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Developmental expression of CREB1 and NFATC2 in pig embryos
BackgroundThe CREB1 gene encodes the cAMP response element binding protein 1 (CREB1), a leucine zipper transcription factor that regulates cellular...
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Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
BackgroundAcute kidney injury (AKI) is a common clinical disorder with complex etiology and poor prognosis, and currently lacks specific and...
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Genome-wide annotation of protein-coding genes in pig
BackgroundThere is a need for functional genome-wide annotation of the protein-coding genes to get a deeper understanding of mammalian biology. Here,...
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Microtubule-associated protein tau in murine kidney: role in podocyte architecture
Tau is a cytoskeletal protein that is expressed mainly in neurons and is involved in several cellular processes, such as microtubule stabilization,...
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Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model
BackgroundRemote Ischemic Conditioning (RIC) has been proposed as a therapeutic intervention to circumvent the ischemia/reperfusion injury (IRI) that...
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Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity
DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age, epigenetic clocks, for many species. Using a...
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Non-α1,3Gal Carbohydrate Antigenic Epitopes
Non-Gal (Non-α1,3-Gal) antigenic epitope is also targeted by the cellular immune system. Preformed natural non-Gal Abs do not cause HR in...
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Solid Xenoorgan Xenotransplantation
Besides the immunological damages, the xenotransplantation also induces several blood and vascular damages through fatal hemorrhagic coagulation,...
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Reduced phosphorus intake throughout gestation and lactation of sows is mitigated by transcriptional adaptations in kidney and intestine
BackgroundThe environmental impact of pig farming need to be reduced, with phosphorus (P) being of particular interest. Specified dietary regimens...
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Investigation of congenital tremor associated with Classical swine fever virus genotype 2.2 in an organized pig farm in north-eastern India
The present study describes an outbreak of Classical swine fever (CSF) in an organized pig farm followed by an episode of CSF virus (CSFV) associated...
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Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs
BackgroundLong-term natural and artificial selection has resulted in many genetic footprints within the genomes of pig breeds across distinct...
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HIV, pathology and epigenetic age acceleration in different human tissues
Epigenetic clocks based on patterns of DNA methylation have great importance in understanding aging and disease; however, there are basic questions...
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Construction of a transposase accessible chromatin landscape reveals chromatin state of repeat elements and potential causal variant for complex traits in pigs
BackgroundA comprehensive landscape of chromatin states for multiple mammalian tissues is essential for elucidating the molecular mechanism...
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The study of antigen carrying and lesions observed in pigs that survived post African swine fever virus infection
African swine fever (ASF) is a dangerous infectious disease of domestic pigs and wild boar caused by African swine fever virus (ASFV). In Vietnam,...
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Severe cardiac and skeletal manifestations in DMD-edited microminipigs: an advanced surrogate for Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an intractable X-linked muscular dystrophy caused by mutations in the DMD gene. While many animal models have...
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Organic Selenium Alleviates Ammonia-Mediated Abnormal Autophagy by Regulating Inflammatory Pathways and the Keap1/Nrf2 Axis in the Hypothalamus of Finishing Pigs
Ammonia is a significant pollutant in the livestock houses and the atmospheric environment, and excessive ammonia would harm the health of livestock...
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The discovery, structure, and function of 5-HTR1E serotonin receptor
Serotonin (5-hydroxytryptamine, 5-HT) is a unique neurotransmitter which can regulate various biological processes by activating thirteen different...
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Identification and characterization of male reproduction-related genes in pig (Sus scrofa) using transcriptome analysis
BackgroundThe systematic interrogation of reproduction-related genes was key to gain a comprehensive understanding of the molecular mechanisms...
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Stem cell-derived kidney organoids: engineering the vasculature
Kidney organoids can be generated from human pluripotent stem cells (PSCs) using protocols that resemble the embryonic development of the kidney. The...
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Efficacy of Human Embryonic Stem Cells Compared to Adipose Tissue-Derived Human Mesenchymal Stem/Stromal Cells for Repair of Murine Post-Stenotic Kidneys
Clinical translation of mesenchymal stem/stromal cell (MSC) therapy has been impeded by the heterogenous nature and limited replicative potential of...
