morbidity and mortality for mother and neonate. The...
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Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature
The placenta is a unique organ for ensuring normal embryonic growth in the uterine. Here, we found that maternal RNA transcription in Dlk1-Dio3 ...
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Three-Dimensional In Vitro Human Placental Organoids from Mononuclear Villous Trophoblasts or Trophoblast Stem Cells to Understand Trophoblast Dysfunction in Fetal Growth Restriction
The placentaPlacenta plays a critical role in the efficient delivery of nutrients and oxygen from mother to fetus to maintain normal fetal growth....
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Placental metabolite profiles in late gestation for healthy mice
IntroductionDuring pregnancy, appropriate placental metabolism is essential for fetuses to reach their growth potential. However, metabolic...
