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Development and multi-center clinical trials of an up-converting phosphor technology-based point-of-care (UPT-POCT) assay for rapid COVID-19 diagnosis and prediction of protective effects
BackgroundQuantitative point-of-care testing assay for detecting antibodies is critical to COVID-19 control. In this study, we established an...
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GSKIP modulates cell aggregation through EMT/MET signaling rather than differentiation in SH-SY5Y human neuroblastoma cells
GSK3β interacting protein (GSKIP) is a small A-kinase anchor protein previously reported to mediate the N-cadherin/β-catenin pool for differentiation...
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RETRACTED ARTICLE: Phosphor-IWS1-dependent U2AF2 splicing regulates trafficking of CAR-E-positive intronless gene mRNAs and sensitivity to viral infection
AKT-phosphorylated IWS1 promotes Histone H3K36 trimethylation and alternative RNA splicing of target genes, including the U2AF65...
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Development and evaluation of an up-converting phosphor technology-based lateral flow assay for rapid and quantitative detection of Coxiella burnetii phase I strains
BackgroundCoxiella burnetii is an obligate intracellular Gram-negative bacterium that causes a zoonotic disease commonly called Q fever globally. In...
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GLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma
BackgroundWhile previous studies have primarily focused on Glucose transporter type 1 (GLUT1) related glucose metabolism signaling, we aim to...
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Gemcitabine resistance of pancreatic cancer cells is mediated by IGF1R dependent upregulation of CD44 expression and isoform switching
Chemoresistance in pancreatic cancer cells may be caused by the expansion of inherently resistant cancer cells or by the adaptive plasticity of...
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Establishment and characterization of urothelial carcinoma cell lines with and without BRAF mutation (V595E) in dogs
Each 5 urothelial carcinoma (UC) cell lines with and without the v-Raf murine sarcoma virus oncogene homolog B (BRAF) gene mutation (V595E) were...
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Optimizing nutrient solution for vegetative growth of Dendrobium Tubtim Siam and Phalaenopsis Taisuco Swan through plant tissue nutrient balance estimation
BackgroundOrchids are grown without soil in many regions of the world, but there is a lack of studies to define the balanced and adequate nutrient...
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Der LEGO-Baukasten des Lebens
Es gibt erstaunlich viele Möglichkeiten, ein paar Atome der Elemente Kohlenstoff, Wasserstoff, Stickstoff und Sauerstoff miteinander zu kombinieren....
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Baicalin can enhance odonto/osteogenic differentiation of inflammatory dental pulp stem cells by inhibiting the NF-κB and β-catenin/Wnt signaling pathways
BackgroundScutellaria baicalensis Georgi is a famous traditional Chinese medicine, which is widely used in treating fever, upper respiratory tract...
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Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression
Androgen receptor (AR) signaling plays important roles in breast cancer progression. We show here that Kindlin-2, a focal adhesion protein, is...
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Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice
Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar...
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Distinctive phosphorylation pattern during mitotic exit network (MEN) regulation is important for the development and pathogenicity of Magnaporthe oryzae
The mitotic exit network (MEN) pathway is a vital kinase cascade regulating the timely and correct progress of cell division. In the rice blast...
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Exploring the chemotherapeutic potential and therapeutic insight of phloretin against human malignancies: a systematic review
T he search of alternative therapeutic agents for the use of cancer patients has dramatically expanded. Natural products are especially in focus...
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β-acetoxyisovaleryl alkannin (AAN-II) from Alkanna tinctoria promotes the healing of pressure-induced venous ulcers in a rabbit model through the activation of TGF-β/Smad3 signaling
Alkannin-based pharmaceutical formulations for improving wound healing have been on the market for several years. However, detailed molecular...
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Research and Optimization of the Synthesis of GdF3:Tb X-Ray Phosphors for X-Ray Photodynamic Therapy
AbstractObjective: GdF 3 :Tb nanosized phosphors were synthesized by the sol–gel and hydrothermal methods. Directed crystallite growth toward the...
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QTL map** of maize (Zea mays L.) kernel traits under low-phosphorus stress
Low-phosphorus stress significantly impacts the development of maize kernels. In this study, the phosphor efficient maize genotype 082 and phosphor...
