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Photothrombotic Mouse Models for the Study of Melatonin as a Therapeutic Tool After Ischemic Stroke
Melatonin is a potent neuroprotective agent which has shown therapeutic effects in animal models of brain injury such as stroke. Currently, there are...
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Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk
Allicin exhibits various pharmacological activities and has been suggested to be beneficial in the treatment of stroke. However, the underlying...
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Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity
Microinfarcts are common among the elderly and patients with microinfarcts are more vulnerable to another stroke. However, the impact of...
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Deep learning-based behavioral profiling of rodent stroke recovery
BackgroundStroke research heavily relies on rodent behavior when assessing underlying disease mechanisms and treatment efficacy. Although functional...
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Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer
The receptor tyrosine kinase Mer (gene name Mertk ) acts in vascular endothelial cells (ECs) to tighten the blood-brain barrier (BBB) subsequent to...
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Therapeutic potential of stem cell extracellular vesicles for ischemic stroke in preclinical rodent models: a meta-analysis
BackgroundExtracellular vesicles derived from stem cells (SC-EVs) have been proposed as a novel therapy for ischemic stroke. However, their effects...
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Modeling transient ischemic attack via photothrombosis
The health significance of transient ischemic attacks (TIAs) is largely underestimated. Often, TIAs are not given significant importance, and in...
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Disruption of Calcium Homeostasis and Following Changes in Calcium Signaling in Neurons and Glial Cells in Response to Photodynamic Treatment
AbstractPhotodynamic impact on neurons and glial cells, causing oxidative stress and ischemic damage, is accompanied by disruption of calcium...
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The role of leukocytes in acute ischemic stroke-related thrombosis: a notable but neglected topic
Ischemic stroke is one of the most serious diseases today, and only a minority of patients are provided with effective clinical treatment....
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Precise control of embolic stroke with magnetized red blood cells in mice
Precise embolism control in immature brains can facilitate mechanistic studies of brain damage and repair after perinatal arterial ischemic stroke...
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Neuroprotective effect of heparin Trisulfated disaccharide on ischemic stroke
Cells undergoing hypoxia experience intense cytoplasmic calcium (Ca 2+ ) overload. High concentrations of intracellular calcium ([Ca 2+ ] i ) can trigger...
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Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury
Ischemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a...
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Hevin–calcyon interaction promotes synaptic reorganization after brain injury
Hevin, also known as SPARC-like protein 1 (SPARCL1 or SC1), is a synaptogenic protein secreted by astrocytes and modulates the formation of...
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Dual roles of hexokinase 2 in sha** microglial function by gating glycolytic flux and mitochondrial activity
Microglia continuously survey the brain parenchyma and actively shift status following stimulation. These processes demand a unique bioenergetic...
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Role of B cells and the aging brain in stroke recovery and treatment
As mitigation of brain aging continues to be a key public health priority, a wholistic and comprehensive consideration of the aging body has...
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Epigenetic Mechanisms of Ischemic Stroke
Abstract —Stroke is one of the main causes of human death and disability. Occlusion of the cerebral vessels in minutes leads to oxygen and glucose...
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Is blood-brain barrier a probable mediator of non-invasive brain stimulation effects on Alzheimer’s disease?
Alzheimer’s disease (AD) is a complex neurodegenerative disease with no existing treatment leading to full recovery. The blood-brain barrier (BBB)...
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The m6A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia
Persistent neuroinflammation and progressive neuronal loss are defining features of acute brain injury including traumatic brain injury (TBI) and...
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Vascular Functional Recovery and Reparation by Human Endothelial Progenitor Cells
Endogenous vascular reparation is based on mobilization, differentiation, and proliferation of bone marrow–derived and resident proangiogenic...
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Vascular Functional Recovery and Reparation by Human Endothelial Progenitor Cells
Endogenous vascular reparation is based on mobilization, differentiation, and proliferation of bone marrow–derived and resident proangiogenic...