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Histidine Kinase PhoQ Is a Critical Regulator for Selenium Metabolism in Rahnella aquatilis HX2 and Enhances Selenium Bioavailability in Soil
PhoP/PhoQ, the two-component regulatory system, plays a significant role in regulating the functions of many Gram-negative bacteria. This study...
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Combined transcriptomic and metabolomic analysis of Salmonella in the presence or absence of PhoP–PhoQ system under low Mg2+ conditions
IntroductionPrevious reports revealed the role played by Salmonella PhoP–PhoQ system in virulence activation, antimicrobial tolerance and...
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Acid tolerance response of Salmonella during the squid storage and its amine production capacity analysis
Salmonella exhibits a strong inducible acid tolerance response (ATR) under weak acid conditions, and can also induce high-risk strains that are...
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Molecular characterization of colistin resistance genes in a high-risk ST101/KPC-2 clone of Klebsiella pneumoniae in a University Hospital of Split, Croatia
Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) has become a major concern worldwide due to multidrug resistance and the ability...
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Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring blaNDM-1 and blaKPC-2 in a tertiary hospital in China
BackgroundThe prevalence of multidrug-resistant hypervirulent K. pneumoniae (MDR-hvKP) has gradually increased. It poses a severe threat to human...
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Genoty** of paired KPC-producing Klebsiella pneumoniae isolates with and without divergent polymyxin B susceptibility profiles
Polymyxins are still used mainly in treating infections caused by carbapenem-resistant Klebsiella pneumoniae worldwide. The most frequent mechanism...
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Detection of colistin-resistant populations prior to antibiotic exposure in KPC-2-producing Klebsiella pneumoniae clinical isolates
Although colistin is frequently regarded as the antibiotic of last resort in treating carbapenem-resistant Klebsiella pneumoniae , colistin...
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Molecular and genome characterization of colistin-resistant Escherichia coli isolates from wild sea lions (Zalophus californianus)
Using molecular and whole-genome sequencing tools, we investigated colistin-resistant Escherichia coli isolates from wild sea lions. Two unrelated E....
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Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria
BackgroundThe heteroresistance of polymyxin B, a last-resort antibiotic used to treat many serious bacterial infections, may lead to antibiotic...
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Mutations in two component system (PhoPQ and PmrAB) in colistin resistant Klebsiella pneumoniae from North Indian tertiary care hospital
Colistin resistance in Gram negative bacteria is mainly attributed to chromosomal mutations in Two Component Systems(TCS) PhoPQ and PmrAB and...
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PhoPQ two-component regulatory system plays a global regulatory role in antibiotic susceptibility, physiology, stress adaptation, and virulence in Stenotrophomonas maltophilia
BackgroundStenotrophomonas maltophilia , an opportunistic pathogen, is ubiquitously present in various environments, signifying its high capability...
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Colistin resistance in Gram-negative bacteria analysed by five phenotypic assays and inference of the underlying genomic mechanisms
BackgroundColistin is used against multi-drug resistant pathogens, yet resistance emerges through dissemination of plasmid-mediated genes ( mcr ) or...
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Influence of PhoPQ and PmrAB two component system alternations on colistin resistance from non-mcr colistin resistant clinical E. Coli strains
BackgroundThe current understanding of acquired chromosomal colistin resistance mechanisms in Enterobacterales primarily involves the disruption of...
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The Hha–TomB toxin–antitoxin module in Salmonella enterica serovar Typhimurium limits its intracellular survival profile and regulates host immune response
The key to bacterial virulence relies on an exquisite balance of signals between microbe and hosts. Bacterial toxin–antitoxin (TA) system is known to...
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Prevalence and molecular characterization of colistin resistance in Pseudomonas aeruginosa isolates: insights from a study in Ardabil hospitals
BackgroundPseudomonas aeruginosa is a common cause of nosocomial infections. However, the emergence of multidrug-resistant strains has complicated...
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Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases
Waldiomycin is an inhibitor of histidine kinases (HKs). Although most HK inhibitors target the ATP-binding region, waldiomycin binds to the...
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Rapid evolution of colistin resistance in a bioreactor model of infection of Klebsiella pneumoniae
Colistin remains an important antibiotic for the therapeutic management of drug-resistant Klebsiella pneumoniae . Despite the numerous reports of...
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Genomic variations in polymyxin-resistant Pseudomonas aeruginosa clinical isolates and their effects on polymyxin resistance
Infection with P. aeruginosa , one of the most relevant opportunistic pathogens in hospital-acquired infections, can lead to high mortality due to its...
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Bacterial Cold Shock Proteins as a Tool in Adaption to Stress
AbstractBacteria have evolved a number of ways for a co** with stress and adapting to changing environmental conditions. A family of bacterial...
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Synergistic antibacterial and anti-biofilm activities of resveratrol and polymyxin B against multidrug-resistant Pseudomonas aeruginosa
Bacterial infection caused by multidrug-resistant Pseudomonas aeruginosa has become a challenge in clinical practice. Polymyxins are used as the last...
