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Placenta-targeted Treatment Strategies for Preeclampsia and Fetal Growth Restriction: An Opportunity and Major Challenge
The placenta plays a crucial role in maintaining normal pregnancy. The failure of spiral artery remodeling (SAR) is a key factor leading to placental...
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A proteomic profile of the healthy human placenta
BackgroundThe placenta remains one of the least studied organs within the human body. Yet, placental dysfunction has been associated with various...
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A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia
Preeclampsia is a pregnancy-specific cardiovascular disorder, involving significant maternal endothelial dysfunction. Although inappropriate...
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Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells
BackgroundFoetal renal dysplasia is still the main cause of adult renal disease. Placenta-derived exosomes are an important communication tool, and...
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Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns
BackgroundHealth outcomes among children born prematurely are known to be sexually dimorphic, with male infants often more affected, yet the...
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Morfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus
AbstractGestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is...
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Prenatal aripiprazole induces alterations of rat placenta: a histological, immunohistochemical and ultrastructural study
Antipsychotic drugs (APDs) are used to treat many psychiatric illnesses as schizophrenia. Typical antipsychotic drugs (TAPDs) are being used;...
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Imbalance of Angiogenic and Growth Factors in Placenta in Maternal Hyperhomocysteinemia
AbstractNumerous studies have shown that various adverse factors of different nature and action mechanisms have similar negative influence on...
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A Bioengineered Model for Studying Vascular-Pericyte Interactions of the Placenta
Investigating the complex cellular interactions of the placenta has remained, until now, a challenge in the field. Given the ethical limitations of...
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Epigenetic Mechanisms Involved in the Effects of Maternal Hyperhomocysteinemia on the Functional State of Placenta and Nervous System Plasticity in the Offspring
AbstractAccording to modern view, susceptibility to diseases, specifically to cognitive and neuropsychiatric disorders, can form during embryonic...
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Gene expression of iron transporters, markers of vascularization and structural integrity in placenta of mothers with and without anemia
ObjectiveTo compare the mRNA expression of placental iron transporters (TfR-1 and FPN), markers of placental vascularization (VEGF and sFLT1) and...
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Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta
BackgroundThe maternal microbiota modulates fetal development, but the mechanisms of these earliest host-microbe interactions are unclear. To...
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Mucin1 induced trophoblast dysfunction in gestational diabetes mellitus via Wnt/β-catenin pathway
BackgroundTo elucidate the role of Mucin1 (MUC1) in the trophoblast function (glucose uptake and apoptosis) of gestational diabetes mellitus (GDM)...
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Gene expression profile of placentomes and clinical parameters in the cows with retained placenta
BackgroundRetained placenta (RP) is a prevalent disorder in cattle with many health-related and economic costs for the farm owners. Its etiology has...
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YAP-mediated trophoblast dysfunction: the common pathway underlying pregnancy complications
Yes-associated protein (YAP) is a pivotal regulator in cellular proliferation, survival, differentiation, and migration, with significant roles in...
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NINJ1 triggers extravillous trophoblast cell dysfunction through blocking the STAT3 signaling pathway
BackgroundTrophoblasts are the most important parts of the placenta in early pregnancy. Trophoblast cell dysfunction can induce embryo implantation...
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Human umbilical cord/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro
BackgroundA significant unmet need in inflammatory bowel disease is the lack of anti-fibrotic agents targeting intestinal fibrosis. This study aimed...
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PFKFB3-mediated glycometabolism reprogramming modulates endothelial differentiation and angiogenic capacity of placenta-derived mesenchymal stem cells
BackgroundMesenchymal stem cells (MSCs) have a great potential ability for endothelial differentiation, contributing to an effective means of...
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Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection
Myeloid-derived suppressor cells (MDSCs) play a crucial role in maintaining maternal-fetal tolerance by expressing some immune-suppressive molecules,...
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Liposome-Encapsulated Anti-inflammatory Proteins for Targeted Delivery to the Placenta to Treat Fetal Growth Restriction
Fetal growth restriction (FGR), the failure of a fetus to reach its genetically determined growth potential, is a serious complication affecting up...